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Official Full Name cadherin 12, type 2 (N-cadherin 2)
Background This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.
Synonyms CDH12; cadherin 12, type 2 (N-cadherin 2); cadherin-12; Br cadherin; CDHB; Br-cadherin; N-cadherin 2; brain cadherin; brain-cadherin; neuronal cadherin 2; neural type cadherin 2; cadherin, neural type, 2; FLJ34857
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • Human Cell
    • Mammalian Cell
    • Mouse
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAB11506MH Mouse Anti-Human Cadherin 12, Type 2 Monoclonal Antibody Mouse N/A
    Human CDH12-0973H Recombinant Human CDH12 Protein, GST-Tagged Wheat Germ GST
    Human CDH12-1256H Recombinant Human CDH12 Protein (56-605 aa), His-tagged E.coli His
    Human CDH12-2230H Recombinant Human CDH12, His tagged Human Cell His
    Human CDH12-2625HCL Recombinant Human CDH12 cell lysate Human Cell N/A
    Human CDH12-26803TH Recombinant Human CDH12 Wheat Germ N/A
    Mouse CDH12-3165M Recombinant Mouse CDH12 Protein Mammalian Cell His

    cdh12 involved in several pathways and played different roles in them. We selected most pathways cdh12 participated on our site, such as Adherens junctions interactions, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with cdh12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adherens junctions interactions CDH6; CTNNB1; CDH3; CDH18A; PVRL2L; CDH17; CDH7; JUPA; CDH11; CADM2A
    Cell junction organization JUP; FBLIM1; PVRL1A; CDH24; CDH2; PARVB; CLDN20; CDH7; FERMT2; CDH10A
    Cell-Cell communication COL17A1; ITGB1B.1; CADM2; CLDN16; COL17A1A; FERMT2; CLDN4; CLDN7; CDH5; SKAP2
    Cell-cell junction organization CDH6; F11R.2; CADM2A; PVRL1A; CDH7; CDH18A; CDH5; CDH13; CLDN23; JUP

    cdh12 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cdh12 itself. We selected most functions cdh12 had, and list some proteins which have the same functions with cdh12. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding CAPNS1; SYT1A; DNER; DST; PROC; NCALDB; PEF1; MMP13; ZZEF1; RCN3

    cdh12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cdh12 here. Most of them are supplied by our site. Hope this information will be useful for your research of cdh12.


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