|Official Full Name||DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11|
|Background||DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.|
|Synonyms||DDX11; DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 (S.cerevisiae CHL1 like helicase); probable ATP-dependent RNA helicase DDX11; CHL1; CHL1 like helicase|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
ddx11 involved in several pathways and played different roles in them. We selected most pathways ddx11 participated on our site, such as IRE1alpha activates chaperones, Metabolism of proteins, Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with ddx11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|IRE1alpha activates chaperones||C19orf10; SERP1; CXXC1; TPP1; WIPI1; ASNA1; PREB; KLHDC3; FKBP14; SEC61B|
|Metabolism of proteins||ST6GAL2B; CNIH; EID3; GRPEL2; MUC1; TOMM40; TBCA; FBXW5; CKAP4; MTX1|
|Unfolded Protein Response (UPR)||SERP1; CTDSP2; DDX11; WIPI1; TPP1; KLHDC3; C19orf10; DNAJB9; ASNA1; YIF1A|
|XBP1(S) activates chaperone genes||SEC63; PDIA6; CXXC1; YIF1A; DDX11; KLHDC3; HYOU1; C19orf10; WIPI1; DNAJB9|
ddx11 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ddx11 itself. We selected most functions ddx11 had, and list some proteins which have the same functions with ddx11. You can find most of the proteins on our site.
|4 iron, 4 sulfur cluster binding||DPYDB; RTEL1; ERCC2; NUBP2; DPYD; ACO2; BRIP1; NTHL1; LIAS; REV3L|
|ATP binding||PFKMA; YARS; CDK17; EPHB3A; NETO2; ABCB6; PIK3CB; ABCG2A; CASK; CLCN4|
|ATP-dependent DNA helicase activity||RUVBL2; DDX3X; ERCC2; RECQL; ERCC3; FBXO18; WRN; XRCC6; XRCC5; CHD2|
|DNA-dependent ATPase activity||ERCC2; CHD8; SMARCA4; SMARCA2; CHD6; RAD51C; XRCC2; RAD51B; CDK7; RAD51L1|
|RNA binding||EXOSC3; KHDC3L; TERT; AGO1; ADAD2; DNMT1; ZFP385C; PES; HNRNPA1; EIF4G2A|
|double-stranded DNA binding||ZNF638; SMAD2; TP53; DMC1; SETMAR; HMGB3; NEIL3; AFF3; HMGB2; IFI203|
|helicase activity||TDRD9; MCM3L; PL10; EIF4A2; GTF2F2A; PIF1; DHX33; DDX19; MCM6L; BAT1|
|metal ion binding||ZNF543; ZNF592; IRF2BP2B; NFS1; SCD5; METAP2A; EME1; AGBL4; NT5C; LHX8|
|protein binding||TUBA3C; GORAB; PEX11G; LAMTOR1; CYB5R1; KPNA3; CHAMP1; ZBTB22; UFL1; FCRL4|
|single-stranded DNA binding||SSBP4; NEIL3; CNBPA; IGHMBP2; SUB1; TREX1; RAD51; FBXO18; NABP1A; CTC1|
ddx11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ddx11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ddx11.