ddx6 Protein, DEAD (Asp-Glu-Ala-Asp) box helicase 6


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Official Full Name DEAD (Asp-Glu-Ala-Asp) box helicase 6
Background The lymphoma-associated Rck/p54 gene product is a member of the DEAD box protein/RNA helicase family which has a variety of functions including translation initiation, pre-mRNA splicing, and ribosome assembly. Overexpression of human Rck in a guinea pig c
Synonyms DDX6; DEAD (Asp-Glu-Ala-Asp) box helicase 6; DEAD (Asp Glu Ala Asp) box polypeptide 6 , DEAD/H (Asp Glu Ala Asp/His) box polypeptide 6 (RNA helicase, 54kD) , HLR2; probable ATP-dependent RNA helicase DDX6; RCK; DEAD box-6; oncogene RCK; DEAD box protein
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DDX6-28328TH Recombinant Human DDX6 protein, GST-tagged Wheat Germ GST
    Human DDX6-45H Recombinant Human DDX6 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human DDX6-6998HCL Recombinant Human DDX6 293 Cell Lysate HEK293 N/A
    Mouse DDX6-4433M Recombinant Mouse DDX6 Protein Mammalian Cell His
    Chicken DDX6-1464C Recombinant Chicken DDX6 Mammalian Cell His
    Chicken DDX6-5430C Recombinant Chicken DDX6 Mammalian Cell His

    ddx6 involved in several pathways and played different roles in them. We selected most pathways ddx6 participated on our site, such as Deadenylation-dependent mRNA decay, Gene Expression, RNA degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ddx6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Deadenylation-dependent mRNA decay EIF4G1; EIF4A2; LSM6; EXOSC8; NT5C3B; D1BWG0212E; EIF4A1; EIF4B; DCP1B; C2orf29
    Gene Expression NSUN2; NRBF2B; BAZ2A; TBX5; ZNF563; NR1D2B; ZNF584; PHF1; ZNF75A; CLNS1A
    RNA degradation CNOT3B; PABPC1B; CNOT2; PFKM; EXOSC2; BTG2; WDR61; C1D; DCP2; PFKMB
    mRNA decay by 5 to 3 exoribonuclease DCP1B; LSM6; DDX6

    ddx6 has several biochemical functions, for example, ATP binding, ATP-dependent RNA helicase activity, RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ddx6 itself. We selected most functions ddx6 had, and list some proteins which have the same functions with ddx6. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PRKCB; ATP6V1A; DDX39A; DDX49; DDX3Y; GK; SMC5; VRK1; DYRK4; TSSK4
    ATP-dependent RNA helicase activity DDX10; DDX28; DDX21; DDX47; FAM120B; DDX31; SUPV3L1; ACTG2; EIF4A2; DDX25
    RNA helicase activity UAP1L1; FAM120B; DDX17; SKIV2L2; DHX16; CHST13; DHX15; RAD54B; DDX24; DDX6
    helicase activity DHX34; SHPRH; MCM6L; HLTF; SUPV3L1; DDX58; HELZ2; UPF1; ERCC6L; SMARCAL1
    poly(A) RNA binding Api5; VCP; TBL3; CNBP; HIST1H1E; MKI67IP; PES1; GNL3L; PPIB; ZFP326
    protein binding EPN3; NKX3-1; SMYD1; WDHD1; NDRG1; SH2D2A; SHISA5; CEP55; GBAS; FAIM
    protein domain specific binding MTOR; ARHGEF4; PHRF1; YWHAE1; TFDP2; SP100; NFASC; AKAP5; FAF1; EZR

    ddx6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ddx6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ddx6.

    DCP1A; EDC3; YBX1; TRIM37

    Johanneson, B; Chen, D; et al. Systematic validation of hypothesis-driven candidate genes for cervical cancer in a genome-wide association study. CARCINOGENESIS 35:2084-2088(2014).
    Kawahara, C; Yokota, S; et al. DDX6 localizes to nuage structures and the annulus of mammalian spermatogenic cells. HISTOCHEMISTRY AND CELL BIOLOGY 141:111-121(2014).

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