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COPS3

Official Full Name

COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
Overview

The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

COPS3; COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis); COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 3; COP9 signalosome complex subunit 3; CSN3; SGN3; signalosome subunit 3; COP9 complex subunit 3; JAB1-containing signalosome subunit 3;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

HEK293
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	COPS3-1702H	Recombinant Human COPS3 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	COPS3-7358HCL	Recombinant Human COPS3 293 Cell Lysate	HEK293	N/A		Inquiry
Human	COPS3-1955HF	Recombinant Full Length Human COPS3 Protein, GST-tagged	In Vitro Cell Free System	GST	423 amino acids	Inquiry
Mouse	COPS3-3780M	Recombinant Mouse COPS3 Protein	Mammalian Cell	His		Inquiry
Mouse	COPS3-1887M	Recombinant Mouse COPS3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	COPS3-1887M-B	Recombinant Mouse COPS3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	COPS3-1533R	Recombinant Rat COPS3 Protein	Mammalian Cell	His		Inquiry
Rat	COPS3-1190R	Recombinant Rat COPS3 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	COPS3-1190R-B	Recombinant Rat COPS3 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	COPS3-10083Z	Recombinant Zebrafish COPS3	Mammalian Cell	His		Inquiry
Chicken	COPS3-1314C	Recombinant Chicken COPS3	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
COPS3 Related Articles

COPS3 involved in several pathways and played different roles in them. We selected most pathways COPS3 participated on our site, such as DNA Damage Recognition in GG-NER, DNA Repair, Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with COPS3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
DNA Damage Recognition in GG-NER	PARP1;NFRKB;COPS7A;COPS6;INO80E;COPS4;DDB1;PARP2;COPS5
DNA Repair	ALKBH3;PARP1;TP53BP1;PPIE;ASCC1;BARD1;GEN1;INO80E;PIAS3
Formation of TC-NER Pre-Incision Complex	ERCC8;KIAA1530;COPS5;TCEA1;ZNF830;COPS4;COPS2;ZFP830;COPS3
Global Genome Nucleotide Excision Repair (GG-NER)	TFPT;MCRS1;ACTR5;INO80C;COPS8;INO80E;PIAS3;PARP2;YY1
Nucleotide Excision Repair	COPS7B;GTF2H1;ZFP830;ERCC2;POLD2;GTF2H2C;INO80B;RFC4;RAD23A
TNF-alpha/NF-kB Signaling Pathway	PDCD2;TNIP1;UNC5CL;DDX3X;AKAP8;DAP;G3BP2;COPS3;ZFAND5
Transcription-Coupled Nucleotide Excision Repair (TC-NER)	COPS7A;GPS1;ERCC8;PPIE;COPS3;COPS2;COPS4;COPS6;ZNF830

COPS3 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COPS3 itself. We selected most functions COPS3 had, and list some proteins which have the same functions with COPS3. You can find most of the proteins on our site.

Function	Related Protein
protein binding	KRTAP12-2;ODAM;RGS8;CCDC151;CNST;MPL;HIST1H1A;APOO;BCL6

COPS3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COPS3 here. Most of them are supplied by our site. Hope this information will be useful for your research of COPS3.

COPS5; COPS6; COPS7A

McMichael, G; Girirajan, S; et al. Rare copy number variation in cerebral palsy. EUROPEAN JOURNAL OF HUMAN GENETICS 22:40-45(2014).

Goossens, DJ; Brazier-Hollins, S; et al. Magnetic structure and glassiness in Fe0.5Ni0.5PS3. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 334:82-86(2013).