CHKA

  • Official Full Name

    choline kinase alpha
  • Overview

    The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    CHKA;choline kinase alpha;CK;EK;CHK;CKI;CHETK-alpha;ethanolamine kinase

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • P.falciparum
  • Mouse
  • Wheat Germ
  • Mammalian Cells
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
CHKA-1240H Recombinant Human CHKA Protein, GST-Tagged Wheat Germ Human GST
CHKA-1373R Recombinant Rat CHKA Protein Mammalian Cells Rat His
CHKA-26903TH Recombinant Human CHKA Wheat Germ Human Non 457 amino acids
CHKA-3986Z Recombinant Zebrafish CHKA Mammalian Cells Zebrafish His
CHKA-5269H Recombinant Human CHKA Protein E.coli Human Non Full L.
CHKA-5270P Recombinant P. falciparum CHKA Protein E.coli P.falciparum Non Full L.
CHKA-65H Recombinant Human CHKA, MYC/DDK-tagged HEK293 Human DDK&Myc
CHKA-7535HCL Recombinant Human CHKA 293 Cell Lysate HEK293 Human Non
CHKA-1031R Recombinant Rat CHKA Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
CHKA-1031R-B Recombinant Rat CHKA Protein Pre-coupled Magnetic Beads HEK293 Rat
Chka-1659M Recombinant Mouse Chka protein, His & GST-tagged E.coli Mouse GST&His Met1~Glu250
CHKA-3201HF Recombinant Full Length Human CHKA Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 457 amino acids
CHKA-5412H Recombinant Human CHKA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
CHKA-77HF Recombinant Full Length Human CHKA Protein In Vitro Cell Free System Human Full L. 457 amino acids
CHKA-8874HFL Recombinant Full Length Human CHKA, Flag-tagged Mammalian Cells Human Flag Full L.
Chka-889M Recombinant Mouse Chka Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    CHKA involved in several pathways and played different roles in them. We selected most pathways CHKA participated on our site, such as Acetylcholine Synthesis,Choline metabolism in cancer,Glycerophospholipid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Choline metabolism in cancer DGKD,DGKG,PIP5K1C,PIK3CG,RPS6KB1,MAPK9,MAPK10,HIF1A,HRAS,MAP2K2
    Glycerophospholipid biosynthesis PHOSPHO1,BCHE,AGPAT6,AGPAT2,PTPMT1,DGAT1B,CPNE6,PLA2G16,CDS1,CPNE7
    Acetylcholine Synthesis CHAT,PEMT
    Glycerophospholipid metabolism ETNK2,AGPAT1,PHOSPHO1,PLA2G15,PLA2G4F,ACHE,PCYT1A,PEMT,AGPAT4,PLA2G4D
    Phospholipid metabolism ARF3,PHOSPHO1,CPNE3,FIG4,PLBD1,PITPNB,SACM1L,AWAT1,SLC44A5B,SACM1LB
    Metabolism PIK3R6,MTF1,PRKRA,SLC2A3,SULT1C4,LSM1,AK7,LYPLA1,SLC25A1A,NOSTRIN
    Metabolism of lipids and lipoproteins ALOX5B.3,FAM213B,GLTPD1,AWAT1,CERS4A,ACOT13,FABP11A,MED16,CYP4B1,NFYAL
    Metabolic pathways PGS1,EXT1,TDO2B,PLA2G6,DHRS4,EHHADH,NDUFB6,AGPAT5,ACSL3,BHMT

    Protein Function

    CHKA has several biochemical functions, for example, ATP binding,choline binding,choline kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHKA itself. We selected most functions CHKA had, and list some proteins which have the same functions with CHKA. You can find most of the proteins on our site.

    Function Related Protein
    choline binding BCHE,SLC5A7,CRP
    signal transducer activity TAAR8B,GNG7,GAB1,TAAR13C,PLCD1B,GNA13B,OLFCG1,TMED4,GNB5,TAAR12I
    cholinesterase activity CELL,BCHE,CEL.1,ACHE
    drug binding CHRNB4,DAAM2,Alb,CNR1,SETD6,P2RX1,DRD2,DHFR,IL2RA,HMGCS1
    ethanolamine kinase activity CHKB,ETNK2,ETNK1
    choline kinase activity CHKB
    protein homodimerization activity TIGIT,CEACAM5,CASQ2,INHBB,TPD52L2,UGT1A6A,NUDT16,NLRC4,IMPA1,S100A10
    ATP binding ROCK1,KIF3C,SMC2,NSFB,MYH4,UBE2D4,ERCC6L,ATP8B1,CLP1,PRKAA1

    Interacting Protein

    CHKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHKA here. Most of them are supplied by our site. Hope this information will be useful for your research of CHKA.

    FCHSD2

    Resources

    References

    • Gaillard, F; Kuny, S; et al. Retinal distribution of Disabled-1 in a diurnal murine rodent, the Nile grass rat Arvicanthis niloticus. EXPERIMENTAL EYE RESEARCH 125:236-243(2014).
    • Kalashnyk, O; Lykhmus, O; et al. alpha 7 Nicotinic acetylcholine receptor-specific antibody stimulates interleukin-6 production in human astrocytes through p38-dependent pathway. INTERNATIONAL IMMUNOPHARMACOLOGY 23:475-479(2014).

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