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DDX11

Official Full Name

DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Overview

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms

DDX11; DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 (S.cerevisiae CHL1 like helicase); probable ATP-dependent RNA helicase DDX11; CHL1; CHL1 like helicase;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
Mammalian Cell
Wheat Germ

Tag

GST
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DDX11-28322TH	Recombinant Human DDX11, GST-tagged	Wheat Germ	GST		Inquiry
Human	DDX11-11890H	Recombinant Human DDX11, GST-tagged	E.coli	GST	N-term-345a.a.	$319 / 25ug
Human	DDX11-454HCL	Recombinant Human DDX11 cell lysate		N/A		Inquiry
Mouse	DDX11-4399M	Recombinant Mouse DDX11 Protein	Mammalian Cell	His		Inquiry
Mouse	DDX11-2263M	Recombinant Mouse DDX11 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	DDX11-2263M-B	Recombinant Mouse DDX11 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	DDX11-1711Z	Recombinant Zebrafish DDX11	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
DDX11 Related Research Area

DDX11 involved in several pathways and played different roles in them. We selected most pathways DDX11 participated on our site, such as IRE1alpha activates chaperones, Metabolism of proteins, Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with DDX11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
IRE1alpha activates chaperones	PREB;HDGF;ADD1;C19orf10;WIPI1;HYOU1;PDIA6;KLHDC3;TPP1
Metabolism of proteins	ARSE;IGFBP5B;ADAMTS5;THSD7A;UBA2;MUC13;SFTPC;SPON1B;SEC16B
Unfolded Protein Response (UPR)	SERP1;SEC63;C19orf10;CXXC1;HDGF;CTDSP2;YY2;TPP1;DNAJB9
XBP1(S) activates chaperone genes	C19orf10;WIPI1;PDIA6;KDELR3;KLHDC3;CXXC1;TPP1;ASNA1;YIF1A

DDX11 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DDX11 itself. We selected most functions DDX11 had, and list some proteins which have the same functions with DDX11. You can find most of the proteins on our site.

Function	Related Protein
4 iron, 4 sulfur cluster binding	EXO5;TYW1B;REV3L;SDHB;DPYDB;DEM1;DNA2;NFU1;MUTYH
ATP binding	PANK4;HYOU1;BMP2K;NLRC4;NLRP14;TRMU;ACACB;EIF4A1A;MYO6
ATP-dependent DNA helicase activity	BLM;ERCC2;CHD1;CHD2;CHST13;XRCC6;RECQL;GTF2H4;CHD4
DNA-dependent ATPase activity	MSH3;SMARCA4;XRCC3;MSH5;MSH4;TOP2A;RAD51L1;DDX11;MSH6
RNA binding	U2SURP;EIF5A;RAVER1;AGFG1;PRPF6;SRSF3;DCP2;HNRNPH3;DUSP11
double-stranded DNA binding	ERCC5;TDP1;CRY1;MTERF2;IFI16;ZNF638;MEN1;IFI203;DDX58
helicase activity	CHD8;TDRD9;DHX33;HLTF;EIF4A1B;SNRNP200;NAV2;MCM3L;SMARCAD1
metal ion binding	CAR1;CYB5A;VPS29;MSRB1A;AOC1;PRIM2;LMAN2;ZEB2A;NEK10
protein binding	MYH11;LACE1;KIRREL2;SELS;ZNF622;MTAP1A;VAV2;MLPH;DPEP1
single-stranded DNA binding	HNRNPA1;HNRNPK;NABP2;ANXA1;OBFC2B;TREX1;MCM10;CSDA;RBMS1

DDX11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DDX11 here. Most of them are supplied by our site. Hope this information will be useful for your research of DDX11.

KAT7; PFN2

Immunoglobulin Superfamily CAMs