Recombinant Human cytochrome c oxidase subunit Vb, His-tagged

Cat.No. : COX5B-202H
Product Overview : COX5B, 32-129aa, Human, His tag, E.coli
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  • Gene Information
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Description : Cytochrome c oxidase subunit 5B, also known as COX5B, is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. Two isoforms of COX5 exist, COX5a and COX5b. When oxygen levels within the cell are high, transcription of COX5A (the aerobic isoform) is up-regulated as the rate of cellular respiration increases. Conversely, when oxygen levels are low, COX5B (the hypoxic isoform) transcription increases and functions to maximize the turnover rate of the COX apoenzyme. Recombinant human COX5B protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
Source : E.coli
Species : Human
Tag : His-tag
Form : Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 20% glycerol, 1mM DTT
Molecular Mass : 13 kDa (121aa), confirmed by MALDI-TOF(Molecular size on SDS-PAGE will appear higher)
Purity : >95% by SDS - PAGE
Storage : Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
Concentration : 0.5mg/ml (determined by Bradford assay)
Gene Name : COX5B cytochrome c oxidase subunit Vb [ Homo sapiens ]
Official Symbol : COX5B
Synonyms : COX5B; cytochrome c oxidase subunit Vb; cytochrome c oxidase subunit 5B, mitochondrial; cytochrome c oxidase polypeptide VB, mitochondrial; COXVB;
Gene ID : 1329
mRNA Refseq : NM_001862
Protein Refseq : NP_001853
MIM : 123866
UniProt ID : P10606
Chromosome Location : 2q11.2
Pathway : Alzheimers disease, organism-specific biosystem; Alzheimers disease, conserved biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; Cardiac muscle contraction, organism-specific biosystem; Cardiac muscle contraction, conserved biosystem; Cytochrome c oxidase, organism-specific biosystem; Cytochrome c oxidase, conserved biosystem;
Function : cytochrome-c oxidase activity; metal ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.


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