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Official Full Name cAMP responsive element binding protein 3
Background This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.
Synonyms CREB3; cAMP responsive element binding protein 3; cAMP responsive element binding protein 3 (luman); cyclic AMP-responsive element-binding protein 3; Luman; LZIP; CREB-3; basic leucine zipper protein; transcription factor LZIP-alpha; cAMP-responsive eleme
    • Species :
    • Human
    • Rhesus Macaque
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CREB3-1842H Recombinant Human CREB3 Protein, GST-tagged Wheat Germ GST
    Human CREB3-396HCL Recombinant Human CREB3 cell lysate N/A
    Rhesus Macaque CREB3-1020R Recombinant Rhesus monkey CREB3 Protein, His-tagged Mammalian Cell His

    creb3 involved in several pathways and played different roles in them. We selected most pathways creb3 participated on our site, such as AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholism, which may be useful for your reference. Also, other proteins which involved in the same pathway with creb3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AMPK signaling pathway PFKL; PPP2R5D; PPP2R3A; STRADB; CAMKK1; RAB11B; SCD; RPS6KB1; IRS4; PIK3CA
    Adrenergic signaling in cardiomyocytes PIK3R3; PPP2CB; CACNA1C; CACNA2D1A; ATP2B1A; AGTR1; PRKACA; GNAI1; TPMA; CACNG8
    Alcoholism GNAO1; HIST2H3C; NPY; GNB5; ATF6B; HIST1H2BO; GNB2; HIST2H3C2; H3F3B; HIST4H4
    Aldosterone synthesis and secretion NETO2; CREB3L3; ADCY1; ADCY9; PRKCE; ITPR1; Adcy4; PRKACB; HSD3B2; CAMK2G
    Amphetamine addiction GRIN3B; CALM3; CREB3L3; PPP1CC; GNAS; PRKACA; ATF6B; GRIA3; PRKACG; DRD1A
    Cholinergic synapse PIK3CG; PIK3R2; GNGT2; PRKCA; JAK2; ITPR1; KCNJ12; AKR1C1; ITPR3; PIK3CB
    Cocaine addiction DLG4; GNAI3; MAOA; PDYN; DRD2; PRKACA; BDNF; GRIN3A; TH; PRKACB
    Dopaminergic synapse KCNJ5; DRD5; GNG12; PPP3CC; DRD4; MAPK13; DRD1A; PLCB1; PRKCB; PPP2R1A

    creb3 has several biochemical functions, for example, CCR1 chemokine receptor binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by creb3 itself. We selected most functions creb3 had, and list some proteins which have the same functions with creb3. You can find most of the proteins on our site.

    Function Related Protein
    CCR1 chemokine receptor binding CCL5; CREB3; CCL4; CCL23; CCL3; CCL7
    DNA binding TBL1Y; PGR; CDT1; ALX4; SIX1; PRRX1A; EGR3; CDK5R2; HIST1H2AK; ELK4
    RNA polymerase II core promoter proximal region sequence-specific DNA binding SNAI3; ZNF562; NEUROD6; ZSCAN21; TFE3; E2F8; MAFB; NFE2L3; NFIB; FOSL1
    RNA polymerase II regulatory region sequence-specific DNA binding ZNF79; EOMES; NME2; AIRE; SP3; CUX2; ATF4B1; SUV39H1; NEUROD2; ZBTB16A
    cAMP response element binding JUN; CREB3L3; HMGA2; CREB1; CREB3L4; ATF2; ATF6B; CREB3L3L; CREB3L3A; CREB3L2
    cAMP response element binding protein binding DAPK3; CREM; CRTC2; CRTC3; CRTC1; DDIT3; ATF2; KCNA3; CRTC1A; CREB3
    chromatin binding UBTFL; ELK4; SVEP1; CDC45; NFKB1; TTC5; SP100; SALL1; GPR30; HDGFRP2
    protein binding FRMD6; TMEM119; NEUROD1; PCM1; USP17L2; INCENP; ARL14; CXCL9; PRELID1; NDNL2
    protein dimerization activity MAX; ASCL2; POU2F3; ARNTL1A; TFAP2C; NEUROG1; POLR1C; AHRRA; SREBF1; SOHLH1
    protein homodimerization activity TESCA; ACAT1; S100A11; SP1; GPD1C; ABCG2; GOT2; CHMP4C; TERF1; TNNC1
    transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding BATF2; JDP2; ARNTL2; BATF; CLOCK; FOS; SREBF1; RBPJL; ATF3; ARNTL
    transcription factor activity, sequence-specific DNA binding HOXB6B; IKZF4; AATF; PAX7; ZIC1; ZNF711; GCM1; ZSCAN4F; POU4F1; HOXB6
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ONECUTL; SOX1; NR5A2; NR1H2; POU4F3; BCL11B; CTCFL; TFAP2E; MEIS3; SIX1

    creb3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with creb3 here. Most of them are supplied by our site. Hope this information will be useful for your research of creb3.


    Felizola, SJA; Nakamura, Y; et al. Activating Transcription Factor 3 (ATF3) in the Human Adrenal Cortex: Its Possible Involvement in Aldosterone Biosynthesis. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 234:249-254(2014).
    Kawarabayashi, Y; Hai, L; et al. Critical Role of TRPC1-Mediated Ca2+ Entry in Decidualization of Human Endometrial Stromal Cells. MOLECULAR ENDOCRINOLOGY 26:846-858(2012).

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