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CDC27

  • Official Full Name

    CDC27 cell division cycle 27 homolog (S. cerevisiae)

  • Overview

    The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CDC27; cell division cycle 27 homolog (S. cerevisiae); APC3; HNUC; NUC2; ANAPC3; CDC27Hs; D0S1430E; D17S978E; cell division cycle protein 27 homolog; H-NUC; nuc2 homolog; CDC27 homolog; OTTHUMP00000232872; OTTHUMP00000232873; OTTHUMP00000232875; OTTHUMP00000232877; anaphase promoting complex subunit 3; anaphase-promoting complex subunit 3; anaphase-promoting complex, protein 3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDC27-11003H Recombinant Human CDC27, GST-tagged E.coli GST C-term-350a.a.
Human CDC27-0920H Recombinant Human CDC27 Protein, GST-Tagged Wheat Germ GST
Human CDC27-1271H Recombinant Human CDC27 protein, His & T7-tagged E.coli His/T7 Asn17~Ser231 (Accession # P30260)
Human CDC27-7662HCL Recombinant Human CDC27 293 Cell Lysate HEK293 N/A
Human CDC27-0704H Recombinant Human CDC27 Protein (Asn17-Ser231), N-His tagged E.coli N-His Asn17-Ser231
Human CDC27-3589H Recombinant Human CDC27 protein, His-tagged E.coli His 481-830 aa
Human CDC27-3071HF Recombinant Full Length Human CDC27 Protein, GST-tagged In Vitro Cell Free System GST 830 amino acids
Mouse CDC27-3135M Recombinant Mouse CDC27 Protein Mammalian Cell His
Mouse CDC27-1481M Recombinant Mouse CDC27 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CDC27-1481M-B Recombinant Mouse CDC27 Protein Pre-coupled Magnetic Beads HEK293
Rat CDC27-1274R Recombinant Rat CDC27 Protein Mammalian Cell His
Rat CDC27-932R-B Recombinant Rat CDC27 Protein Pre-coupled Magnetic Beads HEK293
Rat CDC27-932R Recombinant Rat CDC27 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CDC27-11496Z Recombinant Zebrafish CDC27 Mammalian Cell His
Chicken CDC27-1475C Recombinant Chicken CDC27 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CDC27 Related Articles

CDC27 involved in several pathways and played different roles in them. We selected most pathways CDC27 participated on our site, such as Cell cycle, Oocyte meiosis, Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDC27 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cell cycleYWHABA;E2F4;PLK4;TSGA14;ENSAA;NUMA1;TUBGCP2;KIF18A;APITD1
Oocyte meiosisFBXW11B;RPS6KA3A;CUL1;CALML5;ITPR1;CAMK2A;CPEB4;CAMK2B;CALM2B
Ubiquitin mediated proteolysisMDM2;UBE2QL1;MID1;TRIM37;UBE1Y1;FZR1A;BIRC2;CUL3B;RHOBTB1
Progesterone-mediated oocyte maturationPDE3B;GNAI2A;BUB1;PGR;RPS6KA1;CCNB2;RPS6KA3;MAPK9;IGF1
HTLV-I infectionIL1R1;HLA-DRB4;PDGFRB;DVL2;FZD1;HLA-DRB5;WNT16;DLG1;PPP3CB

CDC27 has several biochemical functions, for example, protein binding, protein phosphatase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDC27 itself. We selected most functions CDC27 had, and list some proteins which have the same functions with CDC27. You can find most of the proteins on our site.

Function Related Protein
protein bindingCCND2;RPS3A;CDC27;WHSC1L1;TMEM231;IWS1;C9orf43;ZDHHC17;AAK1
protein phosphatase bindingCSF1R;Itga10&Itgb1;VRK3;RPA3;ITGA1;MAP3K5;PIK3R1;CDH5;EIF2AK3

CDC27 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDC27 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDC27.

CDC20; FZR1; BUB1B; CDC16

Kraft, C; Herzog, F; et al. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. EMBO JOURNAL 22:6598-6609(2003).
Tokumoto, T; Tokumoto, M; et al. Purification of anaphase promoting complex/cyclosome from goldfish oocytes. FISH PHYSIOLOGY AND BIOCHEMISTRY 28:371-371(2003).
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