CYP7B1

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CYP7B1

Official Full Name cytochrome P450, family 7, subfamily B, polypeptide 1
Background This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids. This enzyme likely plays a minor role in total bile acid synthesis, but may also be involved in the development of atherosclerosis, neurosteroid metabolism and sex hormone synthesis.
Synonyms CYP7B1; cytochrome P450, family 7, subfamily B, polypeptide 1; cytochrome P450, subfamily VIIB (oxysterol 7 alpha hydroxylase), polypeptide 1 , spastic paraplegia 5A (autosomal recessive) , SPG5A; 25-hydroxycholesterol 7-alpha-hydroxylase; cytochrome P45
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CYP7B1-2292H Recombinant Human CYP7B1 Protein, GST-tagged Wheat Germ GST
    Human CYP7B1-7098HCL Recombinant Human CYP7B1 293 Cell Lysate HEK293 N/A
    Mouse Cyp7b1-2426M Recombinant Mouse Cyp7b1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat CYP7B1-1758R Recombinant Rat CYP7B1 Protein Mammalian Cell His

    CYP7B1 involved in several pathways and played different roles in them. We selected most pathways CYP7B1 participated on our site, such as Primary bile acid biosynthesis, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP7B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Primary bile acid biosynthesis ACOX2; CH25HL2; CYP46A1.1; CH25HL1.2; BAAT; CYP7A1A; AKR1C4; CH25H; SLC27A5; AMACR
    Steroid hormone biosynthesis HSD17B3; CYP19A1A; AKR1D1; UGT1A1; COMTA; HSD17B12B; CYP2C50; CYP2D9; H2-KE6; HSD17B12A

    CYP7B1 has several biochemical functions, for example, 25-hydroxycholesterol 7alpha-hydroxylase activity, heme binding, iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP7B1 itself. We selected most functions CYP7B1 had, and list some proteins which have the same functions with CYP7B1. You can find most of the proteins on our site.

    Function Related Protein
    25-hydroxycholesterol 7alpha-hydroxylase activity CYP7B1
    heme binding CYP1A1; CYP20A1; CYP2V1; CYP11A1; CYP2X7; CYP8B1; JAK2; CYP2F1; NOX5; FA2H
    iron ion binding CYP2C55; Agmo; TMLHE; CYP2V1; PLOD2; P4HA3; SC5D; CYP4F22; PTGIS; HBBE2
    oxysterol 7-alpha-hydroxylase activity CYP7B1

    CYP7B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP7B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP7B1.

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