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CYP51A1

  • Official Full Name

    CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 [ Homo sapiens ]

  • Overview

    This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, plants, and animals, suggesting that this is one of the oldest cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    CP51; CP51A_HUMAN; CYP51; CYP51A1; CYPLI; Cytochrome P450 51; Cytochrome P450 51A1; Cytochrome P450-14DM; Cytochrome P45014DM; Cytochrome P450LI; Lanosterol 14-alpha demethylase; LDM; P450 14DM; P450L1; Sterol 14-alpha demethylase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
  • Mus musculus (Mouse)
  • Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
  • Rattus norvegicus (Rat)
  • Sus scrofa (Pig)
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CYP51A1-11794H Recombinant Human CYP51A1, GST-tagged E.coli GST 146-509a.a.
Human CYP51A1-2290H Recombinant Human CYP51A1 Protein, GST-tagged Wheat Germ GST
Human CYP51A1-7100HCL Recombinant Human CYP51A1 293 Cell Lysate HEK293 N/A
Human CYP51A1-1748HFL Recombinant Full Length Human CYP51A1 Protein, C-Flag-tagged Mammalian cells Flag
Human CYP51A1-707H-B Recombinant Human CYP51A1 Protein Pre-coupled Magnetic Beads HEK293
Human CYP51A1-707H Recombinant Human CYP51A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CYP51A1-1580H Recombinant Human CYP51A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Bos taurus (Bovine) RFL10948BF Recombinant Full Length Bovine Lanosterol 14-Alpha Demethylase(Cyp51A1) Protein, His-Tagged E.coli expression system His Full Length (1-502)
Homo sapiens (Human) RFL7658HF Recombinant Full Length Human Lanosterol 14-Alpha Demethylase(Cyp51A1) Protein, His-Tagged E.coli expression system His Full Length (1-503)
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) RFL35269MF Recombinant Full Length Macaca Fascicularis Lanosterol 14-Alpha Demethylase(Cyp51A1) Protein, His-Tagged E.coli expression system His Full Length (1-503)
Mus musculus (Mouse) RFL27609MF Recombinant Full Length Mouse Lanosterol 14-Alpha Demethylase(Cyp51A1) Protein, His-Tagged E.coli expression system His Full Length (1-503)
Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) RFL23172PF Recombinant Full Length Pongo Abelii Lanosterol 14-Alpha Demethylase(Cyp51A1) Protein, His-Tagged E.coli expression system His Full Length (1-503)
Rattus norvegicus (Rat) RFL23164RF Recombinant Full Length Rat Lanosterol 14-Alpha Demethylase(Cyp51A1) Protein, His-Tagged E.coli expression system His Full Length (1-503)
Sus scrofa (Pig) RFL32136SF Recombinant Full Length Pig Lanosterol 14-Alpha Demethylase(Cyp51A1) Protein, His-Tagged E.coli expression system His Full Length (1-503)
Chicken CYP51A1-3505C Recombinant Chicken CYP51A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CYP51A1 involved in several pathways and played different roles in them. We selected most pathways CYP51A1 participated on our site, such as Activation of gene expression by SREBF (SREBP), Biological oxidations, Biosynthesis of antibiotics, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP51A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of gene expression by SREBF (SREBP)CYP51A1;NCOA2;DHCR7;MTF1;SREBF2;HELZ2;NFYBB;NFYBA;PMVK
Biological oxidationsCYP2A13;CYP2C9;CYP27B1;NCOA2;SULT2ST2;ACY3;ADH1B;SULT1ST5;ADH4
Biosynthesis of antibioticsPAICS;SDS;ADSL;DAO;LDHAL6A;GLYCTK;CMBL;LDHAL6B;UAP1L1
Cholesterol biosynthesisDHCR24;PMVK;DHCR7;CYP51A1;LBR;ARV1;SREBF2;EBP
Cytochrome P450 - arranged by substrate typeCYP2S1;CYP2K6;CYP2AD3;CYP2A13;CYP21A2;CYP2N13;CYP3A5;CYP2Y3;CYP2W1
Endogenous sterolsCYP11B2;CYP7A1;CYP11A1;CYP51A1;CYP46A1;POMCB;CYP17A1;CYP11B1;CYP21A2
Metabolic pathwaysMINPP1A;BCO1L;SCP2A;NAGLU;AGK;SMPD2;CYP2P9;ACADVL;SPTLC1
MetabolismAK7;KIAA1199;CYP51A1;SLC25A10;SLC5A2;CYP2A7;ACOT10;APOF;PNP5B

CYP51A1 has several biochemical functions, for example, heme binding, iron ion binding, sterol 14-demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP51A1 itself. We selected most functions CYP51A1 had, and list some proteins which have the same functions with CYP51A1. You can find most of the proteins on our site.

Function Related Protein
heme bindingCYP26C1;CYP2B6;CYP2K19;CYP2AD6;PTGESL;NOS1;CBSA;CYP21A1;HBB-B2
iron ion bindingALOX15;CYP4A11;LTF;CYP2P6;CYP46A1.3;BBOX1;ALOX12B;CYP4T8;NOS2
sterol 14-demethylase activityCYP51;CYP51A1

CYP51A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP51A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP51A1.

ETS1; ZNF420; 1C

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