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Official Full Name cytochrome P450, family 4, subfamily F, polypeptide 2
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F11, is approximately 16 kb away.
Synonyms CYP4F2; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 2; leukotriene-B(4) omega-hydroxylase 1; CYPIVF2; cytochrome P450 4F2; cytochrome P450-LTB-omega; leukotriene-B4 20-monooxygenase; leukotriene B4 om
    • Species :
    • Human
    • Source :
    • E. coli
    • E.coli
    • Insect Cell
    • Tag :
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP4F2-10H Recombinant Human CYP4F2 Protein E.coli
    Human CYP4F2-85H Recombinant Human CYP4F2 Protein E. coli
    Human CYP4F2-555H Recombinant Human CYP4F2 Insect Cell N/A

    cyp4f2 involved in several pathways and played different roles in them. We selected most pathways cyp4f2 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with cyp4f2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Arachidonic acid metabolism ALOX8; GGT5; CBR1L; CYP1B1; FAM213B; PLA2G4AA; CYP4F18; ALOX12B; PLA2G2A; AKR1C6
    Metabolic pathways MVK; ITGB1BP3; P4HA1B; RDH12; PGM1; GALNT12; POLR1E; ATP6V1C1; ACSS3; GLCEB

    cyp4f2 has several biochemical functions, for example, alkane 1-monooxygenase activity, alpha-tocopherol omega-hydroxylase activity, arachidonic acid epoxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cyp4f2 itself. We selected most functions cyp4f2 had, and list some proteins which have the same functions with cyp4f2. You can find most of the proteins on our site.

    Function Related Protein
    alkane 1-monooxygenase activity CYP4A14; CYP4F2; CYP4F18; CYP4F12; CYP4A12A; CYP4A11; CYP4A10
    alpha-tocopherol omega-hydroxylase activity CYP4F2; CYP4F3; CYP4F18; CYP4F14
    arachidonic acid epoxygenase activity CYP2N13; CYP2B19; CYP2C38; CYP2C54; CYP2AA4; CYP2V1; CYP2AD3; CYP2F1; CYP2AA7; CYP2P9
    arachidonic acid omega-hydroxylase activity CYP4F2; CYP4A10; CYP4F18; CYP4A14
    heme binding CYP46A1.3; MFSD7C; NENF; CYB5B; CYP2F1; CYP2P6; CYP4V8; CYP2X10.2; CYB5R4; PXDN
    iron ion binding CYP46A1; CYP1A4; CYP4Z1; CYP2X8; CYP11C1; CYP2C37; P4HA3; CYP3A43; CYP2AA7; CYP2J2
    leukotriene-B4 20-monooxygenase activity CYP4F18; CYP4F12; CYP4A11; CYP4A10; CYP4F14; CYP4F2; CYP4F3
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen MICAL2; CYP11B1; MICAL1; COQ6; CYP4F18; CYP2E1; CYP11C1; POR; CYP11B2; CYP4F2
    protein binding NR4A3; HIST1H2BE; DYNLT1; MED7; DBC1; NDUFAF4; ATRX; RAB35; PQBP1; ICAM1
    tocotrienol omega-hydroxylase activity CYP4F18; MICAL2; CYP4F2; MICAL2B

    cyp4f2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cyp4f2 here. Most of them are supplied by our site. Hope this information will be useful for your research of cyp4f2.

    ABL1; FYN; SRC; NCK1; GRB2

    Uehara, S; Murayama, N; et al. Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine. XENOBIOTICA 45:124-130(2015).
    Michaels, S; Wang, MZ; et al. The Revised Human Liver Cytochrome P450 "Pie": Absolute Protein Quantification of CYP4F and CYP3A Enzymes Using Targeted Quantitative Proteomics. DRUG METABOLISM AND DISPOSITION 42:1241-1251(2014).

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