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Official Full Name cytochrome b5 reductase 3
Background This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the;endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form;exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of;fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble;fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both;membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing;results in multiple transcript variants. Mutations in this gene cause methemoglobinemias.
Synonyms CYB5R3; cytochrome b5 reductase 3; DIA1, diaphorase (NADH) (cytochrome b 5 reductase); NADH-cytochrome b5 reductase 3; B5R; Cytochrome b5 reductase; DIA1; Diaphorase 1; Diaphorase-1; NADH cytochrome b5 reductase 3; NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form; NB5R3_HUMAN; OTTHUMP00000028761; OTTHUMP00000198435; OTTHUMP00000198574; OTTHUMP00000198662; OTTHUMP00000198665
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYB5R3-1380H Recombinant Human CYB5R3 Protein, His-tagged E.coli His
    Human CYB5R3-2218H Recombinant Human CYB5R3 Protein, GST-tagged Wheat Germ GST
    Human CYB5R3-7141HCL Recombinant Human CYB5R3 293 Cell Lysate HEK293 N/A
    Human CYB5R3-868H Recombinant Human CYB5R3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse CYB5R3-4127M Recombinant Mouse CYB5R3 Protein Mammalian Cell His
    Mouse Cyb5r3-433M Recombinant Mouse Cyb5r3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat CYB5R3-1705R Recombinant Rat CYB5R3 Protein Mammalian Cell His
    Rhesus Macaque CYB5R3-1127R Recombinant Rhesus monkey CYB5R3 Protein, His-tagged Mammalian Cell His
    Chicken CYB5R3-5509C Recombinant Chicken CYB5R3 Mammalian Cell His
    Zebrafish CYB5R3-11961Z Recombinant Zebrafish CYB5R3 Mammalian Cell His

    CYB5R3 involved in several pathways and played different roles in them. We selected most pathways CYB5R3 participated on our site, such as Amino sugar and nucleotide sugar metabolism, Metabolism, Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYB5R3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amino sugar and nucleotide sugar metabolism UGP2A; GNE; UAP1L1; UGP2B; HKDC1; GMPPA; CMASA; CHIA; GPIA; UGDH
    Metabolism SCO1; TIMMDC1; Agmo; CYP2K8; MPC1; APOA4B.2; UGT1B7; UGT1B3; SULT1C2; SLC23A2
    Metabolism of vitamins and cofactors KCNG4; GSTO2; SLC2A3; TCN1; SLC5A6A; SLC25A32B; SLC25A32; CYB5R3; SLC25A16; CYB5A
    Metabolism of water-soluble vitamins and cofactors SLC19A2; SLC2A3; SLC52A3; GPHNA; ELA2; CTRC; ELA2L; MOCOS; GPHN; CD320
    Vitamin C (ascorbate) metabolism CYB5A; SLC23A2; CYB5R3
    cytochrome P450 CYP2A7; CYB5A; CYB5R3; POR; CYP20A1; CYP4V2; CYP2W1; CYB5B; CYP4Z1; CYP4F12

    CYB5R3 has several biochemical functions, for example, ADP binding, AMP binding, FAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYB5R3 itself. We selected most functions CYB5R3 had, and list some proteins which have the same functions with CYB5R3. You can find most of the proteins on our site.

    Function Related Protein
    ADP binding VCP; ACTA1; MYO3A; ADCK3; MYH10; GLUD1; MYO9B; ME1; PRPS2; MIEF1
    NAD binding HSD17B10; NDUFS2; GPD1L; GAPDHS; CTBP1; HSD3B5; IDH3G; DLD; HSD11B2; GLYR1
    cytochrome-b5 reductase activity, acting on NAD(P)H CYB5R3; NQO1; CYB5R4; POR; CYB5RL; CYB5R2; CYB5R1
    flavin adenine dinucleotide binding AIFM2; FOXRED2; ACADM; PPOX; ETFDH; MAOA; DLD; AOX3L1; KMO; TXNRD1

    CYB5R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYB5R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYB5R3.

    fad; PRKAB1; 1C; P

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