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CYP2A7

Official Full Name

cytochrome P450, family 2, subfamily A, polypeptide 7
Overview

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q.
Synonyms

CYP2A7; cytochrome P450, family 2, subfamily A, polypeptide 7; cytochrome P450, subfamily IIA (phenobarbital inducible), polypeptide 7; cytochrome P450 2A7; CYP2A; CP2A7_HUMAN; CPA7; CPAD; CYP2A 7; CYPIIA7; Cytochrome P450 IIA4; P450 IIA4; cytochrome P450, subfamily IIA (phenobarbital-inducible), polypeptide 7; P450-IIA4;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CYP2A7-2259H	Recombinant Human CYP2A7 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CYP2A7-7115HCL	Recombinant Human CYP2A7 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CYP2A7-7116HCL	Recombinant Human CYP2A7 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CYP2A7-2392H	Recombinant Human CYP2A7 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CYP2A7-2365HF	Recombinant Full Length Human CYP2A7 Protein, GST-tagged	In Vitro Cell Free System	GST	494 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein

CYP2A7 involved in several pathways and played different roles in them. We selected most pathways CYP2A7 participated on our site, such as Biological oxidations, CYP2E1 reactions, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Biological oxidations	ADH1C;ACSM1;CYP4F11;CYP3C1;ADH8B;NAT2;AADAC;CYP2R1;CYP19A1
CYP2E1 reactions	CYP2C8;CYP2D6;CYP2S1;CYP2C9;CYP2Y3;CYP2A7;CYP2B6;CYP2F1;CYP2A13
Cytochrome P450 - arranged by substrate type	FAM84B;CYP2K6;CYP2C9;CYP2K22;CYP46A1;CYP2R1;CYP2N13;CYP4T8;CYP2V1
Fatty acids	CYP2B6;CYP2AD3;CYP2A7;CYP2A13;CYP2V1;CYP2D6;CYP4T8;CYP4B1;CYP2J2
Metabolism	SYT5;NEU3;CERS4A;CYP2K8;TYMP;DCK;ESRRA;NDUFAF6;HAS3
Phase 1 - Functionalization of compounds	CYP3C1;CYP2S1;CYP2Y3;ADH8A;CES1;CYP2K8;CYP27B1;CYP2C18;CYP2K16
Xenobiotics	CYP3C4;CYP3C1;CYP2W1;CYP2A7
cytochrome P450	CYP2A7;CYP4V2;CYB5A;POR;CYP4F12;CYB5R3;CYP4Z1;CYB5B;CYP20A1

CYP2A7 has several biochemical functions, for example, arachidonic acid epoxygenase activity, aromatase activity, heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2A7 itself. We selected most functions CYP2A7 had, and list some proteins which have the same functions with CYP2A7. You can find most of the proteins on our site.

Function	Related Protein
arachidonic acid epoxygenase activity	CYP2C19;CYP4A11;CYP2P6;CYP2C37;CYP2A7;CYP2AA12;CYP2C70;CYP2C39;CYP2A12
aromatase activity	CYP4X1;CYP2F1;CYP2C37;CYP2H1;CYP2D9;CYP2C54;CYP1A;CYP3A43;CYP2C50
heme binding	CYP51;CYP2AA3;CYP3A4;HEBP1;CYBB;CYP2AA4;NOS3;HRG;CYP2U1
iron ion binding	CYP1A;CYP27A1;CYP26C1;CYP4F3;ALOX5B.3;PHF2;HBM;CYP19A1A;CYP1B1
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2J5;CYP2F1;CYP2C70;CYP2C37;CYP2AD3;CYP2C8;CYP2C54;CYP1D1;CYP2C39
oxygen binding	CBS;TDO2;CYP2P7;CYP2K6;CYP2A7;HBBE2;CYP3A7;HBG1;CYP2AA2
steroid hydroxylase activity	CYP2AA12;CYP2D9;CYP2C50;CYP2X10.2;FAM84B;CYP2AA7;CYP2U1;CYP2C55;CYP2P7

CYP2A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2A7.