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Official Full Name CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 [ Homo sapiens ]
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms CP51; CP51A_HUMAN; CYP51; CYP51A1; CYPLI; Cytochrome P450 51; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Lanosterol 14-alpha demethylase; LDM; P450 14DM; P450L1; Sterol 14-alpha demethylase
    • Species :
    • Chicken
    • Human
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP51A1-11794H Recombinant Human CYP51A1, GST-tagged E.coli GST
    Human CYP51A1-1580H Recombinant Human CYP51A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CYP51A1-2290H Recombinant Human CYP51A1 Protein, GST-tagged Wheat Germ GST
    Human CYP51A1-7100HCL Recombinant Human CYP51A1 293 Cell Lysate HEK293 N/A
    Chicken CYP51A1-3505C Recombinant Chicken CYP51A1 Mammalian Cell His

    cyp51a1 involved in several pathways and played different roles in them. We selected most pathways cyp51a1 participated on our site, such as Activation of gene expression by SREBF (SREBP), Biological oxidations, Biosynthesis of antibiotics, which may be useful for your reference. Also, other proteins which involved in the same pathway with cyp51a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of gene expression by SREBF (SREBP) PMVK; CREBBP; CARM1; HELZ2; CYP51A1; SREBF2; NFYBB; NFYBA; NCOA2; MTF1
    Biological oxidations CYP4B1; CES1; ACY3; ADH6; CYP1A2; UGT1B1; PRKRA; Sult2a2; CYP2AD2; ADH8B
    Biosynthesis of antibiotics CTH; ANI_1_2390104; LDHAL6A; ADH5; AMDHD2; CS; ACAA2; SDS; pykF; BPNT1
    Cholesterol biosynthesis ARV1; PMVK; SREBF2; CYP51A1; DHCR7; EBP; DHCR24; LBR
    Cytochrome P450 - arranged by substrate type CYP17A1; CYP2F1; FDX1; CYP2K8; CYP3A5; CYP4F11; CYP2AD2; CYP2K17; CYP46A1; CYP2A6
    Endogenous sterols CYP11A1; POMCB; CYP46A1; FDX1L; CYP11B1; CYP27A1; CYP11B2; CYP51A1; CYP17A1; CYP8B2
    Metabolic pathways NME2B.1; FUT8; GLCEA; MGAT4A; H2-KE6; AGPS; DAD1; GALNT11; FTCD; PCK1
    Metabolism Agmo; APOEB; MED16; PDK4; PPM1LA; PPM1L; ARSI; MED29; NAMPT; SULT1C2

    cyp51a1 has several biochemical functions, for example, heme binding, iron ion binding, sterol 14-demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cyp51a1 itself. We selected most functions cyp51a1 had, and list some proteins which have the same functions with cyp51a1. You can find most of the proteins on our site.

    Function Related Protein
    heme binding MPO; CYP4T8; CYP2A4; CYP2C38; SDHC; NOX4; NOS1; HBAD; CYP4V7; BA1
    iron ion binding CYP2K22; CYP2X10.2; ALOX5B.3; TPH1A; CYP4F11; TMLHE; CYP1C1; CYP2A13; CYP1B1; FDX1
    sterol 14-demethylase activity CYP51; CYP51A1

    cyp51a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cyp51a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of cyp51a1.

    ETS1; ZNF420; 1C

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