DHX9
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Official Full Name
DEAH (Asp-Glu-Ala-His) box polypeptide 9 -
Overview
This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13. -
Synonyms
DHX9;DEAH (Asp-Glu-Ala-His) box polypeptide 9;DDX9, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 9 (RNA helicase A, nuclear DNA helicase II;leukophysin) , LKP;ATP-dependent RNA helicase A;NDH II;RHA;leukophysin;DEAH box protein 9;nuclear DNA hel
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Zebrafish
- Mammalian Cells
- E.coli
- E.Coli/Yeast
- HEK293
- Wheat Germ
- Insect Cells
- His
- SUMO
- Flag
- Myc
- GST
- Avi
- Fc
Involved Pathway
DHX9 involved in several pathways and played different roles in them. We selected most pathways DHX9 participated on our site, such as Activated TLR4 signalling,Cytosolic sensors of pathogen-associated DNA,DEx/H-box helicases activate type I IFN and inflammatory cytokines production, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MyD88 cascade initiated on plasma membrane | TNIP2,PELI3,S100B,PELI2,DUSP3B,ALCAMB,TLR10,CHST13,PELI1,AGER |
| Activated TLR4 signalling | CHUK,AGER,CHST13,S100A12,TAB1,DUSP3B,MAP3K8,SIGIRR,PELI1,MAPKAPK2B |
| Immune System | ISG20,STIM1B,GBP5,MGC174155,WSB1,DDOST,IFI6,S100B,WWP1,KIF15 |
| Innate Immune System | MYO9B,CTSLL,MGC174857,AGER,MB21D1,TAX1BP1,POLR3F,S100B,DUSP3,DDX41 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | APPA,SAA1,APPB,S100B,S100A12,CHST13,AGER,ALCAMB |
| Gene Expression | FARS2,DNAJC8,ZNF317,TPRKB,NR1I2,COX8A,TET3,RARGA,ZNF486,SUZ12A |
| MyD88 dependent cascade initiated on endosome | S100B,CHST13,S100A12,ALCAMB |
| Cytosolic sensors of pathogen-associated DNA | POLR3F,NLRP4C,NLRP4B,APPA,POLR3C,AGER,LRRFIP1,RIPK3,TREX1,POLR3H |
Protein Function
DHX9 has several biochemical functions, for example, ATP binding,ATP-dependent DNA helicase activity,ATP-dependent RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX9 itself. We selected most functions DHX9 had, and list some proteins which have the same functions with DHX9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP-dependent RNA helicase activity | DDX46,EIF4A3,DDX39A,DDX55,YTHDC2,UPF1,DDX6,DDX3,DDX49,DDX19A |
| poly(A) RNA binding | EIF3A,GNB2L1,CKAP4,CPSF6,FIP1L1,EFTUD2,HSPA8,MSI1,TRAP1,RPS14 |
| protein binding | SF3A1,GAGE5,BAX,TMEM30A,TLR4,LDHD,FLOT2,ZNF394,BLVRA,HSP90AB1 |
| RNA helicase activity | CHST13,DHX15,DDX17,CTU1,FAM120B,DDX10,DDX6,DDX24,RAD54B,CCDC111 |
| DNA binding | HIST1H2AL,TBX1,HOXA10B,ZNF333,ZNF550,HOXB5B,ZBED1,ARNTL1B,DMTF1,GTF2IRD2 |
| ATP-dependent DNA helicase activity | RTEL1,FBXO18,ERCC3,XRCC6,WRN,CHD4,CHD1,BLM,G3BP1,DDX11 |
| RNA polymerase II transcription factor binding | TBX20,GATA3,GSK3B,GSC,SMAD4,MEF2A,GATA6,GATA5,TBX6,GATA1A |
| ATP binding | TYRO3,KLHL8,TRIP13,CDK3,OAS3,PANK2,NLRP9C,NADKD1,PRKCHA,PANK1B |
Interacting Protein
DHX9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX9 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX9.
NXF1;YBX1;cte_mpmv
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