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Official Full Name DNA-damage-inducible transcript 4
Background Inhibits cell growth by regulating the TOR signaling pathway upstream of the TSC1-TSC2 complex and downstream of AKT1. Promotes neuronal cell death.
Synonyms DDIT4; DNA-damage-inducible transcript 4; DNA damage-inducible transcript 4 protein; Dig2; FLJ20500; HIF 1 responsive RTP801; REDD 1; REDD1; RTP801; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801 (RTP801); protein regulated in development and DN
    • Species :
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDIT4-214H Recombinant Human DDIT4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DDIT4-2445H Recombinant Human DDIT4 Protein, GST-tagged Wheat Germ GST
    Human DDIT4-28311TH Recombinant Human DDIT4 E.coli N/A
    Human DDIT4-3433H Recombinant Human DDIT4 protein, His-tagged E.coli His
    Human DDIT4-7026HCL Recombinant Human DDIT4 293 Cell Lysate HEK293 N/A
    Human REDD1-2245H Recombinant Human REDD1 protein E.coli GST
    Mouse Ddit4-2493M Recombinant Mouse Ddit4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat DDIT4-1811R Recombinant Rat DDIT4 Protein Mammalian Cell His
    Rhesus Macaque DDIT4-1207R Recombinant Rhesus monkey DDIT4 Protein, His-tagged Mammalian Cell His
    Zebrafish DDIT4-10459Z Recombinant Zebrafish DDIT4 Mammalian Cell His

    DDIT4 involved in several pathways and played different roles in them. We selected most pathways DDIT4 participated on our site, such as mTOR signaling pathway, PIK-Akt signaling pathway, MicroRNAs in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with DDIT4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mTOR signaling pathway DEPDC6; STK11; AKT1S1; HIF1AB; PTEN; PRKCB; VEGFAA; PRKAA1; TSC1; PRKCG
    PIK-Akt signaling pathway FGF3; INS1; ITGA6; VWF; IFNA2; ITGB6; RPTOR; IFNA5; CREB3L3; IKBKG
    MicroRNAs in cancer CDC25C; SPRY2; RHOA; NOTCH3; BCL2L2; RDX; EFNA3; IRS1; MTOR; NRAS

    DDIT4 has several biochemical functions, for example, 14-3-3 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DDIT4 itself. We selected most functions DDIT4 had, and list some proteins which have the same functions with DDIT4. You can find most of the proteins on our site.

    Function Related Protein
    14-3-3 protein binding AANAT; PRKCZ; KIF13B; PPP1R12A; RPTOR; PRKCE; HDAC7; ZFP36; ARRB2; HDAC7A

    DDIT4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDIT4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDIT4.

    DDB1; BTRC; PDPK1; HSPA4; RIF1; q8czf9_yerpe; UBC; PLCG1; YWHAZ; CUL4A

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