Recombinant Human CENPJ Protein, GST-Tagged

• Cat.No.: CENPJ-1118H
• Product Overview: Human CENPJ full-length ORF (AAH24209.3, 1 a.a. - 372 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and mental retardation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 69.6 kDa
• AA Sequence: MRKLQKERKVFEKYTTAARTFPDKK EREEIQTLKQQIADLREDLKRKETK WSSTHSRLRSQIQMLVRENTDLREE IKVMERFRLDAWKRAEAIESSLEVE KKDKLANTSVRFQNSQISSGTQVEK YKKNYLPMQGNPPRRSKSAPPRDLG NLDKGQAASPREPLEPLNFPDPEYK EEEEDQDIQGEISHPDGKVEKVYKN GCRVILFPNGTRKEVSADGKTITVT FFNGDVKQVMPDQRVIYYYAAAQTT HTTYPEGLEVLHFSSGQIEKHYPDG RKEITFPDQTVKNLFPDGQEESIFP DGTIVRVQRDGNKLIEFNNGQRELH TAQFKRREYPDGTVKTVYANGHQET KYRSGRIRVKDKEGNVLMDTEL
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: CENPJ centromere protein J [ Homo sapiens ]
• Official Symbol: CENPJ
• Synonyms: CENPJ; centromere protein J; MCPH6, microcephaly, primary autosomal recessive 6; BM032; CPAP; LAP; LIP1; Sas 4; SASS4; SCKL4; LAG-3-associated protein; LYST-interacting protein 1; LYST-interacting protein LIP1; LYST-interacting protein LIP7; centrosomal P4.1-associated protein; MCPH6; Sas-4; CENP-J; MGC131581; MGC131582; MGC142222; MGC142224
• Gene ID: 55835
• mRNA Refseq: NM_018451
• Protein Refseq: NP_060921
• MIM: 609279
• UniProt ID: Q9HC77