• Official Full Name

    COX18 cytochrome c oxidase assembly homolog (S. cerevisiae)

  • Overview

    COX18 encodes a cytochrome c oxidase (COX)-assembly protein. The S. cerevisiae Cox18 protein catalyzes the insertion of;the Cox2 (MTCO2; MIM 516040) C-terminal tail into the mitochondrial inner membrane, an intermediate step in the;assembly of complex IV of the mitochondrial respiratory chain (Sacconi et al., 2005 (PubMed 16212937)).
  • Synonyms

    COX18; COX18 cytochrome c oxidase assembly homolog (S. cerevisiae); mitochondrial inner membrane protein COX18; FLJ38991; COII; COX2; COX2_HUMAN; COXII; Cytochrome c oxidase II; Cytochrome c oxidase polypeptide II; Cytochrome c oxidase subunit 2; MS405; MS419; MT CO2; MT-CO2; MTCO2; Cox18Hs1 protein; Cox18Hs2 protein; Cox18Hs3 protein; OTTHUMP00000160366; OTTHUMP00000219030; mitochondrial COX18; cytochrome c oxidase assembly protein 18; COX18HS;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COX18-11489H Recombinant Human COX18, GST-tagged E.coli GST 187-333a.a.
Human COX18-1740H Recombinant Human COX18 Protein, GST-tagged Wheat Germ GST
Human COX18-2001HF Recombinant Full Length Human COX18 Protein, GST-tagged In Vitro Cell Free System GST 333 amino acids
Mouse COX18-3811M Recombinant Mouse COX18 Protein Mammalian Cell His
Mouse COX18-1912M-B Recombinant Mouse COX18 Protein Pre-coupled Magnetic Beads HEK293
Mouse COX18-1912M Recombinant Mouse COX18 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mus musculus (Mouse) RFL1417MF Recombinant Full Length Mouse Mitochondrial Inner Membrane Protein Cox18(Cox18) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (64-331)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

COX18 involved in several pathways and played different roles in them. We selected most pathways COX18 participated on our site, such as Gene Expression, Generic Transcription Pathway, Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Generic Transcription PathwayZNF668;ZNF311;SESN3;ZIK1;ZNF202;ZNF398;ZNF726;ZNF223;ZNF354B
Respiratory electron transportTIMMDC1;NDUFAF6;NDUFAF4;COX16;COX18;LRPPRC;C20orf7;NDUFAF5;NDUFAF2
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.ATP5L;C2orf56;NDUFAF7;FAM36A;UCP2;SURF1;NDUFAF5;ETFB;NDUFAF6
TP53 Regulates Metabolic GenesLRPPRC;COX18;TACO1;PRDX2;SESN3;COX16;SURF1;COX14;SCO1
The citric acid (TCA) cycle and respiratory electron transportNDUFAF3;COX14;ADHFE1;PDP1;FAM36A;UCP2;ATP5S;ETFA;D2HGDH
Transcriptional Regulation by TP53COX16;COX18;FAM36A;TACO1;PRDX2;SESN3;COX14

COX18 has several biochemical functions, for example, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COX18 itself. We selected most functions COX18 had, and list some proteins which have the same functions with COX18. You can find most of the proteins on our site.

Function Related Protein
protein transporter activityARFGAP3;EIF4ENIF1;DSCR3;COX18;IPO13;RAMP2;AP1S1;CCT6B;L7RN6

COX18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX18 here. Most of them are supplied by our site. Hope this information will be useful for your research of COX18.

Research Area

Related articles

Vandell, AG; McDonough, CW; et al. Hydrochlorothiazide-induced hyperuricaemia in the pharmacogenomic evaluation of antihypertensive responses study. JOURNAL OF INTERNAL MEDICINE 276:486-497(2014).
Goncalves, VF; Zai, CC; et al. A Hypothesis-Driven Association Study of 28 Nuclear-Encoded Mitochondrial Genes with Antipsychotic-Induced Weight Gain in Schizophrenia. NEUROPSYCHOPHARMACOLOGY 39:1347-1354(2014).
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