Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

CPSF3

  • Official Full Name

    cleavage and polyadenylation specific factor 3, 73kDa

  • Overview

    Most eukaryotic mRNA precursors (pre-mRNAs) undergo extensive maturational processing, including cleavage and;polyadenylation at the 3-prime end. CPSF3 encodes the 73-kD subunit of the cleavage and polyadenylation specificity;factor (CPSF) and is the pre-mRNA 3-prime-end-processing endonuclease (Mandel et al., 2006 (PubMed;17128255)).
  • Synonyms

    CPSF3; cleavage and polyadenylation specific factor 3, 73kDa; cleavage and polyadenylation specific factor 3, 73kD subunit; cleavage and polyadenylation specificity factor subunit 3; CPSF 73; CPSF73; YSH1; Cleavage and polyadenylation specificity factor 73 kDa subunit; CPSF; OTTHUMP00000115483; OTTHUMP00000214089; CPSF 73 kDa subunit; mRNA 3-end-processing endonuclease CPSF-73; cleavage and polyadenylation specificity factor 3; cleavage and polyadenylation specificity facto; CPSF-73;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CPSF3-11537H Recombinant Human CPSF3, GST-tagged E.coli GST C-term-348a.a.
Human CPSF3-1812H Recombinant Human CPSF3 Protein, GST-tagged Wheat Germ GST
Human CPSF3-7304HCL Recombinant Human CPSF3 293 Cell Lysate HEK293 N/A
Human CPSF3-1458H Recombinant Human CPSF3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CPSF3-655H Recombinant Human CPSF3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CPSF3-2154HF Recombinant Full Length Human CPSF3 Protein, GST-tagged In Vitro Cell Free System GST 684 amino acids
Human CPSF3-655H-B Recombinant Human CPSF3 Protein Pre-coupled Magnetic Beads HEK293
Human CPSF3-699HFL Recombinant Full Length Human CPSF3 Protein, C-Flag-tagged Mammalian cells Flag
Zebrafish CPSF3-1127Z Recombinant Zebrafish CPSF3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CPSF3 Related Articles

CPSF3 involved in several pathways and played different roles in them. We selected most pathways CPSF3 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPSF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
mRNA surveillance pathwaySMG7;SMG6;PELO;PPP1CB;PPP2R3C;PABPC4;PABPC1A;PPP2R2CA;MSI1

CPSF3 has several biochemical functions, for example, 5-3 exonuclease activity, RNA binding, endoribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CPSF3 itself. We selected most functions CPSF3 had, and list some proteins which have the same functions with CPSF3. You can find most of the proteins on our site.

Function Related Protein
5-3 exonuclease activityCPSF3;EXO1;DCLRE1C;DOM3Z;POLN;FAN1;FEN1;DXO;XRN2
RNA bindingDNMT1;RBM4.1;NABP1;CNOT8;SCAF8;ILF3;RBMS3;SRSF1B;WT1
endoribonuclease activityENDOU;RNASEKA;NOB1;TSN;RNASET2;RNASEKB;AGO2;RCL1;DICER1
metal ion bindingZNF295;TGM5;TRIM35-27;GALNS;BCL11AA;CNOT4B;KLF7A;TGFBR2;ITGA7
protein bindingL3MBTL4;TERF1;SELP;DHX15;TNFAIP3;STX12;KCNA2;LAMTOR1;RUNX2

CPSF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPSF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPSF3.

SYMPK; CPSF2; WWOX; GSTK1; HSPB1; ssdna_dtdg; P4HA2; KIF21B; CPSF4; NPM1; P4HB

Gotoh, M; Ichikawa, H; et al. Comprehensive Exploration of Novel Chimeric Transcripts in Clear Cell Renal Cell Carcinomas Using Whole Transcriptome Analysis. GENES CHROMOSOMES & CANCER 53:1018-1032(2014).
Li, CL; Wang, XL; et al. Microarray analysis revealed that immunity-associated genes are primarily regulated by roxarsone in promoting broiler chicken (Gallus gallus domesticus) growth. POULTRY SCIENCE 91:3184-3190(2012).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is CPSF3 protein related to RNA metabolism disorders? 06/10/2022

Mutations in CPSF3 have been associated with RNA metabolism disorders, leading to dysregulation of gene expression.

What are the potential therapeutic implications of targeting CPSF3 in cancer? 05/01/2022

Inhibiting CPSF3 function may be a potential therapeutic strategy for treating certain types of cancer.

Can CPSF3 protein be targeted for drug development? 04/25/2022

Yes, CPSF3 has been identified as a potential target for drug development in cancer therapy.

How is CPSF3 protein involved in neurodevelopmental disorders? 02/08/2018

CPSF3 mutations have been linked to neurodevelopmental disorders such as intellectual disability and autism spectrum disorders.

Are there any diagnostic applications of CPSF3 protein in cancer? 05/25/2017

CPSF3 expression levels may be used as a biomarker for certain types of cancer and as a potential diagnostic tool.

Customer Reviews (3)

Write a review
Reviews
08/29/2022

    Beyond its superb performance in Western blotting, the CPSF3 protein has also proven invaluable in protein electron microscopy structure analysis.

    03/28/2022

      the CPSF3 protein comes highly recommended for its exceptional performance in Western blot analysis and its utility in protein electron microscopy structure analysis.

      10/04/2020

        Its versatility and reliability make it an excellent choice for researchers seeking to delve deeper into the mechanisms and functions of the CPSF3 protein.

        Ask a Question for All CPSF3 Products

        Required fields are marked with *

        My Review for All CPSF3 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends