COQ3 Protein


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Official Full Name coenzyme Q3 homolog, methyltransferase
Background Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both;eukaryotes and prokaryotes (Jonassen and Clarke, 2000 (PubMed 10777520)). This lipid consists of a hydrophobic;isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to;anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the;respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic;pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic;acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene;product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl;phenol.
Synonyms COQ3; coenzyme Q3 homolog, methyltransferase (S. cerevisiae); coenzyme Q3 homolog, methyltransferase (yeast); hexaprenyldihydroxybenzoate methyltransferase, mitochondrial; bA9819.1; polyprenyldihydroxybenzoate methyltransferase; DHHB-MT; DHHB-MTase; DHHB
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COQ3-1715H Recombinant Human COQ3 Protein, GST-tagged Wheat Germ GST
    Rat COQ3-1538R Recombinant Rat COQ3 Protein Mammalian Cell His
    Zebrafish COQ3-733Z Recombinant Zebrafish COQ3 Mammalian Cell His
    Human COQ3-7348HCL Recombinant Human COQ3 293 Cell Lysate HEK293 N/A
    Human COQ3-1974HF Recombinant Full Length Human COQ3 Protein, GST-tagged In Vitro Cell Free System GST
    Human COQ3-5716H Recombinant Human COQ3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Coq3-2269M Recombinant Mouse Coq3 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    COQ3 involved in several pathways and played different roles in them. We selected most pathways COQ3 participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with COQ3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquinone and other terpenoid-quinone biosynthesis HPD; HPDA; COQ6; VKORC1L1; COQ2; GGCX; COQ5; TAT; COQ3; HPDB

    COQ3 has several biochemical functions, for example, 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity, 3-demethylubiquinone-9 3-O-methyltransferase activity, O-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COQ3 itself. We selected most functions COQ3 had, and list some proteins which have the same functions with COQ3. You can find most of the proteins on our site.

    Function Related Protein
    2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity COQ3; PRDM12; PRDM11; PRDM13; RNMTL1B; METTL21A; PRMT8B; TRMT10B; NDUFAF5; METTL23
    3-demethylubiquinone-9 3-O-methyltransferase activity COQ3
    O-methyltransferase activity PRDM12; ASMT; DIMT1; NDUFAF5; METTL23; ASMTL; ASMT2; TRMT10C; COQ3; COMTD1
    hexaprenyldihydroxybenzoate methyltransferase activity COQ3

    COQ3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COQ3 here. Most of them are supplied by our site. Hope this information will be useful for your research of COQ3.


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