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CIT

Official Full Name

citron (rho-interacting, serine/threonine kinase 21)
Overview

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.
Synonyms

CIT; citron (rho-interacting, serine/threonine kinase 21); citron Rho-interacting kinase; CRIK; KIAA0949; STK21; serine/threonine-protein kinase 21;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CIT-827H	Active Recombinant Human CIT, GST-tagged	Sf9 Insect Cell	GST	1-449	Inquiry
Human	CIT-1384H	Recombinant Human CIT Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CIT-1383H	Active Recombinant Human CIT Protein, GST-tagged	Insect Cell	GST		Inquiry

Involved Pathway
Protein Function
Interacting Protein
CIT Related Articles

CIT involved in several pathways and played different roles in them. We selected most pathways CIT participated on our site, such as G13 Signaling Pathway, RHO GTPase Effectors, RHO GTPases activate CIT, which may be useful for your reference. Also, other proteins which involved in the same pathway with CIT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
G13 Signaling Pathway	CFL2;MYL1;GNA13;MYBPH;CIT;RHPN2;SH3RF1;TNK2;RTKN
RHO GTPase Effectors	MKL1B;ZW10;NOXO1;NOXA1;SPC24;LIN7B;SGOL2;KLC3;KNTC1
RHO GTPases activate CIT	PRC1B;KIF14;CIT;RHOAE;PRC1
Signal Transduction	MKL1B;ARHGAP12;OR52J3;RHOJ;ADAM12;RXFP2B;EMR4;SHRPRBCK1R;WDR19
Signaling by Rho GTPases	GDI2;FMNL1;FGD4;IQGAP3;PRC1;NOXO1A;ARHGAP4A;ARHGAP17A;WIPF3

CIT has several biochemical functions, for example, ATP binding, PDZ domain binding, SH3 domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CIT itself. We selected most functions CIT had, and list some proteins which have the same functions with CIT. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	AASDH;ATP1A3B;PNKP;TBCK;MTHFS;UBE2E1;NUBP2;ACSBG2;RPS6KA4
PDZ domain binding	PTENA;ATP2B3B;CIT;SLC22A12;FZD1;CFTR;NKD1;ERC1;GNG12
SH3 domain binding	MICAL1;PTPN22;ADAM15;SH3BP5B;DOCK4;NCF1;DNM2;ADAM9;KHDRBS1
metal ion binding	ACAP2;ZFP410;ZNF83;ZNF718;EXTL3;ARIH1L;AIFM3;VEZF1B;EXT2
protein binding	SLC6A18;EAF1;RND2;NAT8B;HIST1H3G;PHB2;NGLY1;FLOT1;DDR1
protein serine/threonine kinase activity	NUAK1;PAK2;STK38;RPS6KA1;STK11;ICK;NLK2;BMPR2B;SGK2A
scaffold protein binding	KRT8;KCNQ1;CHUK;CRIPT;SCN5A;PARK7;NLRP1;NLGN1;LRP4

CIT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CIT here. Most of them are supplied by our site. Hope this information will be useful for your research of CIT.

MYL12A

Xu, Y; Xiong, L; et al. Citrinin detection using phage-displayed anti-idiotypic single-domain antibody for antigen mimicry. FOOD CHEMISTRY 177:97-101(2015).

Uchiyama, MK; Deda, DK; et al. In vivo and In vitro Toxicity and Anti-Inflammatory Properties of Gold Nanoparticle Bioconjugates to the Vascular System. TOXICOLOGICAL SCIENCES 142:497-507(2014).