CD248

Official Full Name

CD248 molecule, endosialin
Overview

Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal fibroblasts.
Synonyms

CD248; CD248 molecule, endosialin; TEM1; CD164L1; endosialin; 2610111G01Rik; CD164 sialomucin-like 1; CD248 antigen, endosialin; tumor endothelial marker 1;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Canine
Human
Mouse
Rhesus Macaque
Rhesus monkey

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

C
His
Fc
Flag
GST
hIgG4
His, Fc, Avi
SUMO
Strep

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CD248-23H	Active Recombinant Human CD248 Protein, His-tagged	Mammalian cells	His	Gln18-Arg685	Inquiry
Human	CD248-10932H	Recombinant Human CD248, GST-tagged	E.coli	GST	399-687a.a.	$319 / 25μg
Human	CD248-0758H	Recombinant Human CD248 Protein, GST-Tagged	Wheat Germ	GST	1-757aa	Inquiry
Human	CD248-315HCL	Recombinant Human CD248 cell lysate	HEK293	Flag	1-757aa	Inquiry
Human	CD248-3089HF	Recombinant Full Length Human CD248 Protein, GST-tagged	In Vitro Cell Free System	GST	757 amino acids	Inquiry
Human	CD248-230H	Recombinant Human CD248 protein, His-tagged	E.coli	His	21-401aa	Inquiry
Human	CD248-3581H	Recombinant Human CD248 Protein (Gly30-Cys156), C-His tagged	E.coli	His	Gly30-Cys156	Inquiry
Human	CD248-5033H	Recombinant Human CD248 protein, His-tagged	HEK293	C-His	Gln18-Leu687	Inquiry
Human	CD248-2630H	Recombinant Human CD248 Protein, His (Fc)-Avi-tagged	HEK293	His, Fc, Avi	18-695aa	Inquiry
Human	CD248-1111H	Recombinant Human CD248 Protein (Gln18-Glu245), N-His tagged	E.coli	His	Gln18-Glu245	Inquiry
Human	CD248-2630H-B	Recombinant Human CD248 Protein Pre-coupled Magnetic Beads	HEK293	His	18-695aa	Inquiry
Mouse	CD248-3063M	Recombinant Mouse CD248 Protein	Mammalian Cell	His	Full length or partial length	Inquiry
Mouse	Cd248-3533M	Recombinant Mouse Cd248 protein, His-tagged	HEK293	C-His	Gln18-Leu695	Inquiry
Mouse	Cd248-01M	Recombinant Mouse Cd248 Protein, His-tagged, Biotinylated	HEK293	His	18-695aa	Inquiry
Mouse	CD248-1447M	Recombinant Mouse CD248 Protein, His (Fc)-Avi-tagged	HEK293	His, Fc, Avi	18-695aa	Inquiry
Mouse	Cd248-5480M	Recombinant Mouse Cd248 Protein (Val19-Cys156), SUMO and Strep tagged	E.coli	SUMO and Strep	Val19-Cys156	Inquiry
Mouse	CD248-1447M-B	Recombinant Mouse CD248 Protein Pre-coupled Magnetic Beads	HEK293	His	18-695aa	Inquiry
Rhesus monkey	CD248-1628R	Recombinant Rhesus Monkey CD248 Protein	HEK293	His	18-687	Inquiry
Rhesus monkey	CD248-1630R	Recombinant Rhesus Monkey CD248 Protein, hIgG4-tagged	HEK293	hIgG4	18-687	Inquiry
Rhesus monkey	CD248-1629R	Recombinant Rhesus Monkey CD248 Protein, hIgG1-tagged	HEK293	Fc	18-687	Inquiry
Canine	CD248-1655C	Recombinant Canine CD248 protein, His-tagged	HEK293	C-His	Gln18-Gly687	Inquiry
Rhesus Macaque	CD248-731R	Recombinant Rhesus monkey CD248 Protein, His-tagged	Mammalian Cell	His	Full length or partial length	Inquiry
Rhesus Macaque	CD248-557R-B	Recombinant Rhesus Macaque CD248 Protein Pre-coupled Magnetic Beads	HEK293	His	1-685aa	Inquiry
Rhesus Macaque	CD248-557R	Recombinant Rhesus Macaque CD248 Protein, His (Fc)-Avi-tagged	HEK293	His, Fc, Avi	1-685aa	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

CD248 involved in several pathways and played different roles in them. We selected most pathways CD248 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CD248 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

CD248 has several biochemical functions, for example, calcium ion binding, carbohydrate binding, extracellular matrix binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD248 itself. We selected most functions CD248 had, and list some proteins which have the same functions with CD248. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	PCDHA2;PCDH1G31;PCDHGA12;CALML3;SWAP70B;PCDH2G5;PCDH12;ANXA2A;EGFL8
carbohydrate binding	CD209A;KRT1;CLEC2G;BCAN;ZG16B;LGALS3L;MLEC;NOMO1;MAN2B2
extracellular matrix binding	BGN;ITGA2B;DCN;ITGB3;SPP1;CD248;ITGAV;GPR56;TGFBI
molecular_function	FAM78AB;ARHGAP42;FAM82A1;AND4;VMN1R139;DISP2;NHLRC4;VMN1R111;ZFAND6

CD248 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD248 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD248.

TFAP2C

Research Area

Endothelial Cell Markers

Li, CS; Wang, JY; et al. Development, optimization, and validation of novel anti-TEM1/CD248 affinity agent for optical imaging in cancer. ONCOTARGET 5:6994-7012(2014).

Li, CS; Chacko, AM; et al. Antibody-based tumor vascular theranostics targeting endosialin/TEM1 in a new mouse tumor vascular model. CANCER BIOLOGY & THERAPY 15:443-451(2014).