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CREB3

  • Official Full Name

    cAMP responsive element binding protein 3

  • Overview

    This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.
  • Synonyms

    CREB3; cAMP responsive element binding protein 3; cAMP responsive element binding protein 3 (luman); cyclic AMP-responsive element-binding protein 3; Luman; LZIP; CREB-3; basic leucine zipper protein; transcription factor LZIP-alpha; cAMP-responsive eleme;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Rhesus Macaque
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CREB3-1842H Recombinant Human CREB3 Protein, GST-tagged Wheat Germ GST
Human CREB3-396HCL Recombinant Human CREB3 cell lysate N/A
Human CREB3-2261HF Recombinant Full Length Human CREB3 Protein, GST-tagged In Vitro Cell Free System GST 371 amino acids
Homo sapiens (Human) RFL11908HF Recombinant Full Length Human Cyclic Amp-Responsive Element-Binding Protein 3(Creb3) Protein, His-Tagged E.coli expression system His Full Length (1-395)
Rhesus Macaque CREB3-1020R Recombinant Rhesus monkey CREB3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CREB3-845R Recombinant Rhesus Macaque CREB3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CREB3-845R-B Recombinant Rhesus Macaque CREB3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CREB3 Related Articles
  • CREB3 Related Signal Pathway

CREB3 involved in several pathways and played different roles in them. We selected most pathways CREB3 participated on our site, such as AMPK signaling pathway, Adrenergic signaling in cardiomyocytes, Alcoholism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CREB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AMPK signaling pathwayPIK3CD;G6PC2;PDPK1;CREB5;IGF1;G6PC3;FOXO1;CFTR;MTOR
Adrenergic signaling in cardiomyocytesCREB3L4;CACNA2D1A;ADRB2A;CREB3L3A;TNNC1A;AGTR1;ATP2B2;ATF4B1;ATP1B2
AlcoholismH2AFY;HIST1H2AA;HIST1H2BO;HDAC1;GNAO1;CALML3;H2AFJ;HIST3H3;HRAS
Aldosterone synthesis and secretionPRKACG;ORAI1;CREB3;CALML5;MC2R;ADCY9;HSD3B6;CYP11A1;ATF1
Cholinergic synapseGNGT1;KCNJ12;CREB5;ITPR1;AKT1;KCNJ6;PIK3CA;GNG12;MAP2K1
Cocaine addictionGRIA2;RGS9;MAOB;GNAI3;DRD1;RELA;ATF6B;GRIN2B;GPSM1
Dopaminergic synapsePPP1CC;GRIA4;GNAI2;ARNTL;AKT1;GNG11;GNAI1;ARRB2;GNB3

CREB3 has several biochemical functions, for example, CCR1 chemokine receptor binding, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CREB3 itself. We selected most functions CREB3 had, and list some proteins which have the same functions with CREB3. You can find most of the proteins on our site.

Function Related Protein
CCR1 chemokine receptor bindingCCL4;CCL5;CCL23;CCL7;CREB3;CCL3
DNA bindingTERT;TBL1XR1;ANG;DICER1;TFAP2B;HIST2H2BE;HES3;SRFB;HOXA10B
RNA polymerase II core promoter proximal region sequence-specific DNA bindingFUBP3;MITF;KLF5;TBX3;SMAD4;CTCF;IFI203;KCNA3;NFIC
RNA polymerase II regulatory region sequence-specific DNA bindingFOXF1;IKZF5;ZBTB12.2;MNT;NKX2-1;HOXD9;GLIS1;HES6;TAL2
cAMP response element bindingATF6B;ATF2;JUN;CREB3L2;HMGA2;CREB3;CREB3L3L;ATF6;E4F1
cAMP response element binding protein bindingDAPK3;CREB3;CRTC3;ATF2;CRTC1;KCNA3;CREM;CRTC2;DDIT3
chromatin bindingENY2;MCMBP;GM606;FOSL2;PHF21B;MEF2C;MEOX1;MEIOB;TMPOA
protein bindingKRTAP4-11;CCT6A;GSK3B;USP36;STX18;IRF5;GYS1;SOS1;FNTB
protein dimerization activityARNTL2;PIP4K2AA;HER15.1;MYCB;POLR1C;DBI;ATOH7;PEX3;ASCL3
protein homodimerization activitySMAD4;NR2C1;ALX1;DLK2;LHPP;TMEM173;MSH2;FIGF;TSC2
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific bindingSFPI1;MSX1;BATF2;FOSL1A;RBPJL;FOSL1;JDP2;CREB3;IRF7
transcription factor activity, sequence-specific DNA bindingGABPB1;IKZF2;FLI1A;HOMEZB;JUN;ZNF134;DLX6;FOXN2B;PRRXL1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGATA2;ONECUT1;NFIC;KLF4;ZSCAN21;NKX2-8;HNF4A;NR4A2;PBX1

CREB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CREB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CREB3.

HCFC1; STX8; JUN; DDIT3; NFIL3; CREB3L3; BATF3; CREBZF; CREB3L4; 10431

Felizola, SJA; Nakamura, Y; et al. Activating Transcription Factor 3 (ATF3) in the Human Adrenal Cortex: Its Possible Involvement in Aldosterone Biosynthesis. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 234:249-254(2014).
Kawarabayashi, Y; Hai, L; et al. Critical Role of TRPC1-Mediated Ca2+ Entry in Decidualization of Human Endometrial Stromal Cells. MOLECULAR ENDOCRINOLOGY 26:846-858(2012).
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