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Official Full Name cystatin C
Background The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. Alternative splicing results in multiple transcript variants encoding a single protein. [provided by RefSeq, Dec 2013]
Synonyms CST3; cystatin C; ARMD11; cystatin-C; cystatin 3; cystatin-3; gamma-trace; post-gamma-globulin; bA218C14.4 (cystatin C); neuroendocrine basic polypeptide
    • Species :
    • Cattle
    • Chicken
    • Human
    • Mouse
    • Pig
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Human Urine - chronic protein renal tubular proteinuria
    • Insect Cell
    • Mammalian Cell
    • P.pastoris
    • Rabbit
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CST3-11643H Recombinant Human CST3, GST-tagged E.coli GST
    Human CST3-11H Human Cystatin C Reference Standard N/A
    Human CST3-1914H Recombinant Human Cystatin C HEK293 N/A
    Human CST3-2025H Recombinant Human CST3 Protein, GST-tagged Wheat Germ GST
    Human CST3-2044H Recombinant Human CST3 Protein, His-tagged HEK293 His
    Human CST3-222H Recombinant Human CST3 Protein HEK293 N/A
    Human CST3-26152TH Native Human CST3 N/A
    Human CST3-2713H Recombinant Human Cystatin C P.pastoris N/A
    Human CST3-2991HCL Recombinant Human CST3 cell lysate Human Cell N/A
    Human CST3-3172H Recombinant Human CST3, His tagged Human Cell His
    Human CST3-3355H Recombinant Human CST3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CST3-3666H Recombinant Human CST3, His-tagged E.coli His
    Human CST3-3667H Human Cystatin C 1r4c N/A
    Human CST3-376H Recombinant Human CST3 protein E.coli N/A
    Human CST3-4309H Native Human CST3 Protein Human N/A
    Human CST3-50H Recombinant Human CST3 protein, His-tagged E.coli His
    Human CST3-692H Recombinant Human CST3 Mammalian Cell His
    Human CST3-6H Cystatin C in Human Serum Reference Standard N/A
    Human CST3-8100H Native Human Cystatin C (Cystatin 3) Human Urine - chronic protein renal tubular proteinuria N/A
    Mouse CAB11520RM Rabbit Anti-Mouse Cystatin C Monoclonal Antibody Rabbit N/A
    Mouse Cst3-2205M Recombinant Mouse Cst3, His tagged Human Cell His
    Mouse Cst3-246M Recombinant Mouse Cystatin C, His-tagged E.coli His
    Mouse CST3-2470MCL Recombinant Mouse CST3 cell lysate Human Cell N/A
    Mouse Cst3-35M Mouse Cystatin C Reference Standard N/A
    Mouse Cst3-3669M Recombinant Mouse Cst3, His-tagged E.coli His
    Mouse CST3-373M Recombinant Mouse CST3 Protein, His-tagged Insect Cell His
    Mouse Cst3-7182M Recombinant Mouse Cst3 Protein, His-tagged Insect Cell His
    Mouse Cst3-946M Recombinant Mouse Cst3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CST3-1645R Recombinant Rat CST3 Protein Mammalian Cell His
    Rat CST3-1938RCL Recombinant Rat CST3 cell lysate Human Cell N/A
    Rat Cst3-253R Recombinant Rat Cystatin C, His-tagged E.coli His
    Rat Cst3-33R Recombinant Rat Cst3 Protein, His-tagged Insect Cell His
    Rat Cst3-3670R Recombinant Rat Cst3, His-tagged E.coli His
    Rat Cst3-4094R Recombinant Rat Cst3, His tagged Human Cell His
    Rat Cst3-76R Rat Cystatin C Reference Standard N/A
    Rhesus Macaque CST3-1068R Recombinant Rhesus monkey CST3 Protein, His-tagged Mammalian Cell His
    Chicken CST3-7049C Recombinant Chicken CST3 Mammalian Cell His
    Chicken CST3-7898C Recombinant Chicken CST3 protein, His-tagged E.coli His
    Zebrafish CST3-3366Z Recombinant Zebrafish CST3 Mammalian Cell His
    Cattle CST3-7897C Recombinant Cattle CST3 protein, His-tagged E.coli His
    Pig CST3-7899P Recombinant Pig CST3 protein, His & GST-tagged E.coli His/GST

    cst3 involved in several pathways and played different roles in them. We selected most pathways cst3 participated on our site, such as Amyloid formation, Integrated Pancreatic Cancer Pathway, Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with cst3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amyloid formation APCS; SAA1; MFGE8; RHBDL1; HIST4H4; HIST3H2BB; NAT8B; CEACAM21; SEMG1; NAT8
    Integrated Pancreatic Cancer Pathway PPP1R13L; CASP12; NOXA1; GPRC5A; RB1CC1; FKBP1B; BRF1; FKBP3; CST3; TFF1
    Metabolism of proteins BCS1L; TRAPPC9; MCFD2; ADAMTSL3; CXXC1; RHBDL1; TIMM17A; TUBA3D; CCDC59; TOMM40
    Salivary secretion Slc4a2; BEST2; PRKACA; PLCB2; CALM4; PRKG2; ITPR1; CST4; CALML5; PRKACB

    cst3 has several biochemical functions, for example, beta-amyloid binding, cysteine-type endopeptidase inhibitor activity, endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cst3 itself. We selected most functions cst3 had, and list some proteins which have the same functions with cst3. You can find most of the proteins on our site.

    Function Related Protein
    beta-amyloid binding APOA1; APBB3; CHRNA7; ITM2C; OLFM1; APOEB; APOE; BCHE; NGFR; BACE2
    cysteine-type endopeptidase inhibitor activity CSTA; SPOCK1; CST14B.1; NGP; Cstb; CTLA2B; HRG; CARD16; CARD17; CST7
    endopeptidase inhibitor activity SERPINA1D; SPINK1; Serpina1c; A1i3; SLPI; PZP; CST7; ITIH2; WFDC2; CST14B.1
    identical protein binding TRAF6; CBX3; CEACAM5; SMAD4; SOD2; FHL2; RELA; ERBB2; C1S; VAMP2
    protease binding RYR1; KIT; CNTNAP2; CCBE1; ALPI; Serpina1c; ADAMTS4; TNF; BCL10; TIMP2A
    protein binding AHR; SF3A1; CTGF; BTN2A2; ZNF398; TRIM44; ATP1A2; LARP4B; ARF5; MED1

    cst3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cst3 here. Most of them are supplied by our site. Hope this information will be useful for your research of cst3.

    ATXN1; proS; gmhB; ALB

    Wuttke, M; Schaefer, F; et al. Genome-Wide Association Studies in Nephrology: Using Known Associations for Data Checks. AMERICAN JOURNAL OF KIDNEY DISEASES 65:217-222(2015).
    Lamontagne, M; Timens, W; et al. Genetic regulation of gene expression in the lung identifies CST3 and CD22 as potential causal genes for airflow obstruction. THORAX 69:997-+(2014).

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