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Official Full Name chloride channel 1
Background The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which;demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded;by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two;forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia;(Thomsen). Alternative splicing results in multiple transcript variants.
Synonyms CLCN1; chloride channel 1; chloride channel protein 1; Chloride channel protein skeletal muscle; skeletal muscle; Chloride channel protein; CIC 1; CIC1; ClC-1; CLC1; CLCN1_HUMAN; MGC138361; MGC142055; OTTMUSP00000052750; OTTMUSP00000052753; OTTMUSP00000052757; arrested development of righting response; chloride channel protein, skeletal muscle; adr; mto; SMCC1; nmf355; myotonia
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLCN1-01HCL Recombinant Human CLCN1 cell lysate, Myc/DDK-tagged HEK293T Myc/DDK
    Human CLCN1-1414H Recombinant Human CLCN1 Protein, GST-tagged Wheat Germ GST
    Mouse CLCN1-3512M Recombinant Mouse CLCN1 Protein Mammalian Cell His
    Rat CLCN1-1424R Recombinant Rat CLCN1 Protein Mammalian Cell His

    clcn1 involved in several pathways and played different roles in them. We selected most pathways clcn1 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with clcn1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ion channel transport BEST3; WWP1; CLCN6; CLCN5; TPCN1; CLCN2; ATP13A1; TTYH3B; ATP13A5; ANO8
    Stimuli-sensing channels ANO10; MCOLN3; TRPM4A; TSC22D3; TRDN; TRPC5A; TRPC4A; CLIC2; SLC17A3; MCOLN2
    Transmembrane transport of small molecules RHCGB; SLC43A2; FTH1A; SLC41A1; SLC12A4; SLC26A6L; TRPC4B; GABRR2A; SLC5A3A; ATP1A1A.2

    clcn1 has several biochemical functions, for example, chloride channel activity, protein binding, voltage-gated chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by clcn1 itself. We selected most functions clcn1 had, and list some proteins which have the same functions with clcn1. You can find most of the proteins on our site.

    Function Related Protein
    chloride channel activity CLCNKB; SLC26A3.2; FXYD1; APOL1; SLC26A4; SLC26A5; CLCA5; FXYD3; SLC26A1; CLCC1
    protein binding BRD8; YARS2; KIAA0247; ZBTB1; HTATIP2; CLEC16A; IMPDH2; STK24; ROS1; MECOM
    voltage-gated chloride channel activity CLCNKA; CLCN1; CLCN1A; CLCN7; CLCN3; CLCN4-2; CLCNKB; CLCNK; CLCN5; CLCN6

    clcn1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with clcn1 here. Most of them are supplied by our site. Hope this information will be useful for your research of clcn1.


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