dapk1
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  • Official Full Name
  • death-associated protein kinase 1
  • Background
  • Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate.
  • Synonyms
  • DAPK1; death-associated protein kinase 1; DAPK; DAP kinase 1; DKFZp781I035
Cat.#:DAPK1-2335HTag:GST/His
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant HumanPK1 DAPK1 Protein, GST-His-tagged
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Cat.#:DAPK1-2336HTag:His
Source (Host):Insect CellsSpecies:Human
Product nameRecombinant Human DAPK1 Protein, His-tagged
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Cat.#:DAPK1-2337HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DAPK1 Protein, GST-tagged
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Cat.#:DAPK1-985HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human DAPK1 Protein, MYC/DDK-tagged
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Cat.#:DAPK1-11825HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DAPK1, GST-tagged
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Cat.#:DAPK1-27363THTag:
Source (Host):Species:Human
Product nameRecombinant Human DAPK1
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Cat.#:DAPK1-289HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DAPK1, GST-tagged, Active
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Cat.#:DAPK1-971HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DAPK1, His & GST tagged
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Cat.#:DAPK1-4304MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DAPK1 Protein
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Cat.#:DAPK1-1176RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey DAPK1 Protein, His-tagged
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Cat.#:DAPK1-3251CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DAPK1
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Cat.#:DAPK1-5801ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DAPK1
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Cat.#:DAPK1-1395HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human DAPK1 (Active), GST-tagged
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Cat.#:DAPK1-602HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human DAPK1 cell lysate
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Involved Pathway

DAPK1 involved in several pathways and played different roles in them. We selected most pathways DAPK1 participated on our site, such as Apoptosis, Bladder cancer, Caspase activation via extrinsic apoptotic signalig pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAPK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Apoptosis
CRADD; DERL3; Gzmg; IRF6; NGF; AKT2L; IKBKG; PIK3R5; CASP9; CASP3B
Bladder cancer
DAPK1; RAF1; KRAS; HBEGF; MMP1A; MAPK3; TP53; MAP2K1; IL-8; RB1
Caspase activation via extrinsic apoptotic signalig pathway
TICAM1; DAPK3; DCC; RNF8; DAPK1; CASP8L1
IFN-gamma pathway
DAPK1; IRF9
Ligand-independent caspase activation via DCC
DAPK1; DAPK3; RNF8
Pathways in cancer
CSF1R; TCF7L2; TCF7; PTCH1; GNB3; FGF13; TGFBR1; EGLN2; FGF12; GNAI3
Programmed Cell Death
DIABLOB; VIML; GZMF; PKP1; BMX; HMGB2A; PANK1A; GAS2; SATB1; CASP6L1

Protein Function

DAPK1 has several biochemical functions, for example, ATP binding, GTP binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DAPK1 itself. We selected most functions DAPK1 had, and list some proteins which have the same functions with DAPK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SMC5; PDIK1L; YES1; DHX34; ADRBK2; PLK1; INSRR; BMPR1BB; PRPF4BB; ROCK2A
Function GTP binding
Related Protein TUBG2; GTPBP1; TUBA1C; ARL10; TUBA8L3; AK3; ARF4B; RAB32; RAB6C; EEF1A1A
Function calmodulin binding
Related Protein RASGRF2; PDE1A; PCDP1; CAMK1GA; SLC14A2; EPB41; MYH1E; CALD1B; GM101; CAMKV
Function calmodulin-dependent protein kinase activity
Related Protein CAMK2B; MAPKAPK2; CAMK2B1; MKNK2B; CAMK2A; CAMK2G1; CAMK2D; DCX; CAMKK2; PTK2B
Function identical protein binding
Related Protein HAPLN2; ATXN3; DCP1A; HTT; DIAP1; DIAPH1; TFRC; PDGFB; VIM; IFI16
Function protein binding
Related Protein URM1; PPP4R1; ATP6V1E2; REEP6; GLA; RECQL4; JUND; PLSCR1; RAB6B; BTN3A1
Function protein kinase activity
Related Protein GSG2; MAP2K1; TEX14; DCLK3; SRPK1; DYRK1A; STK3; AKT3A; INSRB; AKT1
Function protein serine/threonine kinase activity
Related Protein PKMYT1; BMPR1AB; BCR; STK35; BSK146; CAMK1DB; CLK3; PDIK1L; CDK11B; BMPR2A
Function syntaxin-1 binding
Related Protein GOLSYN; STXBP3A; SYBU; NSF; SNPH; SNAP25; STXBP1; VAMP3; SNAP25A; MYO5A

Interacting Protein

DAPK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAPK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAPK1.
N/A; KLHL20; MAPK3

DAPK1 Related Articles

Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014).
Jin, XH; Wu, XX; et al. Delineation of apoptotic genes for synergistic apoptosis of lexatumumab and anthracyclines in human renal cell carcinoma cells by polymerase chain reaction array. ANTI-CANCER DRUGS 23:445-454(2012).