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Official Full Name casein kinase 1, alpha 1
Background Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A1 gene. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. The kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. The protein encoded by this gene represents the alpha subunit. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different proteins have been found for this gene.
Synonyms CSNK1A1; casein kinase 1, alpha 1; casein kinase I isoform alpha; CK1; CK1a; CK1alpha; CKIa; CKIalpha; clock regulator kinase; CKI-alpha; down-regulated in lung cancer; HLCDGP1; PRO2975
    • Species :
    • Chicken
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CSNK1A1-1986H Recombinant Human CSNK1A1 Protein, GST-His-tagged Insect Cell GST/His
    Human CSNK1A1-1988H Recombinant Human CSNK1A1 Protein, GST-tagged Wheat Germ GST
    Human CSNK1A1-26814TH Recombinant Human CSNK1A1 Sf9 Insect Cell N/A
    Human CSNK1A1-5114H Recombinant Human CSNK1A1, His-tagged E.coli His
    Human CSNK1A1-513H Recombinant Human casein kinase 1, alpha 1, His-tagged E.coli His
    Human CSNK1A1-617HCL Recombinant Human CSNK1A1 cell lysate Insect Cell N/A
    Human CSNK1A1-677H Recombinant Human Casein Kinase 1, Alpha 1, GST-tagged Insect Cell GST
    Human CSNK1A1-740H Recombinant Human CSNK1A1 protein, His & T7-tagged E.coli His/T7
    Human CSNK1A1-741H Recombinant Human Casein Kinase 1, Alpha 1, GST-His Sf9 Insect Cell GST
    Human CSNK1A1-964H Recombinant Human CSNK1A1, GST tagged Insect Cell GST
    Rat CSNK1A1-1632R Recombinant Rat CSNK1A1 Protein Mammalian Cell His
    Rat Csnk1a1-741R Recombinant Rat Csnk1a1 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque CSNK1A1-1058R Recombinant Rhesus monkey CSNK1A1 Protein, His-tagged Mammalian Cell His
    Chicken CSNK1A1-6610C Recombinant Chicken CSNK1A1 Mammalian Cell His
    Zebrafish CSNK1A1-3069Z Recombinant Zebrafish CSNK1A1 Mammalian Cell His

    csnk1a1 involved in several pathways and played different roles in them. We selected most pathways csnk1a1 participated on our site, such as AMER1 mutants destabilize the destruction complex, APC truncation mutants have impaired AXIN binding, AXIN missense mutants destabilize the destruction complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with csnk1a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    AMER1 mutants destabilize the destruction complex CSNK1A1
    APC truncation mutants have impaired AXIN binding CSNK1A1
    AXIN missense mutants destabilize the destruction complex CSNK1A1
    AXIN mutants destabilize the destruction complex, activating WNT signaling CSNK1A1
    Activation of SMO ADRBK1; EFCAB7; CSNK1A1; KIF3A; EVC2; BOC; GAS8; IQCE; CDON; SETD6
    Beta-catenin phosphorylation cascade CSNK1A1; FAM123B
    Canonical Wnt signaling pathway DVL2; DVL3; DVL1; KLHL12; CSNK1E; CSNK1A1; CSNK1D
    Degradation of GLI2 by the proteasome CSNK1A1

    csnk1a1 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by csnk1a1 itself. We selected most functions csnk1a1 had, and list some proteins which have the same functions with csnk1a1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding ATP6V1B2; DGKB; ACTR3B; EIF4A1A; TP53; FRK; MYH4; ABCG5; CMPK2; SUCLG2
    protein binding ATP7A; CASP7; BACH1; EN1; GRIN2B; RPS19BP1; RERG; CCNA2; HMGN2; CDC45
    protein kinase activity MAP4K5; MAP3K12; NLK2; RPS6KA5; EPHB2B; AKT3A; SGK196; NEK2; PRKCHA; SRPK1A
    protein serine/threonine kinase activity PLK3; PLK2B; BSK146; MAP4K5; MASTL; LMTK3; ILK; TNNI3K; CSNK2A1; OXSR1B

    csnk1a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with csnk1a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of csnk1a1.

    RIPK1; MDM4; q63629_rat; SEC16A; AXIN1; FAM83H; MDM2

    Juhasz, K; Zvara, A; et al. Casein kinase 2-interacting protein-1, an inflammatory signaling molecule interferes with TNF reverse signaling in human model cells. IMMUNOLOGY LETTERS 152:55-64(2013).
    Chiarini, A; Armato, U; et al. Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions. PROTEOMICS 9:1850-1860(2009).

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