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Official Full Name chloride channel 7
Background The product of this gene belongs to the CLC chloride channel family of proteins. Chloride channels play important roles in the plasma membrane and in intracellular organelles. This gene encodes chloride channel 7. Defects in this gene are the cause of osteopetrosis autosomal recessive type 4 (OPTB4), also called infantile malignant osteopetrosis type 2 as well as the cause of autosomal dominant osteopetrosis type 2 (OPTA2), also called autosomal dominant Albers-Schonberg disease or marble disease autosoml dominant. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. OPTA2 is the most common form of osteopetrosis, occurring in adolescence or adulthood.
Synonyms CLCN7; chloride channel 7; H(+)/Cl(-) exchange transporter 7; CLC 7; CLC7; OPTA2; PPP1R63; protein phosphatase 1; regulatory subunit 63; Chloride channel protein 7; ClC-7; CLCN7_HUMAN; FLJ26686; FLJ39644; FLJ46423; OPTB4; protein phosphatase 1, regulatory subunit 63
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLCN7-11280H Recombinant Human CLCN7, GST-tagged E.coli GST
    Human CLCN7-1422H Recombinant Human CLCN7 Protein, GST-tagged Wheat Germ GST
    Human CLCN7-7472HCL Recombinant Human CLCN7 293 Cell Lysate HEK293 N/A
    Mouse CLCN7-3518M Recombinant Mouse CLCN7 Protein Mammalian Cell His
    Rat CLCN7-1428R Recombinant Rat CLCN7 Protein Mammalian Cell His
    Chicken CLCN7-2351C Recombinant Chicken CLCN7 Mammalian Cell His
    Zebrafish CLCN7-4750Z Recombinant Zebrafish CLCN7 Mammalian Cell His

    clcn7 involved in several pathways and played different roles in them. We selected most pathways clcn7 participated on our site, such as Ion channel transport, Stimuli-sensing channels, Transmembrane transport of small molecules, which may be useful for your reference. Also, other proteins which involved in the same pathway with clcn7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ion channel transport BEST3; CLIC2; ANO7; ASPH; TRPC6A; ATP1A1A.3; TRPC4; TPCN1; CLCN7; ATP1A1A.4
    Stimuli-sensing channels TRPC4APB; CLCN1A; SRI; ANO5; TRPM4C; ANO1; TRPM1B; CLCN4-2; CLIC2; TRPC5A
    Transmembrane transport of small molecules SLC6A19B; ADD3A; SLC4A1B; SLC15A1B; SLC22A17; ANO4; SLC9A3.1; ATP8B1; SLC8A2A; SLC17A1

    clcn7 has several biochemical functions, for example, ATP binding, antiporter activity, chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by clcn7 itself. We selected most functions clcn7 had, and list some proteins which have the same functions with clcn7. You can find most of the proteins on our site.

    Function Related Protein
    antiporter activity SLC9A3.1; SLC26A3.1; SLC9A5; SLC38A3; SLC7A6; SLC47A1; SLC35D2; SLC35D1A; SLC7A10; SLC8A1
    chloride channel activity CLIC4; CLCN5; CLCN1; CLCA2; GABRA1; CLCA1; SLC26A5; CFTR; GABRB2; GABRA3
    voltage-gated chloride channel activity CLCN4; CLCN6; ANO6; CLCN3; CLCNKA; CLCN5; CLCN4-2; CLCN2; CLCNK; CLCN7

    clcn7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with clcn7 here. Most of them are supplied by our site. Hope this information will be useful for your research of clcn7.

    CREB3; pi3p; Ktn1; SLC33A1; Kcnk1; Flot1; XRCC3; Atp2a2; ATP6AP2; Rab5c; Bmpr1a; RAB5C; TMEM63B; Nup98; SAMD1; C1qbp; FAM46A; Vps28; Cd2ap; Tmed2

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