DHRS4

  • Official Full Name

    dehydrogenase/reductase (SDR family) member 4

  • Overview

    Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones.

  • Synonyms

    DHRS4;dehydrogenase/reductase (SDR family) member 4;dehydrogenase/reductase SDR family member 4;FLJ11008;humNRDR;SCAD SRL;SDR SRL;SDR25C2;short chain dehydrogenase/reductase family 25C;member 2;mouNRDR;NDRD;RRD;AI043103;AI790593;Carbonyl reductase;CR;D14Ucla2;DHRS4_HUMAN;NADPH dependent carbonyl reductase/NADP retinol dehydrogenase;NADPH dependent retinol dehydrogenase/reductase;NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase;NADPH-dependent retinol dehydrogenase/reductase;NRDR;Peroxisomal short chain alcohol dehydrogenase;Peroxisomal short-chain alcohol dehydrogenase;PHCR;PRO1800;PSCD;SCAD-SRL;SCADSRL;Short chain dehydrogenase/reductase family member 4;Short-chain dehydrogenase/reductase family member 4;UNQ851;NADP-dependent retinol dehydrogenase;dehydrogenase/reductase (SDR family) member 4 like 2A;short chain dehydrogenase/reductase family 25C, member 1;short chain dehydrogenase/reductase family 25C, member 2;SDR-SRL;SDR25C1

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Chicken
  • E.coli
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
DHRS4-11976H Recombinant Human DHRS4, GST-tagged E.coli Human GST 1-278a.a.
DHRS4-1258R Recombinant Rhesus monkey DHRS4 Protein, His-tagged Mammalian Cells Rhesus macaque His
DHRS4-1861R Recombinant Rat DHRS4 Protein Mammalian Cells Rat His
DHRS4-26686TH Recombinant Human DHRS4 Protein, His-tagged E.coli Human His 1-278aa
DHRS4-4730C Recombinant Chicken DHRS4 Mammalian Cells Chicken His
DHRS4-6936HCL Recombinant Human DHRS4 293 Cell Lysate HEK293 Human Non
DHRS4-1083R Recombinant Rhesus Macaque DHRS4 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
DHRS4-1083R-B Recombinant Rhesus Macaque DHRS4 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
DHRS4-1519R Recombinant Rat DHRS4 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
DHRS4-1519R-B Recombinant Rat DHRS4 Protein Pre-coupled Magnetic Beads HEK293 Rat
DHRS4-2539HF Recombinant Full Length Human DHRS4 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 278 amino acids

    Involved Pathway

    DHRS4 involved in several pathways and played different roles in them. We selected most pathways DHRS4 participated on our site, such as Metabolic pathways,Peroxisome,RA biosynthesis pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHRS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Peroxisome NUDT12,PHYH,FAR1,ACAA1,ACSL3A,CRATB,SOD1,NUDT7,PEX14,PRDX5
    the visual cycle I (vertebrates) RBP5,RBP3
    Signaling by Retinoic Acid CRABP1A,CRABP2A,PDK4,PDK3B,RARGA,RDH7,CRABP1B,CRABP2,RDH13,DHRS3A
    Signal Transduction RHOT2,OR56A1,RNF41,ANXA1C,RGR,WNT8-2,ARHGAP15,PPY,PMCH,TJP2B
    retinol biosynthesis RBP5,CES5A,DHRS9
    Retinol metabolism RDH10,SDR16C5B,CYP2B19,UGT2A1,AOX3L1,ALDH1A1,LRATA,ADH1,CYP2A4,UGT1A6
    RA biosynthesis pathway CYP26A1,ALDH8A1,RDH14B,DHRS3A,CRABP1,RDH14A,SDR16C5,AKR1C21,ADH8A,DHRS9
    Metabolic pathways PCYT1BA,GALNT9,COX6A1,GAD1B,DAO.2,NDUFAB1A,AGPAT9,HPDB,ST3GAL5,AGPS

    Protein Function

    DHRS4 has several biochemical functions, for example, 3-keto sterol reductase activity,alcohol dehydrogenase [NAD(P)+] activity,carbonyl reductase (NADPH) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHRS4 itself. We selected most functions DHRS4 had, and list some proteins which have the same functions with DHRS4. You can find most of the proteins on our site.

    Function Related Protein
    3-keto sterol reductase activity CBR3,HSD17B7
    oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor AKR1C3,AKR1C4,DCXR,CBR1,AKR1C2,AKR1C21,NDUFS7,AKR1C6
    receptor binding TNFSF12,NCK1,CSK,PLG,SCYL2,P2RX7,RIPK2,PVR,CRH,WNT5B
    carbonyl reductase (NADPH) activity CBR1,DHRS2,CBR3,CBR2

    Interacting Protein

    DHRS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHRS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHRS4.

    PEX14;PEX5

    Resources

    References

    Reviews

    Write a review

    Q&As

    Ask a question

    Ask a Question for All DHRS4 Products

    Required fields are marked with *

    My Review for All DHRS4 Products

    Required fields are marked with *