CTSL2

  • Official Full Name

    Cathepsin L2

  • Overview

    Cathepsin V, also known as Cathepsin L2, is a 334 amino acid protein that belongs to the peptidase C1 family and is found in the lysosome. It is a Cysteine protease that may have an important role in corneal physiology. It can also function as a hydrolase and thiol protease. The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec). Cathepsin V is expressed predominantly in the thymus and testis. It is also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin.

  • Synonyms

    UNQ268/PRO305;CATL2;CTSU;CTSV;cathepsin L2, preproprotein;cathepsin U;cathepsin V

Recombinant Proteins

  • Human
  • Chicken
  • Human Cells
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CTSL2-614H Recombinant Human CTSL2, His tagged Human Cells Human His Full L. 1-334 a.a.
CTSL2-4041C Recombinant Chicken CTSL2 Mammalian Cells Chicken His
CTSL2-507H Recombinant Human Cathepsin L2, His-tagged HEK293 Human His 1-16;18-334 a.a.
CTSL2-681H Recombinant Human Cathepsin L2, His-tagged Insect Cells Human His
CTSL2-751H Recombinant Human Cathepsin L2, His-tagged Mammalian Cells Human His 18-334 a.a.
CTSL2-7191HCL Recombinant Human CTSL2 293 Cell Lysate HEK293 Human Non
CTSL2-2755H Recombinant Human CTSL2 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
CTSL2-2755H-B Recombinant Human CTSL2 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    CTSL2 involved in several pathways and played different roles in them. We selected most pathways CTSL2 participated on our site, such as Activation of Matrix Metalloproteinases,Adaptive Immune System,Antigen processing-Cross presentation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CTSL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Antigen processing-Cross presentation CTSS,CYBB,CD207,CTSL1,FCGR1B,SEC61B,CYBA
    Endochondral Ossification COL10A1,PTHLH,KIF3A,MGP,FRZB,CDKN1C,ADAMTS4,SERPINH1,ADAMTS1,COL10A1A
    Degradation of the extracellular matrix MMP13,CMA1,MMP10,TIMP2,CTSS,ADAM9,COL17A1,CTRB1,NID1,FAM49BA
    Assembly of collagen fibrils and other multimeric structures PCOLCE,COL1A2,COL3A1,COL6A1,COL4A4,BMP1A,LOXL2,COL4A5,PLEC,CTSB
    Class I MHC mediated antigen processing &amp ATG7,SPSB2,MKRN1,ASB9,RNF138,RNF220,UBE2V1,UBE2J2,UBE2L6,HUWE1
    Activation of Matrix Metalloproteinases TIMP2A,CTSG,MGC174152,FURINA,CTRB1,ELANE,CMA1,MMP13,MGC174155,LOC100686744
    Adaptive Immune System ERAP2,TRIM41,WSB1,SH2D1B,ARIH2,ASB13,CDKN1A,SIGLEC9,SPSB4,CTSS
    Collagen formation LOXL3,COL19A1,COL10A1A,COL5A3A,COL13A1,ABHD1,COL8A1,CTSB,COL9A1A,PPIB
    presentation RNF4,ASB7,SEC23A,STUB1,TRIM69,ASB14,RNF138,ASB3,RNF41,RNF25

    Protein Function

    CTSL2 has several biochemical functions, for example, aminopeptidase activity,cysteine-type carboxypeptidase activity,cysteine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CTSL2 itself. We selected most functions CTSL2 had, and list some proteins which have the same functions with CTSL2. You can find most of the proteins on our site.

    Function Related Protein
    cysteine-type peptidase activity CAPN2L,USP43A,FAM49BA,CTSSB.1,CASP3B,Ctsl,USP17L3,CTSH,CASP7,SENP8
    cysteine-type carboxypeptidase activity Ctsl
    protein binding ETNK1,UGGT1,MST1R,ZNF232,SELPLG,MED20,HDAC2,ADAP1,INSR,KIAA1143
    protein complex binding GNB1,COG2,FBLN1,KHDRBS1,UQCRC2,PGAM5,CALCA,UGT1A6B,IST1,ABP1
    histone binding HIST1H3I,PHF21B,SUPT6H,BRDT,NASP,HIST1H3A,ZMYND11,DTX3L,CD1d1,HIST1H3F
    peptide binding ANPEPB,CMA1,LTA4H,ADNP,PPIB,RPS6KB2,NPFFR1L2,CRHBP,HCRTR1,PPYR1
    kininogen binding CTSB,C1QBP,Ctsl
    aminopeptidase activity TRHDE,ENPEP,BLMH,METAP1,XPNPEP3,CTSH,METAP2A,ANPEP,METAP1D,ERAP2
    cysteine-type endopeptidase activity MALT1,USP18,USP20,BLMH,ATG4D,CTSBA,CASP6L2,CASPC,CASPA,USP43

    Interacting Protein

    CTSL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CTSL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CTSL2.

    srp-6;BUB1;RB1;SRC;BRAF;APC;CTNNA1;BMPR1A;MLH1;DCC;PDGFRL;CDKN2A;DLC1;MLH3

    Resources

    Research Area

    Lysosomal Enzymes

    References

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