COX7B
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Official Full Name
cytochrome c oxidase subunit VIIb -
Overview
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIb, which is highly similar to bovine COX VIIb protein and is found in all tissues. This gene may have several pseudogenes on chromosomes 1, 2, 20 and 22. -
Synonyms
COX7B;cytochrome c oxidase subunit VIIb;cytochrome c oxidase subunit 7B, mitochondrial;mitochondrial;COX7B_HUMAN;Cytochrome c oxidase chain VIIb;Cytochrome c oxidase polypeptide VIIb;Cytochrome c oxidase subunit 7B;Cytochrome c oxidase subunit 7B mitochondrial;cytochrome-c oxidase chain VIIb
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- Rhesus macaque
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- GST
- Avi
- Fc
Involved Pathway
COX7B involved in several pathways and played different roles in them. We selected most pathways COX7B participated on our site, such as Oxidative phosphorylation,Metabolic pathways,Cardiac muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COX7B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Non-alcoholic fatty liver disease (NAFLD) | Fasl,KCNA3,NDUFA2,NDUFA8,NDUFB11,INSR,NDUFB1,AKT2,PIK3R1,NDUFS2 |
| Cardiac muscle contraction | TNNC1,CACNG2A,TPM4B,CACNA1C,COX7A2A,VMHCL,TNNI3,UQCRFS1,UQCR11,ATP1A4 |
| Metabolic pathways | URAH,Atp5g2,NT5C2B,FUT3,PRODH2,PIGYL,SHMT1,MAT2A,SQLE,UGDH |
| Huntingtons disease | CYCS,NDUFA6,mt-Atp8,TBPL1,NDUFS5,SDHA,TBP,NDUFA13,POLR2C,PLCB3 |
| Oxidative phosphorylation | PPA2,NDUFS8,NDUFV2,ATP4A,mt-Atp8,MT-ND1,ATP6V1G3,UQCR10,SDHD,ATP6V0E1 |
| Alzheimers disease | CYCS,NDUFC2-KCTD14,ATP5H,APBB1,UQCR11,COX4I2,ATF6,NAE1,EIF2AK3,SNCA |
| Parkinsons disease | UBE2L3,UQCRB,COX7A2L,NDUFA7,NDUFS6,ATP5G3,UBE1Y1,NDUFB6,NDUFA5,COX5A |
Protein Function
COX7B has several biochemical functions, for example, cytochrome-c oxidase activity,molecular_function. Some of the functions are cooperated with other proteins, some of the functions could acted by COX7B itself. We selected most functions COX7B had, and list some proteins which have the same functions with COX7B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| molecular_function | FADS6,TMEM57B,GM4179,DCUN1D4,PEX11C,ANKRD10B,DCAF12L1,GIPC2,TMCC2,RGS7BPA |
| cytochrome-c oxidase activity | COX7A1,COX11,COX6A2,COX6C,COX7A2A,COX8A,CYB5A,COA6,COX7A2,COX7C |
Interacting Protein
COX7B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COX7B here. Most of them are supplied by our site. Hope this information will be useful for your research of COX7B.
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References
- Nijtmans, LGJ; Taanman, JW; et al. Assembly of cytochrome-c oxidase in cultured human cells. EUROPEAN JOURNAL OF BIOCHEMISTRY 254:389-394(1998).
- Arnold, S; Lee, I; et al. The subunit structure of cytochrome-c oxidase from tuna heart and liver. EUROPEAN JOURNAL OF BIOCHEMISTRY 248:99-103(1997).
