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CYB5R3

  • Official Full Name

    cytochrome b5 reductase 3

  • Overview

    This gene encodes cytochrome b5 reductase, which includes a membrane-bound form in somatic cells (anchored in the;endoplasmic reticulum, mitochondrial and other membranes) and a soluble form in erythrocytes. The membrane-bound form;exists mainly on the cytoplasmic side of the endoplasmic reticulum and functions in desaturation and elongation of;fatty acids, in cholesterol biosynthesis, and in drug metabolism. The erythrocyte form is located in a soluble;fraction of circulating erythrocytes and is involved in methemoglobin reduction. The membrane-bound form has both;membrane-binding and catalytic domains, while the soluble form has only the catalytic domain. Alternate splicing;results in multiple transcript variants. Mutations in this gene cause methemoglobinemias.
  • Synonyms

    CYB5R3; cytochrome b5 reductase 3; DIA1, diaphorase (NADH) (cytochrome b 5 reductase); NADH-cytochrome b5 reductase 3; B5R; Cytochrome b5 reductase; DIA1; Diaphorase 1; Diaphorase-1; NADH cytochrome b5 reductase 3; NADH-cytochrome b5 reductase 3 membrane-bound form; NADH-cytochrome b5 reductase 3 soluble form; NB5R3_HUMAN; OTTHUMP00000028761; OTTHUMP00000198435; OTTHUMP00000198574; OTTHUMP00000198662; OTTHUMP00000198665;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYB5R3-2218H Recombinant Human CYB5R3 Protein, GST-tagged Wheat Germ GST
Human CYB5R3-1380H Recombinant Human CYB5R3 Protein, His-tagged E.coli His 27-301 aa
Human CYB5R3-7141HCL Recombinant Human CYB5R3 293 Cell Lysate HEK293 N/A
Human CYB5R3-2039HFL Recombinant Full Length Human CYB5R3 Protein, C-Flag-tagged Mammalian cells Flag
Human CYB5R3-868H Recombinant Human CYB5R3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CYB5R3-695H Recombinant Human CYB5R3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CYB5R3-695H-B Recombinant Human CYB5R3 Protein Pre-coupled Magnetic Beads HEK293
Mouse CYB5R3-4127M Recombinant Mouse CYB5R3 Protein Mammalian Cell His
Mouse CYB5R3-2114M Recombinant Mouse CYB5R3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cyb5r3-433M Recombinant Mouse Cyb5r3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CYB5R3-2114M-B Recombinant Mouse CYB5R3 Protein Pre-coupled Magnetic Beads HEK293
Rat CYB5R3-1705R Recombinant Rat CYB5R3 Protein Mammalian Cell His
Rat CYB5R3-1364R-B Recombinant Rat CYB5R3 Protein Pre-coupled Magnetic Beads HEK293
Rat CYB5R3-1364R Recombinant Rat CYB5R3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CYB5R3-1127R Recombinant Rhesus monkey CYB5R3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CYB5R3-952R Recombinant Rhesus Macaque CYB5R3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CYB5R3-952R-B Recombinant Rhesus Macaque CYB5R3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CYB5R3-11961Z Recombinant Zebrafish CYB5R3 Mammalian Cell His
Chicken CYB5R3-5509C Recombinant Chicken CYB5R3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CYB5R3 involved in several pathways and played different roles in them. We selected most pathways CYB5R3 participated on our site, such as Amino sugar and nucleotide sugar metabolism, Metabolism, Metabolism of vitamins and cofactors, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYB5R3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amino sugar and nucleotide sugar metabolismTSTA3;PGM3;NAGK;CHIA.4;FPGT;CHIT1;FUK;CYB5R4;GMPPAB
MetabolismARSH;ESRRA;NHLRC1;ST3GAL3A;B4GALT7;DSEL;CA5B;ARSF;APOEA
Metabolism of vitamins and cofactorsSLC25A16;SLC5A6B;SLC52A3;CTRC;MOCOS;LOC100686744;GPHN;CYB5R3;SLC25A32A
Metabolism of water-soluble vitamins and cofactorsSLC19A2;SLC2A3;GPHNA;TCN1;SLC25A32B;CBLC-1;ELA2;SLC25A32A;SLC5A6B
Vitamin C (ascorbate) metabolismSLC23A2;CYB5R3;CYB5A
cytochrome P450CYB5R3;CYP4V2;CYP4Z1;POR;CYB5A;CYP2A7;CYP2W1;CYP20A1;CYB5B

CYB5R3 has several biochemical functions, for example, ADP binding, AMP binding, FAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYB5R3 itself. We selected most functions CYB5R3 had, and list some proteins which have the same functions with CYB5R3. You can find most of the proteins on our site.

Function Related Protein
ADP bindingCHORDC1;ATP1A1;ME1;MIEF1;ERN1;GLUD1;TAP1;P2RY1;MYO9B
AMP bindingACSS1;PRPS2;PRPS1;PRKAG1;FBP1;ACSS2;PRKAG2;CYB5R3;PYGL
FAD bindingDAO1;ACOX1;DAO;PRODH;MTRR;DERL3;AGPS;MICAL2B;DAO.2
NAD bindingGRHPRB;HADHA;HSD17B10;GPD1C;GPD1L;NNT;GPD1B;ADH4;IDH3A
cytochrome-b5 reductase activity, acting on NAD(P)HCYB5R3;CYB5R4;POR;CYB5RL;CYB5R2;CYB5R1;NQO1
flavin adenine dinucleotide bindingKMO;KDM1B;NOS2;KDM1A;ACADL;CYB5R3;IVD;MTHFR;CRY-DASH

CYB5R3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYB5R3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYB5R3.

fad; PRKAB1; 1C; P

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