Recombinant Human CCR5 protein, Flag & His-tagged

• Cat.No.: CCR5-681H
• Product Overview: Human CCR5, Flag,His Tag is expressed from human 293 cells (HEK293). It contains AA Asp 2 - Arg 223 & Glu 227 - Arg 319 (Accession # P51681-1(C58Y,G163N,A233D,K303E)).

Specification

• Description: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation.5 Publications (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.
• Source: HEK293
• Species: Human
• Tag: Flag & His
• Predicted N Terminal: Asp
• Form: Delivered as bulk protein in a 0.2 μm filtered solution of 50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5 with Glycerol as protectant.
• Molecular Mass: The protein has a calculated MW of 46.0 kDa. The protein migrates as 33-35 kDa and 40-45 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
• Protein length: Asp 2 - Arg 223 & Glu 227 - Arg 319
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >85% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  The product MUST be stored at -70°C or lower upon receipt;
  -70°C for 3 months under sterile conditions.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
• Shipping: This product is supplied as sterile liquid solution and shipped frozen with dry ice, please inquire the shipping cost.

Gene Information

• Gene Name: CCR5 C-C motif chemokine receptor 5 [ Homo sapiens (human) ]
• Official Symbol: CCR5
• Synonyms: CCR5; CMKBR5; CD195; CC-CKR-5; CHEMR13
• Gene ID: 1234
• mRNA Refseq: NM_000579.4
• Protein Refseq: NP_000570.1
• MIM: 601373
• UniProt ID: P51681