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Official Full Name cystatin S
Background The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes a type 2 salivary cysteine peptidase inhibitor. The protein is an S-type cystatin, based on its high level of expression in saliva, tears and seminal plasma. The specific role in these fluids is unclear but antibacterial and antiviral activity is present, consistent with a protective function.
Synonyms CST4; cystatin S; cystatin-S; Cystatin 4; Cystatin S precursor; Cystatin SA III; Cystatin-4; Cystatin-SA-III; CYTS_HUMAN; MGC71923; Salivary acidic protein 1; OTTHUMP00000030443
    • Species :
    • Human
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Mouse
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CAB11521MH Mouse Anti-Human Cystatin S Monoclonal Antibody Mouse N/A
    Human CST4-2027H Recombinant Human CST4 Protein, GST-tagged Wheat Germ GST
    Human CST4-2241HCL Recombinant Human CST4 cell lysate Human Cell N/A
    Human CST4-27162TH Recombinant Human CST4 Wheat Germ N/A
    Human CST4-3212H Recombinant Human CST4 protein, His-tagged HEK293 His
    Human CST4-3353H Recombinant Human CST4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CST4-378H Recombinant Human CST4 Protein, His-tagged Insect Cell His
    Human CST4-5793H Recombinant Human CST4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CST4-6768H Recombinant Human CST4, His-tagged E.coli His
    Rat CYSS-1762R Recombinant Rat CYSS Protein Mammalian Cell His

    CST4 involved in several pathways and played different roles in them. We selected most pathways CST4 participated on our site, such as Salivary secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CST4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Salivary secretion GNAQ; RYR3; CST3; PLCB1; CST1; GUCY1A3; STATH; PRKG1; Slc4a2; PLCB3

    CST4 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CST4 itself. We selected most functions CST4 had, and list some proteins which have the same functions with CST4. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type endopeptidase inhibitor activity CARD16; CST9; CSTA; SPOCK1; KNG1; HRG; SERPINB3; CSTL1; BIRC5; CST8

    CST4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CST4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CST4.

    SOD2; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate

    Zhang, Q; Zhao, XZ; et al. Expression and purification of soluble human cystatin C in Escherichia coli with maltose-binding protein as a soluble partner. PROTEIN EXPRESSION AND PURIFICATION 104:14-19(2014).
    Fine, JD; Bruckner-Tuderman, L; et al. Inherited epidermolysis bullosa: Updated recommendations on diagnosis and classification. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 70:1103-1126(2014).

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