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CYP4F22

Official Full Name

cytochrome P450, family 4, subfamily F, polypeptide 22
Overview

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3.
Synonyms

CYP4F22; cytochrome P450, family 4, subfamily F, polypeptide 22; cytochrome P450 4F22; FLJ39501; CP4FN_HUMAN; FLJ 39501; LI3; cytochrome P450, family 2, subfamily E, polypeptide 2 homolog;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Rhesus Macaque

Source

HEK293
HEK293T
In Vitro Cell Free System
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
Myc
DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CYP4F22-2284H	Recombinant Human CYP4F22 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	CYP4F22-7101HCL	Recombinant Human CYP4F22 293 Cell Lysate	HEK293	N/A		Inquiry
Human	CYP4F22-2444HF	Recombinant Full Length Human CYP4F22 Protein, GST-tagged	In Vitro Cell Free System	GST	531 amino acids	Inquiry
Human	CYP4F22-5879H	Recombinant Human CYP4F22 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Rhesus Macaque	CYP4F22-1163R	Recombinant Rhesus monkey CYP4F22 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	CYP4F22-988R	Recombinant Rhesus Macaque CYP4F22 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	CYP4F22-988R-B	Recombinant Rhesus Macaque CYP4F22 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

CYP4F22 involved in several pathways and played different roles in them. We selected most pathways CYP4F22 participated on our site, such as Arachidonic acid metabolism, Biological oxidations, Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Arachidonic acid metabolism	CYP2C50;TBXAS1;CYP4F14;HPGDS;PTGS1;PLA2G4F;PLA2G4AA;PLA2G4A;GPX6
Biological oxidations	ADH1B;POMCB;CYP2D6;CYP2AD6;CYP2F1;SULT1ST6;ABHD10;CYP7A1;CYP2C19
Cytochrome P450 - arranged by substrate type	CYP2S1;FDX1L;CYP2K22;CYP2A13;FAM84B;FDXR;CYP4B1;CYP21A2;CYP2B6
Eicosanoids	CYP4B1;CYP4F12;CYP4F11;CYP4F22;CYP4A11
Fatty acids	CYP2D6;CYP2J2;CYP2V1;CYP2A13;CYP2A7;CYP4F12;CYP2F1;CYP4T8;CYP4A11
Metabolism	ETFA;NUDT3A;ARL2BP;LYPLA1;GLIPR1;AZIN2;CYP3A7-CYP3AP1;CLPS;BPNT1
Metabolism of lipids and lipoproteins	APOA4B.2;CYP2AD6;CTGF;MED9;APOBB.1;ABHD4;PIK3R6;MED8;APOA4B.1
Miscellaneous substrates	CYP2K22;CYP3C1;CYP2W1;CYP4F22;CYP2K8;CYP2K19;CYP2U1;CYP4B1;CYP3C4

CYP4F22 has several biochemical functions, for example, heme binding, iron ion binding, monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F22 itself. We selected most functions CYP4F22 had, and list some proteins which have the same functions with CYP4F22. You can find most of the proteins on our site.

Function	Related Protein
heme binding	AMBP;IDO1;CYP46A1.1;CYGB1;CYP4A10;PTGESL;CYP2D6;CYP4F12;CYP4V7
iron ion binding	CYP4V8;CYP2AA8;HBA1;TYW5;CYP51A1;CYP2AD2;OGFOD2;ALOX12E;CYP17A2
monooxygenase activity	CYP4A14;CYP1A4;CYP2C38;CYP2AA4;CYP2C9;CYP2D6;CYP3A4;CYP19A1B;CYP4V2
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	CYP4V2;CYP3C1L2;CYP2C50;CYP26C1;CYP2D10;CYP2F2;P4HA1B;CYP4A10;CYP4V8

CYP4F22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F22.