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CHST6

  • Official Full Name

    carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6

  • Overview

    The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD).
  • Synonyms

    CHST6; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6; MCDC1; carbohydrate sulfotransferase 6; C GlcNAc6ST; Carbohydate sulfotransferase 6; Carbohydrate (N acetylglucosamine 6 O) sulfotransferase 6; Corneal N acetylglucosamine 6 sulfotransferase; Galactose N acetylglucosamine N acetylglucosamine 6 O sulfotransferase 4 beta; GlcNAc6ST 5; GST4 beta; hCGn6ST; Macular dystrophy corneal 1; gn6st-5; GST4-beta; C-GlcNAc6ST; glcNAc6ST-5; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sulfotransferase; corneal N-acetylglucosamine-6-O-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • CHO
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CHST6-738H Active Recombinant Human CHST6 Protein, His-tagged CHO His Ser27-Asn395
Human CHST6-327H Recombinant Human CHST6 Protein, His-tagged E.coli His
Human CHST6-1347H Recombinant Human CHST6 Protein, GST-tagged Wheat Germ GST
Human CHST6-7506HCL Recombinant Human CHST6 293 Cell Lysate HEK293 N/A
Human CHST6-2716H Recombinant Human CHST6 protein, His-tagged E.coli His 211-287 aa
Chicken CHST6-5464C Recombinant Chicken CHST6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CHST6 involved in several pathways and played different roles in them. We selected most pathways CHST6 participated on our site, such as Glycosaminoglycan biosynthesis - keratan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHST6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Glycosaminoglycan biosynthesis - keratan sulfateFUT8;Chst5;B3GNT2B;B4GALT2;B4GALT1;ST3GAL2;B3GNT1;B3GNT7;B3GNT2

CHST6 has several biochemical functions, for example, N-acetylglucosamine 6-O-sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHST6 itself. We selected most functions CHST6 had, and list some proteins which have the same functions with CHST6. You can find most of the proteins on our site.

Function Related Protein
N-acetylglucosamine 6-O-sulfotransferase activitySULT1ST7;SULT1ST4;SULT2ST1;HS3ST3B1A;CHST6;SULT3ST2;CHST2;SULT1D1;HS3ST1L1

CHST6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHST6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHST6.

Research Area

Related articles

Nakayama, F; Umeda, S; et al. Sulfation of keratan sulfate proteoglycan reduces radiation-induced apoptosis in human Burkitt's lymphoma cell lines. FEBS LETTERS 587:231-237(2013).
Di Iorio, E; Barbaro, V; et al. Localization and expression of CHST6 and keratan sulfate proteoglycans in the human cornea. EXPERIMENTAL EYE RESEARCH 91:293-299(2010).
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