Recombinant Full Length Human DDC Protein, GST-tagged

• Cat.No.: DDC-2428HF
• Product Overview: Human DDC full-length ORF ( AAH08366, 1 a.a. - 480 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2011]
• Source: In Vitro Cell Free System
• Species: Human
• Tag: GST
• Molecular Mass: 78.43 kDa
• Protein Length: 480 amino acids
• AA Sequence: MNASEFRRRGKEMVDYVANYMEGIE GRQVYPDVEPGYLRPLIPAAAPQEP DTFEDIINDVEKIIMPGVTHWHSPY FFAYFPTASSYPAMLADMLCGAIGC IGFSWAASPACTELETVMMDWLGKM LELPKAFLNEKAGEGGGVIQGSASE ATLVALLAARTKVIHRLQAASPELT QAAIMEKLVAYSSDQAHSSVERAGL IGGVKLKAIPSDGNFAMRASALQEA LERDKAAGLIPFFMVATLGTTTCCS FDNLLEVGPICNKEDIWLHVDAAYA GSAFICPEFRHLLNGVEFADSFNFN PHKWLLVNFDCSAMWVKKRTDLTGA FRLDPTYLKHSHQDSGLITDYRHWQ IPLGRRFRSLKMWFVFRMYGVKGLQ AYIRKHVQLSHEFESLVRQDPRFEI CVEVILGLVCFRLKGSNKVNEALLQ RINSAKKIHLVPCHLRDKFVLRFAI CSRTVESAHVQRAWEHIKELAADVL RAERE
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) [ Homo sapiens ]
• Official Symbol: DDC
• Synonyms: DDC; dopa decarboxylase (aromatic L-amino acid decarboxylase); aromatic-L-amino-acid decarboxylase; AADC
• Gene ID: 1644
• mRNA Refseq: NM_000790
• Protein Refseq: NP_000781
• MIM: 107930
• UniProt ID: P20711