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Official Full Name choline kinase beta
Background Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus.
Synonyms CHKB; choline kinase beta; CHKL, choline kinase like; choline/ethanolamine kinase; CHETK; Chetk-beta; Chkb choline kinase beta; Chkb protein; CHKB_HUMAN; CHKL; Choline kinase-like; Choline kinase-like protein; choline/ethanolamine kinase beta; Choline/ethanolamine kinase, beta; CK; CK/EK; CK/EK-beta; CKB; CKEKB; EK; EKB; Ethanolamine kinase; Ethanolamine kinase beta; Ethanolamine kinase, beta; MDCMC
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CHKB-1243H Recombinant Human CHKB Protein, GST-Tagged Wheat Germ GST
    Human CHKB-26715TH Recombinant Human CHKB Wheat Germ N/A
    Human CHKB-35H Recombinant Human CHKB protein E.coli N/A
    Human CHKB-4578H Recombinant Human CHKB Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CHKB-7534HCL Recombinant Human CHKB 293 Cell Lysate HEK293 N/A
    Mouse Chkb-1726M Recombinant Mouse Chkb protein, His-tagged E.coli His
    Mouse CHKB-3399M Recombinant Mouse CHKB Protein Mammalian Cell His
    Mouse Chkb-885M Recombinant Mouse Chkb Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CHKB-1374R Recombinant Rat CHKB Protein Mammalian Cell His
    Zebrafish CHKB-5818Z Recombinant Zebrafish CHKB Mammalian Cell His

    chkb involved in several pathways and played different roles in them. We selected most pathways chkb participated on our site, such as Choline metabolism in cancer, Fatty Acid Beta Oxidation, Glycerophospholipid biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with chkb were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Choline metabolism in cancer HIF1A; RHEB; SLC22A3; PIK3CG; PRKCG; DGKG; PIK3R1; WASF2; SLC44A2; PLD2
    Fatty Acid Beta Oxidation CPT1B; CPT2; SLC25A20; ECI1; CHKB; CRAT; CPT1A; DECR1
    Glycerophospholipid biosynthesis CPNE7; PLA2G16; PLBD1; CPNE1; BCHE; CHKA; CPNE6; AGPAT1; CEPT1; CPNE3
    Glycerophospholipid metabolism AGPAT3; PLD1; LPCAT2; AGXT2L1; LPIN1; PHYKPL; GPD1; PLA2G2E; CRLS1; TESCA
    Metabolic pathways CYP21A1; NDUFA13; ARSB; GUK1B; GATB; ST20-MTHFS; CKMA; NAT2; MBOAT1; ASAH2
    Metabolism COQ7; CIAPIN1; PLB1; B4GALT7; CYP24A1; DBH; CYP2K19; GCKR; IVD; MED23
    Metabolism of lipids and lipoproteins COQ7; APOF; FABP12; SGMS2; SACM1LA; ACOT9.1; ABHD4; MED26; CPNE6; CPNE3
    Phospholipid metabolism ARF3; SACM1L; PITPNB; PLBD1; CPNE1; CPNE7; PEMT; ABHD4; SACM1LB; TPTE

    chkb has several biochemical functions, for example, ATP binding, choline kinase activity, ethanolamine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by chkb itself. We selected most functions chkb had, and list some proteins which have the same functions with chkb. You can find most of the proteins on our site.

    Function Related Protein
    choline kinase activity CHKB; CHKA
    ethanolamine kinase activity ETNK2; CHKB; ETNK1; CHKA

    chkb has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with chkb here. Most of them are supplied by our site. Hope this information will be useful for your research of chkb.


    Yang, L; Roh, YS; et al. Transforming Growth Factor Beta Signaling in Hepatocytes Participates in Steatohepatitis Through Regulation of Cell Death and Lipid Metabolism in Mice. HEPATOLOGY 59:483-495(2014).
    Gruber, J; Too, WCS; et al. Balance of human choline kinase isoforms is critical for cell cycle regulation Implications for the development of choline kinase-targeted cancer therapy. FEBS JOURNAL 279:1915-1928(2012).

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