CFB

Official Full Name

complement factor B
Overview

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
Synonyms

CFB; complement factor B; BF; FB; BFD; GBG; CFAB; PBF2; AHUS4; FBI12; H2-Bf; FLJ54899; C3 proactivator; C3/C5 convertase; C3 proaccelerator; OTTHUMP00000029283; properdin factor B; B-factor, properdin; glycine-rich beta glycoprotein; glycine-rich beta-glycoprotein;

Type

Recombinant Proteins
Cell & Tissue Lysates
Native Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat
Rhesus monkey
Zebrafish

Source

E.coli
HEK293
HEK293EBNA2
HEK293T
In Vitro Cell Free System
Insect Cell
Mammalian Cell
Mammalian cells
Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II)
Wheat Germ

Tag

Flag
GST
His
Fc
Avi
MBP
Myc
DDK
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CFB-2106H	Recombinant Human CFB protein, His & GST-tagged	E.coli	His&GST	Gly35~Asn160	Inquiry
Human	CFB-26760TH	Recombinant Human CFB, His-tagged	E.coli	His	77-764	Inquiry
Human	CFB-444H	Recombinant Human complement factor B, His-tagged	E.coli	His		Inquiry
Human	CFB-11132H	Recombinant Human CFB, GST-tagged	E.coli	GST	573-761a.a.	$319 / 25μg
Human	CFB-26762TH	Recombinant Human CFB, His-tagged		His		Inquiry
Human	CFB-Bb-2479H	Recombinant human CFB-Bb, His-tagged	E.coli	His		Inquiry
Human	CFB-141H	Recombinant Human CFB protein, His-tagged	Insect Cell	His	26-259	Inquiry
Human	CFB-1161H	Recombinant Human CFB Protein, His-Tagged	HEK293EBNA2	His		Inquiry
Human	CFB-1162H	Recombinant Human CFB Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CFB-7558HCL	Recombinant Human CFB 293 Cell Lysate	HEK293	Non		Inquiry
Human	CFB-334H	Recombinant Human CFB Protein, His-tagged	HEK293	His	Met1-Leu764	Inquiry
Human	CFB-104H	Native Human Factor B	Normal human serum (shown by certified tests to be negative for HBsAg, HTLV-I/II, STS and for antibodies to HCV, HIV-1 and HIV-II)	Non		Inquiry
Human	CFB-834HFL	Recombinant Full Length Human CFB Protein, C-Flag-tagged	Mammalian cells	Flag		Inquiry
Human	CFB-3292HF	Recombinant Full Length Human CFB Protein, GST-tagged	In Vitro Cell Free System	GST	764 amino acids	Inquiry
Human	CFB-755H	Recombinant Human CFB Protein, His-tagged	E.coli	His	Lys260-Leu764	Inquiry
Human	CFB-756H	Recombinant Human CFB Protein, His-tagged	E.coli	His	Gly35-Asn160	Inquiry
Human	CFB-583H	Recombinant Human CFB Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	CFB-1382H	Recombinant Human CFB Protein (Tyr573-Leu761), N-His tagged	E.coli	His	Tyr573-Leu761	Inquiry
Human	CFB-583H-B	Recombinant Human CFB Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Human	CFB-2186H	Recombinant Human CFB Protein (Thr26-Leu764), C-His tagged	Mammalian cells	His	Thr26-Leu764	Inquiry
Mouse	Cfb-2107M	Recombinant Mouse Cfb protein, His-tagged	E.coli	His	Val32~Asp157	Inquiry
Mouse	CFB-1164M	Recombinant Mouse CFB Protein, His-tagged	E.coli	His	23-761	Inquiry
Mouse	Cfb-758M	Recombinant Mouse Cfb Protein, His-tagged	E.coli	His	Val32-Asp157	Inquiry
Mouse	Cfb-1085M	Recombinant Mouse Cfb Protein, MYC/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Mouse	Cfb-759M	Recombinant Mouse Cfb Protein, His-tagged	E.coli	His	Thr25-Arg258	Inquiry
Rat	Cfb-2110R	Recombinant Rat Cfb protein, His & MBP-tagged	E.coli	His&MBP	Val34~Asp159	Inquiry
Rat	Cfb-2109R	Recombinant Rat Cfb protein, His & GST-tagged	E.coli	His&GST	Val34~Asp159	Inquiry
Rat	Cfb-2108R	Recombinant Rat Cfb protein, His-tagged	E.coli	His	Asn269~Val382	Inquiry
Rhesus monkey	CFB-757R	Recombinant Rhesus monkey CFB Protein, His-tagged	E.coli	His	Asn270-Thr388	Inquiry
Zebrafish	CFB-8924Z	Recombinant Zebrafish CFB	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

CFB involved in several pathways and played different roles in them. We selected most pathways CFB participated on our site, such as Complement and coagulation cascades, Staphylococcus aureus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CFB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Complement and coagulation cascades	FGG;CD59A;C6;SERPINC1;CPB2;C1QC;FGA;MASP1;F11
Staphylococcus aureus infection	HLA-DRB1;HLA-DRB5;HLA-DPA1;cgr2b;C2;ITGB2;HLA-DRB3;FCGR2B;Hc

CFB has several biochemical functions, for example, complement binding, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CFB itself. We selected most functions CFB had, and list some proteins which have the same functions with CFB. You can find most of the proteins on our site.

Function	Related Protein
complement binding	CD46;CFB;CR2;C8G;C8A;CD59
serine-type endopeptidase activity	PRSS57;Acr;KLK6;CELA2A;HTRA1;EGFBP2;F9B;F12;TPP1

CFB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFB here. Most of them are supplied by our site. Hope this information will be useful for your research of CFB.

vco3_najka; RPA2; LAMC3; d-mannose; ALB; Nedd1

Research Area

Alternative Complement Pathway

Complement Regulatory Proteins

Szarvas, N; Szilagyi, A; et al. First-line therapy in atypical hemolytic uremic syndrome: consideration on infants with a poor prognosis. ITALIAN JOURNAL OF PEDIATRICS 40:-(2014).

Yamamoto, K; Takeuchi, T; et al. Efficacy and safety of certolizumab pegol without methotrexate co-administration in Japanese patients with active rheumatoid arthritis: The HIKARI randomized, placebo-controlled trial. MODERN RHEUMATOLOGY 24:552-560(2014).