Recombinant Human CCR5 Protein
Cat.No. : | CCR5-0693H |
Product Overview : | Human CCR5 full-length ORF (XP_001125981.1) recombinant protein without tag. |
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Description : | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles; the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2015] |
Source : | Wheat Germ |
Species : | Human |
Form : | Liquid |
Molecular Mass : | 40.5 kDa |
AA Sequence : | MDYQVSSPIYDINYYTSEPCQKINV KQIAARLLPPLYSLVFIFGFVGNML VILILINCKRLKSMTDIYLLNLAIS DLFFLLTVPFWAHYAAAQWDFGNTM CQLLTGLYFIGFFSGIFFIILLTID RYLAVVHAVFALKARTVTFGVVTSV ITWVVAVFASLPGIIFTRSQKEGLH YTCSSHFPYSQYQFWKNFQTLKIVI LGLVLPLLVMVICYSGILKTLLRCR NEKKRHRAVRLIFTIMIVYFLFWAP YNIVLLLNTFQEFFGLNNCSSSNRL DQAMQVTETLGMTHCCINPIIYAFV GEKFRNYLLVFFQKHIAKRFCKCCS IFQQEAPERASSVYTRSTGEQEISV GL |
Applications : | Antibody Production Functional Study Compound Screening |
Usage : | Heating may cause protein aggregation. Please do not heat this product before electrophoresis. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 25 mM Tris-HCl of pH8.0 containing 2% glycerol. |
Tag : | Non |
Gene Name : | CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) [ Homo sapiens ] |
Official Symbol : | CCR5 |
Synonyms : | CCR5; chemokine (C-C motif) receptor 5 (gene/pseudogene); chemokine (C C motif) receptor 5, CMKBR5; C-C chemokine receptor type 5; CC CKR 5; CD195; CKR 5; CKR5; IDDM22; chemr13; HIV-1 fusion coreceptor; chemokine receptor CCR5; C-C motif chemokine receptor 5 A159A; CCR-5; CKR-5; CCCKR5; CMKBR5; CC-CKR-5; FLJ78003; |
Gene ID : | 1234 |
mRNA Refseq : | NM_000579 |
Protein Refseq : | NP_000570 |
MIM : | 601373 |
UniProt ID : | P51681 |
Products Types
◆ Recombinant Protein | ||
CCR5-535R | Recombinant Rhesus Macaque CCR5 Protein, His (Fc)-Avi-tagged | +Inquiry |
CCR5-192H | Recombinant Human CCR5 Protein, His-tagged | +Inquiry |
CCR5-644H | Recombinant Human CCR5 Protein, His-tagged | +Inquiry |
CCR5-887R | Recombinant Rat CCR5 Protein, His (Fc)-Avi-tagged | +Inquiry |
CCR5-1423M | Recombinant Mouse CCR5 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
CCR5-309HCL | Recombinant Human CCR5 cell lysate | +Inquiry |
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Customer Reviews (3)
Write a reviewWhen experiments are performed with CCR5, stable and reproducible results can be obtained.
CCR5 has a high yield and good economic benefits.
CCR5 exerts the expected biological effects in experiments.
Q&As (6)
Ask a questionIn the human body, CCR5 protein is mainly involved in the regulation of the immune system, it acts as a chemokine receptor, which can sense the signal of the site of inflammation and guide immune cells to reach the site of inflammation, thus playing a role in immune response.
There are still many unsolved questions and future research directions for CCR5 protein. For example, we need to better understand the structure-function relationship of CCR5, explore the interaction of CCR5 with other proteins and their potential implications, and develop more potent and selective CCR5 antagonists.
In immunotherapy, the function of CCR5 can be used for disease treatment, such as affecting the migration and activation of immune cells by regulating the expression or function of CCR5, so as to achieve the purpose of treating inflammatory diseases or autoimmune diseases. In addition, antibodies or antagonists against CCR5 may also be considered to inhibit its binding to ligands to further modulate the immune response.
CCR5 protein can interact with other receptors and signaling pathways. For example, in some cancer cells, CCR5 binds to EGFR (epidermal growth factor receptor), triggering EGFR activation and promoting tumor cell growth and metastasis. In addition, CCR5 is also involved in the regulation of signaling pathways such as MAPK (mitogen-activated protein kinase) and PI3K (phosphatidylinositol kinase).
Gene editing technology such as CRISPR-Cas9 can be used to modify or treat the CCR5 gene. By editing the CCR5 gene, the expression of CCR5 protein can be regulated or its function can be changed. This technique is expected to be used in the future to treat some genetic diseases or cancers associated with CCR5.
One way to use CCR5 protein for disease treatment is to use CCR5 antagonists, which are drugs that prevent CCR5 from binding to ligands. There are already a number of CCR5 antagonists in clinical trials for the treatment of diseases such as AIDS and rheumatoid arthritis.
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