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CSNK1A1

  • Official Full Name

    casein kinase 1, alpha 1

  • Overview

    Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.
  • Synonyms

    CSNK1A1; casein kinase 1, alpha 1; casein kinase I isoform alpha; CK1; CK1a; CK1alpha; CKIa; CKIalpha; clock regulator kinase; CKI-alpha; down-regulated in lung cancer; HLCDGP1; PRO2975;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Pig
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • Baculovirus-Insect cells
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • Wheat Germ
  • C
  • His
  • Flag,His
  • GST
  • GST|His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CSNK1A1-58HFL Active Recombinant Full Length Human CSNK1A1 Protein, N-Flag,N-His-tagged Sf21 Flag,His Full Length
Human CSNK1A1-964H Active Recombinant Human CSNK1A1 protein, GST-tagged Insect Cells GST Met1-Phe337
Human CSNK1A1-677H Recombinant Human Casein Kinase 1, Alpha 1, GST-tagged Insect Cell GST
Human CSNK1A1-741H Recombinant Human Casein Kinase 1, Alpha 1, GST-His Sf9 Insect Cell GST
Human CSNK1A1-26814TH Recombinant Human CSNK1A1 Sf9 Insect Cell N/A 337 amino acids
Human CSNK1A1-5114H Recombinant Human CSNK1A1, His-tagged E.coli His
Human CSNK1A1-740H Recombinant Human CSNK1A1 protein, His & T7-tagged E.coli His/T7 Lys130~Phe337 (Accession # P48729)
Human CSNK1A1-513H Recombinant Human casein kinase 1, alpha 1, His-tagged E.coli His
Human CSNK1A1-1986H Active Recombinant Human CSNK1A1 Protein, GST-His-tagged Insect Cell GST/His
Human CSNK1A1-1988H Recombinant Human CSNK1A1 Protein, GST-tagged Wheat Germ GST
Human CSNK1A1-617HCL Recombinant Human CSNK1A1 cell lysate Insect Cell N/A
Human CSNK1A1-0205H Recombinant Human CSNK1A1 Protein (A2-F337), GST tagged Insect Cell GST A2-F337
Human CSNK1A1-2745H Recombinant Human CSNK1A1 protein, His-tagged E.coli His 2-337aa
Human CSNK1A1-7170HF Active Recombinant Full Length Human CSNK1A1 Protein, GST-tagged Insect (sf21) GST 1-337
Human CSNK1A1-2189HF Recombinant Full Length Human CSNK1A1 Protein, GST-tagged In Vitro Cell Free System GST 337 amino acids
Human CSNK1A1-0204H Recombinant Human CSNK1A1 Protein (A2-F337), Tag Free Insect Cell No tag A2-F337
Human CSNK1A1-1837H Recombinant Human CSNK1A1 Protein (Lys130-Phe337), N-His tagged E.coli N-His Lys130-Phe337
Rat CSNK1A1-1632R Recombinant Rat CSNK1A1 Protein Mammalian Cell His
Rat Csnk1a1-741R Recombinant Rat Csnk1a1 protein, His & T7-tagged E.coli His/T7 Leu114~Gly324 (Accession # P97633)
Rat CSNK1A1-1290R Recombinant Rat CSNK1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CSNK1A1-1290R-B Recombinant Rat CSNK1A1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CSNK1A1-1058R Recombinant Rhesus monkey CSNK1A1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CSNK1A1-883R Recombinant Rhesus Macaque CSNK1A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CSNK1A1-883R-B Recombinant Rhesus Macaque CSNK1A1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CSNK1A1-3069Z Recombinant Zebrafish CSNK1A1 Mammalian Cell His
Pig CSNK1A1-5407P Recombinant Pig CSNK1A1 Protein (Met1-Phe365), N-His tagged E.coli N-His Met1-Phe365
Pig CSNK1A1-0003P Recombinant Pig CSNK1A1 Protein (Met1-Phe365), C-His-tagged Baculovirus-Insect cells C-His Met1-Phe365
Chicken CSNK1A1-6610C Recombinant Chicken CSNK1A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CSNK1A1 Related Articles
  • CSNK1A1 Related Research Area

CSNK1A1 involved in several pathways and played different roles in them. We selected most pathways CSNK1A1 participated on our site, such as AMER1 mutants destabilize the destruction complex, APC truncation mutants have impaired AXIN binding, AXIN missense mutants destabilize the destruction complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with CSNK1A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Activation of SMOGAS8;CSNK1A1;ADRBK1;KIF3A;CDON;BOC;EFCAB7;IQCE;SETD6
Beta-catenin phosphorylation cascadeFAM123B;CSNK1A1
Canonical Wnt signaling pathwayCSNK1A1;KLHL12;DVL1;DVL2;CSNK1D;DVL3;CSNK1E
Degradation of GLI2 by the proteasome

CSNK1A1 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CSNK1A1 itself. We selected most functions CSNK1A1 had, and list some proteins which have the same functions with CSNK1A1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingACTB1;RAF1;ABCC6;HSPA8;FARS2;EPHA7;ACTA1;HSPA13;EGFRA
protein bindingYTHDC1;FEZ1;MRPL53;PEX11G;DNAL4;SUSD2;PAX9;MTAP1A;CHP
protein kinase activityCSNK1A1;RBM4.3;DYRK1A;EPHB3A;IRAK4;SCYL1;CDK13;CCND1;JAK2A
protein serine/threonine kinase activityPSKH1;MAPK4;ACVRL1;ULK1A;GRK7A;CPNE3;TSSK2;CDK11B;GRK7B

CSNK1A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CSNK1A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CSNK1A1.

RIPK1; MDM4; q63629_rat; SEC16A; AXIN1; FAM83H; MDM2

Juhasz, K; Zvara, A; et al. Casein kinase 2-interacting protein-1, an inflammatory signaling molecule interferes with TNF reverse signaling in human model cells. IMMUNOLOGY LETTERS 152:55-64(2013).
Chiarini, A; Armato, U; et al. Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. PROTEOMICS 9:1850-1860(2009).
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