CTAG1B
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Official Full Name
cancer/testis antigen 1B
- Recombinant Proteins
- Cell & Tissue Lysates
- Human
- E.coli
- HEK293
- Human
- Human cells
- Insect Cell
- Mamanlian cells
- DDK
- DYKDDDDK
- Flag
- GST
- His
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | CTAG1B-1512H | Recombinant Human Cancer/Testis Antigen 1B | E.coli | N/A |
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| Human | CTAG1B-215H | Recombinant Human CTAG1B protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | CTAG1B-15H | Recombinant Human CTAG1B protein, GST-tagged | E.coli | GST | ||
| Human | CTAG1B-26H | Recombinant Human CTAG1B protein, DDK-tagged | Insect Cell | DDK |
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| Human | CTAG1B-4480H | Recombinant Human Cancer/testis Antigen 1B, GST-tagged | Human | GST |
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| Human | CTAG1B-16H | Recombinant Human CTAG1B protein, His-tagged | E.coli | His | Met1~Arg180 | |
| Human | CTAG1B-26434TH | Recombinant Human CTAG1B, GST-tagged | E.coli | GST |
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| Human | CTAG1B-7218HCL | Recombinant Human CTAG1B 293 Cell Lysate | HEK293 | N/A |
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| Human | CTAG1B-01H | Recombinant Human CTAG1B Protein, DYKDDDDK-tagged | Human cells | DYKDDDDK |
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| Human | CTAG1B-4403HFL | Recombinant Full Length Human CTAG1B protein, Flag-tagged | Mamanlian cells | Flag |
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- Background
- Quality Guarantee
- Case Study
- Involved Pathway
- Protein Function
- Interacting Protein
- CTAG1B Related Research Area
What is CTAG1B protein?
CTAG1B (cancer/testis antigen 1B) is a protein coding gene which situated on the long arm of chromosome X at locus Xq28. An important paralog of this gene is CTAG1A. The protein encoded by this gene is called CTAG1B also known as NY-ESO-1. It is a member of the CT (cancer/testis) family, also a tumor-specific shared antigen with distinctive immunogenicity. Both the cytotoxic T lymphocyte and antibody have been shown to react with this CTAG1B. The CTAG1B protein is consisted of 180 amino acids and its molecular mass is approximately 18 kDa. CTAG1B has been detected in normal testis and in a range of human tumor types whose reactivity in testis is restricted to germ cells, particularly in the spermatogonia.
What is the function of CTAG1B protein?
The precise function of CTAG1B is not fully understood, but it is believed to play a role in cancer progression and immune response. CTAG1B is known to be involved in tumor cell proliferation, invasion, and metastasis. It may also contribute to the evasion of immune surveillance by promoting immune tolerance in tumor cells.
CTAG1B related Signaling pathways
In terms of signaling pathways, CTAG1B is known to be involved in the Wnt signaling pathway, which plays a critical role in cell proliferation, differentiation, and tumorigenesis. CTAG1B has been shown to interact with the β-catenin protein, a key component of the canonical Wnt signaling pathway, suggesting its involvement in this pathway.
CTAG1B Related Diseases
CTAG1B is primarily expressed in various cancer types such as lung cancer, breast cancer, bladder cancer, and melanoma. Its expression is often associated with more aggressive tumor characteristics and poor prognosis.
Fig1. NY-ESO-1 expression in the patients with no distant metastasis was 24.62% (32/130), but it was as high as 46.15% (12/26) in the patients with distant metastasis (p=0.026).
Bioapplications of CTAG1B
The potential of CTAG1B as a cancer biomarker and therapeutic target is being explored. It is being studied for its potential use in cancer immunotherapy, specifically in the development of cancer vaccines and targeted immunotherapies that induce an immune response against cancer cells expressing CTAG1B. CTAG1B can also be used in immunotherapy to activate the immune system and enhance the body's immunity to tumors.
High Purity
Fig1. SDS-PAGE (CTAG1B-16H) (PROTOCOL for western blot)
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Fig2. SDS-PAGE (CTAG1B-01H)
Case Study 1: Veerauo V Konkankit, 2011
Fig1. Up-regulated expression of NY-ESO-1 in human glioma-derived cell lines and primary cell lines treated with decitabine. Representative data for established glioma cell lines.
Case Study 2: Alaa Alsalloum, 2023
Fig2. Box plot analysis of transduced T cell population clusters following NY-ESO-1-expressing SK-MEL-37 cell line cultivation.
CTAG1B involved in several pathways and played different roles in them. We selected most pathways CTAG1B participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CTAG1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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CTAG1B has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTAG1B itself. We selected most functions CTAG1B had, and list some proteins which have the same functions with CTAG1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FAH;PELI2;IRF9;CKS1B;PSMB2;FOSL2;UIMC1;CWC22;MXD3 |
CTAG1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTAG1B here. Most of them are supplied by our site. Hope this information will be useful for your research of CTAG1B.
UBQLN1; UBQLN1; MAGEC1
- Q&As
- Reviews
Q&As (5)
Ask a questionCTAG1B expression profiling can help in tailoring personalized cancer treatments by identifying patients who may benefit from specific immunotherapeutic approaches.
The expression of CTAG1B in cancer cells is significant as it can serve as a potential biomarker for cancer diagnosis and prognosis.
CTAG1B expression is commonly observed in a variety of cancers, including melanoma, lung cancer, and bladder cancer.
Yes, some diagnostic tests, such as immunohistochemistry (IHC), may use CTAG1B protein expression to aid in cancer diagnosis.
Yes, monitoring CTAG1B levels during cancer treatment can provide valuable information about the effectiveness of the therapy and potential relapse risks.
Customer Reviews (3)
Write a reviewThe Aldehyde Protein exhibits an exceptional level of quality that surpasses my experimental requirements.
Its impeccable purity and consistency have consistently delivered accurate and robust results, enabling me to make significant strides in my research.
One remarkable aspect of the CTAG1B Protein is the outstanding technical support provided by the manufacturer.
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