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CENPJ

Official Full Name

centromere protein J
Overview

This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
Synonyms

CENPJ; centromere protein J; LAP; CPAP; LIP1; BM032; MCPH6; SASS4; SCKL4; Sas-4; CENP-J; LAG-3-associated protein; LYST-interacting protein 1; LYST-interacting protein LIP1; LYST-interacting protein LIP7; centrosomal P4.1-associated protein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CENPJ-11097H	Recombinant Human CENPJ, GST-tagged	E.coli	GST	C-term-306a.a.	$319 / 25ug
Human	CENPJ-1118H	Recombinant Human CENPJ Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CENPJ-7583HCL	Recombinant Human CENPJ 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CENPJ-3321HF	Recombinant Full Length Human CENPJ Protein, GST-tagged	In Vitro Cell Free System	GST	372 amino acids	Inquiry
Human	CENPJ-466H	Recombinant Human CENPJ Protein, His-tagged	E.coli	His	Met1~Asn207	Inquiry
Mouse	CENPJ-3287M	Recombinant Mouse CENPJ Protein	Mammalian Cell	His		Inquiry
Mouse	CENPJ-1579M-B	Recombinant Mouse CENPJ Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	CENPJ-1579M	Recombinant Mouse CENPJ Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	Cenpj-467M	Recombinant Mouse Cenpj Protein, His-tagged	E.coli	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CENPJ Related Articles

CENPJ involved in several pathways and played different roles in them. We selected most pathways CENPJ participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with CENPJ were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Anchoring of the basal body to the plasma membrane	CSNK1E;CEP290;MAPRE1A;TUBG1;FBF1;NPHP4;ODF2;NPHP1;TCTN3
Assembly of the primary cilium	AKAP9;FGFR1OP;DYNLL2;PCM1;ACTR1A;MAPRE1B;ARL13B;CCT2;CEP89
Cell Cycle	RB1;SPDL1;PANE1;NINL;STAG1;H3F3B.1;ENSAA;RCC2;RAD21
Cell Cycle, Mitotic	ERCC6L;CEP57;LMNB1;ZW10;ESCO1;CENPC1;CDK11A;ZWILCH;OFD1
Centrosome maturation	CENPJ;ACTR1A;CEP76;CDK11B;TUBGCP4;CEP78;TUBGCP5;DCTN1;CSNK1E
G2/M Transition	CENPJ;BORA;NUMA1;FOXM1;NEDD1;CEP290;TUBGCP2;CLASP1;DCTN1
Loss of Nlp from mitotic centrosomes	NINL;PLK4;CENPJ;CEP57;CEP63;ODF2;CCP110;CEP290;PCM1
Loss of proteins required for interphase microtubule organizationfrom the centrosome	NEDD1;CKAP5;NDE1;MAPRE1;CEP152;CCP110;SDCCAG8;CEP135;MAPRE1B

CENPJ has several biochemical functions, for example, protein binding, protein domain specific binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CENPJ itself. We selected most functions CENPJ had, and list some proteins which have the same functions with CENPJ. You can find most of the proteins on our site.

Function	Related Protein
protein binding	DNAJB6;FAM90A1;KCNE4;PELP1;STEAP3;SRSF1;SCN5A;INTS12;SNF8
protein domain specific binding	ARL1;HOXB1;YWHAG;TJP2;SCAF1;ICAL1;YWHAH;FOXA1;RAP2B
protein kinase binding	TNIP2;ELAVL1;GATA6;BAG5;PRKAB1;CD226;TENC1;ADAM10;CCNE1
tubulin binding	TBCA;AGBL5;BIRC5;STMN3;MTAP4;TBCC;STMN2A;AGTPBP1;TPPP

CENPJ has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CENPJ here. Most of them are supplied by our site. Hope this information will be useful for your research of CENPJ.

CEP135; STIL

Song, G; Hu, CJ; et al. New Centromere Autoantigens Identified in Systemic Sclerosis Using Centromere Protein Microarrays. JOURNAL OF RHEUMATOLOGY 40:461-468(2013).

Hanke, K; Becker, MO; et al. Anticentromere-A and Anticentromere-B Antibodies Show High Concordance and Similar Clinical Associations in Patients with Systemic Sclerosis. JOURNAL OF RHEUMATOLOGY 37:2548-2552(2010).