CFHR1

Official Full Name

complement factor H-related 1
Overview

This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
Synonyms

CFHR1; complement factor H-related 1; CFHL1, CFHL1P, CFHR1P, complement factor H related 1 pseudogene , H factor (complement) like 1 , H factor (complement) like 2 , HFL1, HFL2; complement factor H-related protein 1; CFHL; FHR1; H36 1; H36 2; CFHL1; CFHL1P; CFHR1P; Complement factor H related 1 pseudogene; Complement factor H related protein 1 precursor; FHR 1; FHR-1; FHR1_HUMAN; H factor (complement) like 1; H factor (complement) like 2; H factor like protein 1; H factor-like protein 1; H-factor-like 1; H36; HFL1; HFL2; MGC104329; H factor (complement)-like 1; H factor (complement)-like 2; complement factor H-related 1 pseudogene; H36-1; H36-2;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Zebrafish

Source

E. coli
E.coli
HEK293
Human Cell
Mammalian Cell
Mammalian cells
Wheat Germ

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CFHR1-27138TH	Recombinant Human CFHR1 protein, GST-tagged	Wheat Germ	GST	19-330	$198 / 2μg
Human	CFHR1-8555H	Recombinant Human CFHR1 protein(Met1-Arg330), His-tagged	HEK293	His	Met1-Arg330	Inquiry
Human	CFHR1-268H	Recombinant Human CFHR1, His-tagged	HEK293	C-His	Glu19-Arg330	Inquiry
Human	CFHR1-269H	Recombinant Human CFHR1, His-tagged	Mammalian Cell	Non	Glu19-Arg330	Inquiry
Human	CFHR1-1289HCL	Recombinant Human CFHR1 cell lysate	Human Cell	Non		Inquiry
Human	CFHR1-2819H	Recombinant Human CFHR1 protein(132-221aa), His-GST&Myc-tagged	E. coli	N-His-GST&C-Myc	132-221aa	Inquiry
Human	CFHR1-764H	Recombinant Human CFHR1 Protein, His-tagged	E.coli	His	Thr205-Lys329	Inquiry
Human	CFHR1-1000H	Recombinant Human CFHR1 Protein (Glu19-Arg330), C-His tagged	Mammalian cells	His	Glu19-Arg330	Inquiry
Zebrafish	CFHL1-3595Z	Recombinant Zebrafish CFHL1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

CFHR1 involved in several pathways and played different roles in them. We selected most pathways CFHR1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CFHR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

CFHR1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CFHR1 itself. We selected most functions CFHR1 had, and list some proteins which have the same functions with CFHR1. You can find most of the proteins on our site.

Function	Related Protein

CFHR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CFHR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CFHR1.

PRDX4

Research Area

Complement Regulatory Proteins

Serine Proteases and Regulators

Khandelwal, P; Gupta, A; et al. Effect of plasma exchange and immunosuppressive medications on antibody titers and outcome in anti-complement factor H antibody-associated hemolytic uremic syndrome. PEDIATRIC NEPHROLOGY 30:451-457(2015).

Caesar, JJE; Lavender, H; et al. Competition between antagonistic complement factors for a single protein on N-meningitidis rules disease susceptibility. ELIFE 3:-(2014).