COX5B
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Official Full Name
cytochrome c oxidase subunit Vb -
Overview
Cytochrome C oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit Vb of the human mitochondrial respiratory chain enzyme. -
Synonyms
COX5B;cytochrome c oxidase subunit Vb;cytochrome c oxidase subunit 5B, mitochondrial;mitochondrial;COX 5B;COX5B_HUMAN;COXVB;Cytochrome c oxidase polypeptide Vb;Cytochrome c oxidase polypeptide VB mitochondrial;Cytochrome c oxidase subunit 5B;Cytochrome c oxidase subunit 5B mitochondrial;OTTHUMP00000161109;cytochrome c oxidase polypeptide VB, mitochondrial
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
COX5B involved in several pathways and played different roles in them. We selected most pathways COX5B participated on our site, such as Alzheimers disease,Cardiac muscle contraction,Electron Transport Chain, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Electron Transport Chain | UCP3,SURF1,COX7A2,ATP5H,COX6B1,ATP5S,COX15,COX6C,COX17,UCP2 |
| Generic Transcription Pathway | TBX5,NR2C2AP,ZNF559,ZNF584,ZNF436,ZNF620,ZNF493,KRBOX4,NR5A1A,ZFP2 |
| Gene Expression | ZNF658,ZNF786,ZNF584,PTBP1,TSN,IGF2BP1,NELFE,ZIM2,NR4A2A,ZNF664 |
| Metabolic pathways | TM7SF2,MBOAT2,MCCC1,PANK1B,AMY2B,PIGP,UAP1,NDUFS3,SGMS1,AOX4 |
| Metabolism | NAT2,ARL2,SLC25A32A,CYP2W1,PLB1,CYP2AD3,COX18,DDAH1,GGT6,OSBP |
| Cardiac muscle contraction | CACNA2D3,CACNA2D2,CACNA2D1A,ATP1A1,COX5AA,ATP1B2B,ATP1A1B,COX8A,UQCRB,ATP1B1B |
| Alzheimers disease | CHP,APBB1,MAPT,ATP5B,UQCRC2,TNF,LPL,ITPR1,PLCB3,ITPR2 |
| Huntingtons disease | NDUFB6,COX7C,NDUFB8,CYCS,GRM5,GRIN2B,PPARG,POLR2C,COX7A2,UQCRFS1 |
Protein Function
COX5B has several biochemical functions, for example, cytochrome-c oxidase activity,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COX5B itself. We selected most functions COX5B had, and list some proteins which have the same functions with COX5B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | CBFA2T3,ZNF843,MAP3K13,SP5,HEPHL1A,JAZF1B,SCNM1-PS,ATP2C1,ZBTB8B,ZBED6 |
| protein binding | SMN1,DPCD,FXYD7,PDGFB,ATG3,SYTL2,FAM60A,TECPR2,ERRFI1,UIMC1 |
| cytochrome-c oxidase activity | COX4I1,COA6,COX7B,COX7A2A,COX6A1,COX8C,COX7A1,COX6A2,COX11,COX6B1 |
Interacting Protein
COX5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX5B here. Most of them are supplied by our site. Hope this information will be useful for your research of COX5B.
TRIM23;CCDC36;BHLHE40;KRT15;CDR2;TRAF1
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