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Official Full Name cytochrome P450, family 46, subfamily A, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism.
Synonyms CYP46A1; cytochrome P450, family 46, subfamily A, polypeptide 1; CYP46, cytochrome P450, subfamily 46 (cholesterol 24 hydroxylase); cholesterol 24-hydroxylase; CH24H; cytochrome P450 46A1; cytochrome P450, subfamily 46 (cholesterol 24-hydroxylase); CP46
    • Species :
    • Chicken
    • Human
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP46A1-03H Recombinant Human CYP46A1 Protein E.coli
    Human CYP46A1-11786H Recombinant Human CYP46A1, His-tagged E.coli His
    Human CYP46A1-258H Recombinant Human CYP46A1 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CYP46A1-259H Recombinant Human CYP46A1 protein, GST-tagged Wheat Germ GST
    Human CYP46A1-7105HCL Recombinant Human CYP46A1 293 Cell Lysate HEK293 N/A
    Chicken CYP46A1-4530C Recombinant Chicken CYP46A1 Mammalian Cell His

    cyp46a1 involved in several pathways and played different roles in them. We selected most pathways cyp46a1 participated on our site, such as Bile acid and bile salt metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with cyp46a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Bile acid and bile salt metabolism AKR1C21; CYP7A1; CYP46A1; SCP2B; SLCO1B1; Alb; CYP8B2; SLC27A5; AKR1C6; CYP27A1
    Biological oxidations DPEP1; CES1; GGT6; CYP2AD3; ADH1B; GSTK1; ADH7; CYP2F1; GSTO2; CYP4F11
    Cytochrome P450 - arranged by substrate type CYP2K8; CYP17A1; CYP2C8; CYP3A4; FAM84B; CYP2C9; CYP51A1; CYP2K6; CYP4B1; CYP3A5
    Endogenous sterols CYP11B1; CYP46A1; CYP17A1; FDX1; CYP8B2; CYP11A1; CYP11B2; FDX1L; CYP51A1; CYP19A1
    Metabolism CYP46A1; TPH2; Sult2a6; AQP1A.1; CETP; PPM1LA; CYP3A5; ACOT2; ARSE; HS3ST6
    Metabolism of lipids and lipoproteins CYP4T8; MED8; CLPS; ELOVL1A; CYP27A1; FABP11B; FABP11A; ARSI; ACSF3; MED26
    Phase 1 - Functionalization of compounds CYP3C1; CYP2R1; CYP2K18; AADAC; CYP2AD6; CYP2K22; CYP4T8; CYP3A7-CYP3AP1; CYP2S1; CYP2W1
    Primary bile acid biosynthesis AMACR; BAAT; CYP7A1A; ACOX2; CH25HL1.2; AKR1D1; CYP46A1.2; SCP2A; AKR1C4; SLC27A5

    cyp46a1 has several biochemical functions, for example, cholesterol 24-hydroxylase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cyp46a1 itself. We selected most functions cyp46a1 had, and list some proteins which have the same functions with cyp46a1. You can find most of the proteins on our site.

    Function Related Protein
    cholesterol 24-hydroxylase activity CYP46A1.2; CYP46A1.3; CYP46A1; CYP46A1.4
    heme binding CYP4A14; NOS1; CYP3C1L2; HBBE3; CYP2H1; HEBP1; CYP4B1; CYP4F22; CYP27C1; CYP2AA12
    iron ion binding ALOX15B; CYP1A2; HBZ; HBBE3; CYP3A4; MSMO1; NDOR1; CYP2AA4; PLOD3; CYP2K17
    steroid hydroxylase activity CYP1A1; CYP2S1; CYP2AA3; CYP2E1; CYP2A13; CYP2C38; CYP2AD6; CYP2J5; CYP2P9; CYP2C55

    cyp46a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cyp46a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of cyp46a1.


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