CTPS2
-
Official Full Name
CTP synthase II
-
Overview
The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. -
Synonyms
CTPS2; CTP synthase II; CTP synthase 2; CTP synthetase 2; CYTIDINE 5 PRIME TRIPHOSPHATE SYNTHETASE 2; FLJ43358; MGC32997; PYRG2_HUMAN; UTP--ammonia ligase 2; UTP-ammonia ligase; CTP synthetase type 2; CTP synthetase isoform; cytidine 5-triphosphate synthetase 2;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- Flag
- His
- GST
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- CTPS2 Related Articles
CTPS2 involved in several pathways and played different roles in them. We selected most pathways CTPS2 participated on our site, such as Pyrimidine metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTPS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyrimidine metabolism | NT5C1B;CDA;ZNRD1;POLR3E;POLD1;POLA2;DCTPP1;POLR2EB;NME7 |
| Metabolic pathways | B3GNT5;GALNT11;ALDH4A1;B4GALT6;PYCR1B;PIGO;UAP1L1;DCT;P4HA3 |
CTPS2 has several biochemical functions, for example, ATP binding, CTP synthase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CTPS2 itself. We selected most functions CTPS2 had, and list some proteins which have the same functions with CTPS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP2A1L;CHD9;UBE2Q2;PIP4K2A;CENPE;IRAK2;GLYCTK;MARK4;TNK1 |
| CTP synthase activity | CTPS2;CTPS1A |
| protein binding | PROX1;RUVBL1;TRAF5;PPP6R3;MMS19;PLEKHF1;NBN;RMND5A;TOR1A |
CTPS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTPS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTPS2.
SPG21; OTUD5; FGFR1; CTBP2; RPL37A; RPL23A; 15-deoxy-delta(12,14; SNX3; NASP
- Q&As
- Reviews
Ask a Question for All CTPS2 Products
Required fields are marked with *
My Review for All CTPS2 Products
Required fields are marked with *
