ddx11

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ddx11

Official Full Name DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11
Background DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms DDX11; DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 11 (S.cerevisiae CHL1 like helicase); probable ATP-dependent RNA helicase DDX11; CHL1; CHL1 like helicase
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDX11-11890H Recombinant Human DDX11, GST-tagged E.coli GST
    Human DDX11-28322TH Recombinant Human DDX11, GST-tagged Wheat Germ GST
    Human DDX11-454HCL Recombinant Human DDX11 cell lysate N/A
    Mouse DDX11-4399M Recombinant Mouse DDX11 Protein Mammalian Cell His
    Zebrafish DDX11-1711Z Recombinant Zebrafish DDX11 Mammalian Cell His

    ddx11 involved in several pathways and played different roles in them. We selected most pathways ddx11 participated on our site, such as IRE1alpha activates chaperones, Metabolism of proteins, Unfolded Protein Response (UPR), which may be useful for your reference. Also, other proteins which involved in the same pathway with ddx11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    IRE1alpha activates chaperones C19orf10; SERP1; CXXC1; TPP1; WIPI1; ASNA1; PREB; KLHDC3; FKBP14; SEC61B
    Metabolism of proteins ST6GAL2B; CNIH; EID3; GRPEL2; MUC1; TOMM40; TBCA; FBXW5; CKAP4; MTX1
    Unfolded Protein Response (UPR) SERP1; CTDSP2; DDX11; WIPI1; TPP1; KLHDC3; C19orf10; DNAJB9; ASNA1; YIF1A
    XBP1(S) activates chaperone genes SEC63; PDIA6; CXXC1; YIF1A; DDX11; KLHDC3; HYOU1; C19orf10; WIPI1; DNAJB9

    ddx11 has several biochemical functions, for example, 4 iron, 4 sulfur cluster binding, ATP binding, ATP-dependent DNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ddx11 itself. We selected most functions ddx11 had, and list some proteins which have the same functions with ddx11. You can find most of the proteins on our site.

    Function Related Protein
    4 iron, 4 sulfur cluster binding DPYDB; RTEL1; ERCC2; NUBP2; DPYD; ACO2; BRIP1; NTHL1; LIAS; REV3L
    ATP binding PFKMA; YARS; CDK17; EPHB3A; NETO2; ABCB6; PIK3CB; ABCG2A; CASK; CLCN4
    ATP-dependent DNA helicase activity RUVBL2; DDX3X; ERCC2; RECQL; ERCC3; FBXO18; WRN; XRCC6; XRCC5; CHD2
    DNA-dependent ATPase activity ERCC2; CHD8; SMARCA4; SMARCA2; CHD6; RAD51C; XRCC2; RAD51B; CDK7; RAD51L1
    RNA binding EXOSC3; KHDC3L; TERT; AGO1; ADAD2; DNMT1; ZFP385C; PES; HNRNPA1; EIF4G2A
    double-stranded DNA binding ZNF638; SMAD2; TP53; DMC1; SETMAR; HMGB3; NEIL3; AFF3; HMGB2; IFI203
    helicase activity TDRD9; MCM3L; PL10; EIF4A2; GTF2F2A; PIF1; DHX33; DDX19; MCM6L; BAT1
    metal ion binding ZNF543; ZNF592; IRF2BP2B; NFS1; SCD5; METAP2A; EME1; AGBL4; NT5C; LHX8
    protein binding TUBA3C; GORAB; PEX11G; LAMTOR1; CYB5R1; KPNA3; CHAMP1; ZBTB22; UFL1; FCRL4
    single-stranded DNA binding SSBP4; NEIL3; CNBPA; IGHMBP2; SUB1; TREX1; RAD51; FBXO18; NABP1A; CTC1

    ddx11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ddx11 here. Most of them are supplied by our site. Hope this information will be useful for your research of ddx11.

    KAT7; PFN2

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