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Official Full Name dopa decarboxylase (aromatic L-amino acid decarboxylase)
Background The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine,;L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic;L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that;leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding;different isoforms have been identified for this gene.
Synonyms DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase); aromatic-L-amino-acid decarboxylase; AADC
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Rabbit
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • T7
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDC-01H Recombinant Human DDC Protein, His-tagged E.coli His
    Human CAB11523RH Rabbit Anti-Human Dopa Decarboxylase Monoclonal Antibody Rabbit N/A
    Human DDC-141H Recombinant Human Dopa Decarboxylase, His-tagged E.coli His
    Human DDC-223H Recombinant Human DDC Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DDC-2433H Recombinant Human DDC Protein, GST-tagged Wheat Germ GST
    Human DDC-26888TH Recombinant Human DDC, His-tagged E.coli His
    Human DDC-28085TH Recombinant Human DDC E.coli N/A
    Human DDC-284H Recombinant Human DDC, His tagged Insect Cell His
    Human DDC-3118H Recombinant Human DDC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human DDC-491H Recombinant Human DDC Protein, His-tagged E.coli His
    Human DDC-724HCL Recombinant Human DDC cell lysate Insect Cell N/A
    Human DDC-848H Recombinant Human DDC, T7-tagged E.coli T7
    Human DDC-915H Recombinant Human DDC Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Ddc-2490M Recombinant Mouse Ddc Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Ddc-2510M Recombinant Mouse Dopa Decarboxylase, His-tagged E.coli His
    Mouse DDC-513MCL Recombinant Mouse DDC cell lysate Insect Cell N/A
    Mouse DDC-915M Recombinant Mouse DDC Protein, His-tagged Insect Cell His
    Rat Ddc-3638R Recombinant Rat Ddc, His-tagged E.Coli or Yeast His
    Zebrafish DDC-12525Z Recombinant Zebrafish DDC Mammalian Cell His

    DDC involved in several pathways and played different roles in them. We selected most pathways DDC participated on our site, such as Alcoholism, Amine-derived hormones, Biogenic Amine Synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amine-derived hormones DIO2; CGA; DDC; TPH2; DBH
    Biogenic Amine Synthesis COMT; DDC; DBH; CHAT
    Catecholamine biosynthesis MOXD2; DDC; DBH
    Cocaine addiction GRM3; DLG4; FOSB; GRIN2D; GRIN2B; CDK5; GRIN1; PRKACB; GNAI3; SLC18A1
    Dopamine metabolism DDC; NQO1; COMT
    Dopaminergic synapse PPP2R2D; FOS; DRD3; ITPR1; SLC6A3; GNG13; SLC18A2; DDC; KCNJ6; DRD1

    DDC has several biochemical functions, for example, L-dopa decarboxylase activity, amino acid binding, aromatic-L-amino-acid decarboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDC itself. We selected most functions DDC had, and list some proteins which have the same functions with DDC. You can find most of the proteins on our site.

    Function Related Protein
    L-dopa decarboxylase activity DDC
    amino acid binding GCHFR; TPH1A; TPH2; DDAH2; TDO2; DDC; TAT; TH; AARS; DDAH1
    aromatic-L-amino-acid decarboxylase activity DDC
    enzyme binding PTPN1; UGT1A9; TH; CAV1; DNM2; IQCB1; MAT2B; AKT1; HDAC3; RCOR2
    protein binding CORO6; ALKBH3; TDP2; ADRB2; CD200; USP22; RUVBL1; VRK2; SERPINF2; C4orf26
    protein domain specific binding MYO1D; EZR; ARFIP2A; IRS2; TFDP1; RUNX2; YWHAQ; MPP5; SP100; CACNB2
    pyridoxal phosphate binding AGXT2; SPTLC3; PDXK; ABAT; LOC650128; SDS; AGXT; GPT2L; GAD1; SPTLC2B

    DDC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDC here. Most of them are supplied by our site. Hope this information will be useful for your research of DDC.

    AR; Ar; ATF6; RELA

    Pi, LY; Robinson, PM; et al. Connective Tissue Growth Factor and Integrin alpha v beta 6: A New Pair of Regulators Critical for Ductular Reaction and Biliary Fibrosis in Mice. HEPATOLOGY 61:678-691(2015).
    Yoshida, S; Ikenaga, N; et al. Extrahepatic Platelet-Derived Growth Factor-beta, Delivered by Platelets, Promotes Activation of Hepatic Stellate Cells and Biliary Fibrosis in Mice. GASTROENTEROLOGY 147:1378-1392(2014).

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