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Official Full Name claudin 1
Background Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Synonyms CLDN1; claudin 1; claudin-1; ILVASC; SEMP1; senescence associated epithelial membrane protein 1; senescence-associated epithelial membrane protein 1; CLD1
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLDN1-11283H Recombinant Human CLDN1, GST-tagged E.coli GST
    Human CLDN1-1425H Recombinant Human CLDN1 Protein, GST-tagged Wheat Germ GST
    Human CLDN1-4298H Recombinant Human CLDN1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CLDN1-617H Recombinant Human CLDN1 Protein, His/GST-tagged E.coli His/GST
    Human CLDN1-7471HCL Recombinant Human CLDN1 293 Cell Lysate HEK293 N/A
    Mouse CLDN1-3521M Recombinant Mouse CLDN1 Protein Mammalian Cell His
    Mouse Cldn1-899M Recombinant Mouse Cldn1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CLDN1-1431R Recombinant Rat CLDN1 Protein Mammalian Cell His
    Rhesus Macaque CLDN1-890R Recombinant Rhesus monkey CLDN1 Protein, His-tagged Mammalian Cell His
    Chicken CLDN1-2173C Recombinant Chicken CLDN1 Mammalian Cell His
    Zebrafish CLDN1-9284Z Recombinant Zebrafish CLDN1 Mammalian Cell His

    cldn1 involved in several pathways and played different roles in them. We selected most pathways cldn1 participated on our site, such as Cell adhesion molecules (CAMs), Tight junction, Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with cldn1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell adhesion molecules (CAMs) MHC1UEA; CLDNB; CADM1B; NRXN1; CLDN15; SDC2; ALCAMA; ITGA6B; NRXN1A; PTPRC
    Tight junction CLDN20; CLDN11; ACTB1; CLDN14; SHROOM1; CLDNG; MYH6; MYH11A; CLDNB; MYLPFA
    Leukocyte transendothelial migration BCAR1; CLDN16; MAPK12; ITGAM; CYBA; AASS; MYL12A; RAC1; CLDN11; Itgam&Itgb2
    Pathogenic Escherichia coli infection NCK1; WAS; TUBB7P; WASL; ARPC5L; CTTN; YWHAZ; TUBA3E; ACTB; TUBB6
    Hepatitis C OAS1; MAPK3; CLDN15; STAT3; TLR3; PIK3R3; EIF2AK3; IFNA10; TP53; AKT1

    cldn1 has several biochemical functions, for example, identical protein binding, protein binding, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cldn1 itself. We selected most functions cldn1 had, and list some proteins which have the same functions with cldn1. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding GRASP; NUFIP1; ACADM; GRIK5; DRD4; SMAD1; PAFAH1B3; NOL3; DPP9; C14orf166
    protein binding PPP1R15A; MAPRE1; OCIAD1; DHX15; VTI1B; MC1R; TAF13; GRAMD3; EXO1; INHA
    structural molecule activity LOR; KRT96; KRT79; KRT13; CLTA; IFFO2; TUBA1B; PSMD13; EPB41L3A; COL18A1
    virus receptor activity PVRL2; SIVA1; CR1; DPP4; CLEC5A; SLC20A2; ITGB1; ACE2; SCARB1; CCR5

    cldn1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cldn1 here. Most of them are supplied by our site. Hope this information will be useful for your research of cldn1.


    Ghosn, J; Fouquet, B; et al. Claudin-1 Gene Variants and Susceptibility to Hepatitis C Infection in HIV-1 Infected Intravenous Drug Users (an ANRS Case-Control Study). JOURNAL OF MEDICAL VIROLOGY 87:619-624(2015).
    Xiao, F; Fofana, I; et al. Synergy of entry inhibitors with direct-acting antivirals uncovers novel combinations for prevention and treatment of hepatitis C. GUT 64:483-+(2015).

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