CHMP4B
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Official Full Name
charged multivesicular body protein 4B -
Overview
This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts. -
Synonyms
CHMP4B;charged multivesicular body protein 4B;C20orf178, chromatin modifying protein 4B , chromosome 20 open reading frame 178;dJ553F4.4;Shax1;SNF7 2;VPS32B;hSnf7-2;hVps32-2;chromatin modifying protein 4B
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Strep
- Avi
- Fc
- DDK
- Myc
- Flag
Involved Pathway
CHMP4B involved in several pathways and played different roles in them. We selected most pathways CHMP4B participated on our site, such as Budding and maturation of HIV virion,Cellular responses to stress,Disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHMP4B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Budding and maturation of HIV virion | PDCD6IP,gag,PPIA,VPS37A,CHMP4C |
| Endocytosis | ARF3,DNM2,RAB11FIP3,GRK7,SPG20A,MHC1UEA,HSPA8,KDRL,ARF1L,CDC42L2 |
| HIV Life Cycle | NMT2,RCC1,CDK9,PDCD6IP,TCEB3,VPS37A,ELL,TAF1L,PSTPIP2,PSIP1 |
| Cellular responses to stress | SCMH1,WIPI1,C11orf73,KAT5,PHC3,ACD,HIF1AL,HMGA1,Txn1,TERF1 |
| Infectious disease | KPNA5,AP1M2,APOBEC3G,PPIAL4A,VPS37A,KPNA3,SYT2,AP1S1,NMT1,PACS1 |
| Disease | KERA,OPN1MW2,FGFR1OP2,CDK9,LRRFIP1,GPC6,NA,TIRAP,GYG1,SSRP1 |
| Endosomal Sorting Complex Required For Transport (ESCRT) | VPS37A,CHMP4C,SNF8,STAM2 |
| HIV Infection | APOBEC3G,PSTPIP2,TCEB3,VPS37A,AP1M2,CHMP4C,AP1G1,RCC1,NMT2,AP1B1 |
Protein Function
CHMP4B has several biochemical functions, for example, identical protein binding,protein binding,protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHMP4B itself. We selected most functions CHMP4B had, and list some proteins which have the same functions with CHMP4B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | MCIN,PAFAH1B3,MICALL1,JMJD6,C1QL4,SQSTM1,ACY3,CEP57L1,C14orf166,TP73 |
| protein binding | IFI6,SNX15,RPH3A,KIF2A,TTK,GIMAP7,HTN1,STRN,SP1,FERMT2 |
| protein homodimerization activity | IRAK3,GRIK2,NCR3,PVRL1,MUC13,CLN6,ANXA9,PRTFDC1,ANO2,STK10 |
Interacting Protein
CHMP4B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHMP4B here. Most of them are supplied by our site. Hope this information will be useful for your research of CHMP4B.
ATP6V1A;PTPN23;USP8;USP54;PRKAR1A;Chmp3;STAMBP;HTT;UBE2I;Baz2b;1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate;TCEB1;e9psi1_human;TAF1;AIM2;CHMP2A
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