DCLRE1C
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Official Full Name
DNA cross-link repair 1C
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Overview
This gene encodes a nuclear protein that is involved in V(D)J recombination and DNA repair. The encoded protein has single-strand-specific 5-3 exonuclease activity; it also exhibits endonuclease activity on 5 and 3 overhangs and hairpins. The protein also functions in the regulation of the cell cycle in response to DNA damage. Mutations in this gene can cause Athabascan-type severe combined immunodeficiency (SCIDA) and Omenn syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] -
Synonyms
DCLRE1C; DNA cross-link repair 1C; SCIDA; SNM1C; A-SCID; RS-SCID; DCLREC1C; protein artemis; SNM1 homolog C; SNM1-like protein; severe combined immunodeficiency, type a (Athabascan); DNA cross-link repair 1C (PSO2 homolog, S. cerevisiae);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | DCLRE1C-2396H | Recombinant Human DCLRE1C Protein, GST-tagged | Wheat Germ | GST | ||
Human | DCLRE1C-7049HCL | Recombinant Human DCLRE1C 293 Cell Lysate | HEK293 | N/A | ||
Human | DCLRE1C-2932H | Recombinant Human DCLRE1C protein, His-tagged | E.coli | His | 305-577 aa | |
Human | DCLRE1C-2881HF | Recombinant Full Length Human DCLRE1C Protein, GST-tagged | In Vitro Cell Free System | GST | 434 amino acids | |
Rat | DCLRE1C-1796R | Recombinant Rat DCLRE1C Protein | Mammalian Cell | His | ||
Rat | DCLRE1C-1454R-B | Recombinant Rat DCLRE1C Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | DCLRE1C-1454R | Recombinant Rat DCLRE1C Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus Macaque | DCLRE1C-1192R | Recombinant Rhesus monkey DCLRE1C Protein, His-tagged | Mammalian Cell | His | ||
Rhesus Macaque | DCLRE1C-1017R-B | Recombinant Rhesus Macaque DCLRE1C Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rhesus Macaque | DCLRE1C-1017R | Recombinant Rhesus Macaque DCLRE1C Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Zebrafish | DCLRE1C-4147Z | Recombinant Zebrafish DCLRE1C | Mammalian Cell | His | ||
Chicken | DCLRE1C-3234C | Recombinant Chicken DCLRE1C | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
DCLRE1C involved in several pathways and played different roles in them. We selected most pathways DCLRE1C participated on our site, such as Non-homologous end-joining, Primary i, nodeficiency, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCLRE1C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Non-homologous end-joining | XRCC4;DNTT;DCLRE1C;FEN1;PRKDC;LIG4;POLL;XRCC5;XRCC6 |
Primary i | CD8B1;IKBKG;RAG1;CD4;AICDA;CD8B;PTPRC;ZAP70;CD40LG |
nodeficiency | ICOS;TAP2;Cd79a, Cd79b;AIRE;BLNK;ZAP70;PTPRC;RFXANK;LCK |
DCLRE1C has several biochemical functions, for example, 5-3 exodeoxyribonuclease activity, 5-3 exonuclease activity, damaged DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCLRE1C itself. We selected most functions DCLRE1C had, and list some proteins which have the same functions with DCLRE1C. You can find most of the proteins on our site.
Function | Related Protein |
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5-3 exodeoxyribonuclease activity | DCLRE1A;DCLRE1C;EXO1 |
5-3 exonuclease activity | DOM3Z;FEN1;CPSF3;DXO;XRN2;POLN;DCLRE1C;EXO1;FAN1 |
damaged DNA binding | NEIL2;HMGB2;NEIL3;POLK;UNG;RPS3;POLB;XPC;RAD1 |
endonuclease activity | ANG3;DCLRE1C;FEN1;G3BP1;EME1;DNASE1L3L;CENPT;ANG;SETMAR |
protein binding | ACTN1;CASP6;HMGA1;C19orf60;WHRN;TPRGL;OSBP2;PRKG1;FAM9C |
single-stranded DNA endodeoxyribonuclease activity | SETMAR;DCLRE1C;MRE11A;ERCC4;RBBP8 |
DCLRE1C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCLRE1C here. Most of them are supplied by our site. Hope this information will be useful for your research of DCLRE1C.
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