CYP4F22

  • Official Full Name

    cytochrome P450, family 4, subfamily F, polypeptide 22

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 19 and encodes an enzyme thought to play a role in the 12(R)-lipoxygenase pathway. Mutations in this gene are the cause of ichthyosis lamellar type 3.

  • Synonyms

    CYP4F22;cytochrome P450, family 4, subfamily F, polypeptide 22;cytochrome P450 4F22;FLJ39501;CP4FN_HUMAN;FLJ 39501;LI3;cytochrome P450, family 2, subfamily E, polypeptide 2 homolog

Recombinant Proteins

  • Rhesus macaque
  • Human
  • Mammalian Cells
  • Wheat Germ
  • HEK293
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • DDK
  • Myc
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
CYP4F22-1163R Recombinant Rhesus monkey CYP4F22 Protein, His-tagged Mammalian Cells Rhesus macaque His
CYP4F22-2284H Recombinant Human CYP4F22 Protein, GST-tagged Wheat Germ Human GST
CYP4F22-7101HCL Recombinant Human CYP4F22 293 Cell Lysate HEK293 Human Non
CYP4F22-2444HF Recombinant Full Length Human CYP4F22 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 531 amino acids
CYP4F22-5879H Recombinant Human CYP4F22 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
CYP4F22-988R Recombinant Rhesus Macaque CYP4F22 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
CYP4F22-988R-B Recombinant Rhesus Macaque CYP4F22 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    CYP4F22 involved in several pathways and played different roles in them. We selected most pathways CYP4F22 participated on our site, such as Arachidonic acid metabolism,Biological oxidations,Cytochrome P450 - arranged by substrate type, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP4F22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Biological oxidations SULT1C2,SULT1ST5,AADAC,CYP11A1,AS3MT,CYP2C19,SULT1ST6,GGTLC1,CYP2C18,UGT1B7
    Eicosanoids CYP4F12,CYP4B1,CYP4A11,CYP4F11
    Cytochrome P450 - arranged by substrate type CYP27A1,CYP11B2,CYP2K16,CYP2R1,CYP24A1,CYP1A1,CYP2C8,CYP2V1,CYP2K8,CYP17A1
    Metabolism LMF2,NUDT3A,MED7,DBH,AK7A,ATP5S,SLC52A3,YAP1,NAGS,UGT1B3
    Arachidonic acid metabolism CYP1A1,ALOX8,AWAT2,CYP2V1,HPGDS,CYP2C38,ALOX15,TBXAS1,CYP2E1,CYP2C50
    Metabolism of lipids and lipoproteins ACOT9,MED7,ABHD4,ARF3,MTP,APOEA,AKR1C21,SLC25A1,APOA5,PIK3R6
    Fatty acids CYP2F1,CYP4B1,CYP2D6,CYP4F11,CYP2N13,CYP2B6,CYP4A11,CYP2A13,CYP2AD3,CYP4F12
    Miscellaneous substrates CYP2K6,CYP2K18,CYP2K17,CYP2K16,CYP2U1,CYP2K8,CYP3C4,CYP4B1,CYP2S1,CYP2W1

    Protein Function

    CYP4F22 has several biochemical functions, for example, heme binding,iron ion binding,monooxygenase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP4F22 itself. We selected most functions CYP4F22 had, and list some proteins which have the same functions with CYP4F22. You can find most of the proteins on our site.

    Function Related Protein
    monooxygenase activity CYP27C1,CYP1B1,CYP3A5,CYP3A43,CYP4T8,TYR,CYP2AD6,CYP2K6,CYP2D6,CYP3C1L2
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen CYP2D26,CYP17A2,CYP46A1.1,P4HA1A,CYP2D10,CYP2C55,CYP19A1A,CYP2AA9,CYP2P9,CYP46A1.2
    iron ion binding CYP11A1,CYP2E1,CYP3A5,CYP51,CYP8B2,CYP4F3,CYP3A4,TPH1B,FTH1,CYP4F14
    heme binding CYP26C1,CYP17A1,CYP2X8,JAK2,CYP2AA9,CYP2W1,CYP2AA1,CYP2AA2,CYP2K19,CYP11A1

    Interacting Protein

    CYP4F22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP4F22 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP4F22.

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