CPSF3
-
Official Full Name
cleavage and polyadenylation specific factor 3, 73kDa
-
Overview
Most eukaryotic mRNA precursors (pre-mRNAs) undergo extensive maturational processing, including cleavage and;polyadenylation at the 3-prime end. CPSF3 encodes the 73-kD subunit of the cleavage and polyadenylation specificity;factor (CPSF) and is the pre-mRNA 3-prime-end-processing endonuclease (Mandel et al., 2006 (PubMed;17128255)). -
Synonyms
CPSF3; cleavage and polyadenylation specific factor 3, 73kDa; cleavage and polyadenylation specific factor 3, 73kD subunit; cleavage and polyadenylation specificity factor subunit 3; CPSF 73; CPSF73; YSH1; Cleavage and polyadenylation specificity factor 73 kDa subunit; CPSF; OTTHUMP00000115483; OTTHUMP00000214089; CPSF 73 kDa subunit; mRNA 3-end-processing endonuclease CPSF-73; cleavage and polyadenylation specificity factor 3; cleavage and polyadenylation specificity facto; CPSF-73;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CPSF3-11537H | Recombinant Human CPSF3, GST-tagged | E.coli | GST | C-term-348a.a. | |
Human | CPSF3-1812H | Recombinant Human CPSF3 Protein, GST-tagged | Wheat Germ | GST | ||
Human | CPSF3-7304HCL | Recombinant Human CPSF3 293 Cell Lysate | HEK293 | N/A | ||
Human | CPSF3-1458H | Recombinant Human CPSF3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | CPSF3-655H | Recombinant Human CPSF3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | CPSF3-2154HF | Recombinant Full Length Human CPSF3 Protein, GST-tagged | In Vitro Cell Free System | GST | 684 amino acids | |
Human | CPSF3-655H-B | Recombinant Human CPSF3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | CPSF3-699HFL | Recombinant Full Length Human CPSF3 Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Zebrafish | CPSF3-1127Z | Recombinant Zebrafish CPSF3 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- CPSF3 Related Articles
CPSF3 involved in several pathways and played different roles in them. We selected most pathways CPSF3 participated on our site, such as mRNA surveillance pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CPSF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
mRNA surveillance pathway | SMG7;SMG6;PELO;PPP1CB;PPP2R3C;PABPC4;PABPC1A;PPP2R2CA;MSI1 |
CPSF3 has several biochemical functions, for example, 5-3 exonuclease activity, RNA binding, endoribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CPSF3 itself. We selected most functions CPSF3 had, and list some proteins which have the same functions with CPSF3. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
5-3 exonuclease activity | CPSF3;EXO1;DCLRE1C;DOM3Z;POLN;FAN1;FEN1;DXO;XRN2 |
RNA binding | DNMT1;RBM4.1;NABP1;CNOT8;SCAF8;ILF3;RBMS3;SRSF1B;WT1 |
endoribonuclease activity | ENDOU;RNASEKA;NOB1;TSN;RNASET2;RNASEKB;AGO2;RCL1;DICER1 |
metal ion binding | ZNF295;TGM5;TRIM35-27;GALNS;BCL11AA;CNOT4B;KLF7A;TGFBR2;ITGA7 |
protein binding | L3MBTL4;TERF1;SELP;DHX15;TNFAIP3;STX12;KCNA2;LAMTOR1;RUNX2 |
CPSF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CPSF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CPSF3.
SYMPK; CPSF2; WWOX; GSTK1; HSPB1; ssdna_dtdg; P4HA2; KIF21B; CPSF4; NPM1; P4HB
- Q&As
- Reviews
Q&As (5)
Ask a questionMutations in CPSF3 have been associated with RNA metabolism disorders, leading to dysregulation of gene expression.
Inhibiting CPSF3 function may be a potential therapeutic strategy for treating certain types of cancer.
Yes, CPSF3 has been identified as a potential target for drug development in cancer therapy.
CPSF3 mutations have been linked to neurodevelopmental disorders such as intellectual disability and autism spectrum disorders.
CPSF3 expression levels may be used as a biomarker for certain types of cancer and as a potential diagnostic tool.
Customer Reviews (3)
Write a reviewBeyond its superb performance in Western blotting, the CPSF3 protein has also proven invaluable in protein electron microscopy structure analysis.
the CPSF3 protein comes highly recommended for its exceptional performance in Western blot analysis and its utility in protein electron microscopy structure analysis.
Its versatility and reliability make it an excellent choice for researchers seeking to delve deeper into the mechanisms and functions of the CPSF3 protein.
Ask a Question for All CPSF3 Products
Required fields are marked with *
My Review for All CPSF3 Products
Required fields are marked with *