CHST6

Official Full Name

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6
Background

The protein encoded by this gene is an enzyme that catalyzes the transfer of a sulfate group to the GlcNAc residues of keratan. Keratan sulfate helps maintain corneal transparency. Defects in this gene are a cause of macular corneal dystrophy (MCD).
Synonyms

CHST6; carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 6; MCDC1; carbohydrate sulfotransferase 6; C GlcNAc6ST; Carbohydate sulfotransferase 6; Carbohydrate (N acetylglucosamine 6 O) sulfotransferase 6; Corneal N acetylglucosamine 6 sulfotransferase; Galactose N acetylglucosamine N acetylglucosamine 6 O sulfotransferase 4 beta; GlcNAc6ST 5; GST4 beta; hCGn6ST; Macular dystrophy corneal 1; gn6st-5; GST4-beta; C-GlcNAc6ST; glcNAc6ST-5; N-acetylglucosamine 6-O-sulfotransferase 5; corneal N-acetylglucosamine 6-sulfotransferase; corneal N-acetylglucosamine-6-O-sulfotransferase; galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 4-beta;

Type:
Recombinant Proteins
Cell & Tissue Lysates

Species :
Chicken
Human

Source :
CHO
E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag :
GST
His
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Human	CHST6-738H	Active Recombinant Human CHST6 Protein, His-tagged	CHO	His	Inquiry
Human	CHST6-327H	Recombinant Human CHST6 Protein, His-tagged	E.coli	His	Inquiry
Human	CHST6-1347H	Recombinant Human CHST6 Protein, GST-tagged	Wheat Germ	GST	Inquiry
Human	CHST6-7506HCL	Recombinant Human CHST6 293 Cell Lysate	HEK293	N/A	Inquiry
Human	CHST6-2716H	Recombinant Human CHST6 protein, His-tagged	E.coli	His	$319.00 / 25ug
Chicken	CHST6-5464C	Recombinant Chicken CHST6	Mammalian Cell	His	Inquiry

Involved Pathway
Protein Function
Interacting Protein
CHST6 Related Articles

CHST6 involved in several pathways and played different roles in them. We selected most pathways CHST6 participated on our site, such as Glycosaminoglycan biosynthesis - keratan sulfate, which may be useful for your reference. Also, other proteins which involved in the same pathway with CHST6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Glycosaminoglycan biosynthesis - keratan sulfate	B3GNT2B;FUT8A;B4GALT4;ST3GAL1;CHST6;ST3GAL3;B4GALT2;B3GNT1;B3GNT7

CHST6 has several biochemical functions, for example, N-acetylglucosamine 6-O-sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CHST6 itself. We selected most functions CHST6 had, and list some proteins which have the same functions with CHST6. You can find most of the proteins on our site.

Function	Related Protein
N-acetylglucosamine 6-O-sulfotransferase activity	CHST1;SULT1ST1;HS3ST3B1A;SULT5A1;CHST3;SULT2ST3;SULT3ST4;SULT2ST2;CHST3B

CHST6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CHST6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CHST6.

Nakayama, F; Umeda, S; et al. Sulfation of keratan sulfate proteoglycan reduces radiation-induced apoptosis in human Burkitt's lymphoma cell lines. FEBS LETTERS 587:231-237(2013).

Di Iorio, E; Barbaro, V; et al. Localization and expression of CHST6 and keratan sulfate proteoglycans in the human cornea. EXPERIMENTAL EYE RESEARCH 91:293-299(2010).