CYP2F1
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Official Full Name
CYP2F1 cytochrome P450, family 2, subfamily F, polypeptide 1 [ Homo sapiens ] -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to dehydrogenate 3-methylindole, an endogenous toxin derived from the fermentation of tryptophan, as well as xenobiotic substrates such as naphthalene and ethoxycoumarin. This gene is part of a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. -
Synonyms
CYPIIF1;Cytochrome P450 2F1;cytochrome P450, family 2, subfamily F, polypeptide 1;EC=1.14.14.1;flavoprotein-linked monooxygenase;microsomal monooxygenase;EC 1.14.14.1;xenobiotic monooxygenase
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| CYP2F1-11776H | Recombinant Human CYP2F1, GST-tagged | E.coli | Human | GST | 142-302a.a. | |
| CYP2F1-139H | Recombinant Human CYP2F1 Protein, His-tagged | E.coli | Human | His | 142-302 aa | |
| CYP2F1-1155R | Recombinant Rhesus monkey CYP2F1 Protein, His-tagged | Mammalian Cells | Rhesus macaque | His |
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| CYP2F1-2267H | Recombinant Human CYP2F1 Protein, GST-tagged | Wheat Germ | Human | GST |
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| CYP2F1-980R | Recombinant Rhesus Macaque CYP2F1 Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | Avi&Fc&His |
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| CYP2F1-980R-B | Recombinant Rhesus Macaque CYP2F1 Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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Involved Pathway
CYP2F1 involved in several pathways and played different roles in them. We selected most pathways CYP2F1 participated on our site, such as Biological oxidations,CYP2E1 reactions,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP2F1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tryptophan metabolism | ALDH2.2,ALDH9A1,ALDH3A2A,IL4I1,HADH,AOX3,AOX1,TPH1,MAOB,TDO2A |
| Cytochrome P450 - arranged by substrate type | CYP27B1,CYP2A6,CYP2E1,CYP3A4,CYP2K17,CYP2J2,FDXR,CYP4T8,CYP11B2,CYP2AD2 |
| Fatty acids | CYP4B1,CYP2J2,CYP4F12,CYP4F22,CYP2AD3,CYP4T8,CYP2A7,CYP2N13,CYP2D6,CYP2V1 |
| Metabolism of xenobiotics by cytochrome P450 | AKR1C2,ADH2-2,AKR1C4,ADH2-1,CYP2S1,PRKRA,GSTK1 |
| Metabolism | GPHN,NUDT3,COX5B,ATP5H,PNPLA8,NUDT3A,LMF2,NDUFS7,CYP2S1,CYP2K16 |
| Biological oxidations | CYP2K16,CYP2K18,CYP7A1,NAT2,CYP2C19,CYP46A1,AHCY,Sult2a6,SLC35B3,CYP2B6 |
| CYP2E1 reactions | CYP2A7,CYP2D6,CYP2S1,CYP2Y3,CYP2B6,CYP2C8,CYP2C19,CYP2A13,CYP2C9,CYP2A6 |
| Phase 1 - Functionalization of compounds | CYP46A1,CYP2K8,CYP2K19,CYP2AD2,CYP2R1,CYP26A1,CYP2AD6,CYP2C18,CYP2U1,CES1 |
Protein Function
CYP2F1 has several biochemical functions, for example, arachidonic acid epoxygenase activity,aromatase activity,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP2F1 itself. We selected most functions CYP2F1 had, and list some proteins which have the same functions with CYP2F1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2C70,CYP2AA9,CYP2A13,CYP2A4,CYP2J2,CYP2X10.2,CYP2AA8,CYP2A6,CYP2C38,CYP2C50 |
| aromatase activity | CYP2C18,CYP2C9,CYP2D26,CYP2C38,CYP4Z1,CYP4X1,CYP3A25,CYP3A5,CYP2C39,CYP3A43 |
| arachidonic acid epoxygenase activity | CYP2A13,CYP2N13,CYP2J6,CYP2Y3,CYP2C9,CYP2C55,CYP2AA7,CYP2S1,CYP2P9,CYP2AA4 |
| heme binding | HBBE3,CYP1A,CYP2U1,CYP2K22,CYP2AA4,CYP2H1,HBA-A2,CYP2X10.2,HRG-1,CYP21A2 |
| monooxygenase activity | YWHAQB,CYP2AA12,CYP3A7,FOXRED2,CYP51,CYP8B3,CYP19A1B,CYP4A10,CYP4V8,CYP3C1 |
| oxygen binding | CYP2AA12,CYP2F2,CYP2Y3,TDO2,CYP2U1,CYP2W1,CYGB,CYP2D9,HBM,HBB-BH1 |
| iron ion binding | SLC11A2,EGLN1,TPH1A,SC5DL,HBAD,PHF8,TYW1B,CYP26B1,CYP2K22,HBQ1 |
| steroid hydroxylase activity | CYP2K6,CYP2C54,CYP2P6,CYP2C70,CYP2E1,CYP2C9,CYP2C39,CYP2P9,CYP2A12,BRSK2 |
Interacting Protein
CYP2F1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP2F1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP2F1.
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References
- Kull, S; Schulz, KM; et al. Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype. PLOS ONE 10:-(2015).
- Chen, PC; Syu, GD; et al. Antibody Profiling of Bipolar Disorder Using Escherichia coli Proteome Microarrays. MOLECULAR & CELLULAR PROTEOMICS 14:510-518(2015).
