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Official Full Name deoxyribonuclease II, lysosomal
Background This gene encodes a member of the DNase family. The protein, located in the lysosome, hydrolyzes DNA under acidic conditions and mediates the breakdown of DNA during erythropoiesis and apoptosis. Two codominant alleles have been characterized, DNASE2*L (low activity) and DNASE2*H (high activity), that differ at one nucleotide in the promoter region. The DNASE2*H allele is represented in this record.
Synonyms DNASE2; deoxyribonuclease II, lysosomal; DNL; DNL2; DNASE2A; Deoxyribonuclease-2-alpha; EC=; Acid DNase; Deoxyribonuclease II alpha; DNase II alpha; Lysosomal DNase II; R31240_2; deoxyribonuclease-2-alpha; R31240_2; acid DNase; DNase II alpha; lysosomal DNase II; DNase II, lysosomal; deoxyribonuclease II alpha; NP_001366.1; EC; Acid DNase
    • Species :
    • Cynomolgus Monkey
    • Human
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DNASE2-2778H Recombinant Human DNASE2 Protein, GST-tagged Wheat Germ GST
    Human DNASE2-449H Recombinant Human DNASE2 Protein, His-tagged E.coli His
    Human DNASE2-6863HCL Recombinant Human DNASE2 293 Cell Lysate HEK293 N/A
    Human DNASE2-698H Recombinant Human DNASE2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Cynomolgus Monkey DNASE2-470C Recombinant Cynomolgus DNASE2 Protein, His-tagged Mammalian Cell His
    Zebrafish DNASE2-6475Z Recombinant Zebrafish DNASE2 Mammalian Cell His

    dnase2 involved in several pathways and played different roles in them. We selected most pathways dnase2 participated on our site, such as Clathrin derived vesicle budding, Lysosome, Lysosome Vesicle Biogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with dnase2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Clathrin derived vesicle budding AP1S1; AP3S1; PPIAL4A; CLTB; HIP1RB; DNASE2; FTH1B; CNO; CLTC; TPD52L1
    Lysosome PPT2; TPP1; SCARB2; PLA2G15; CTSC; ASAH1; CTSG; GBA; Abca2; Ctsl
    Lysosome Vesicle Biogenesis CLVS2; CTSZ; DNASE2; AP4B1; AP1S3A; CLVS1; BLOC1S1
    Vesicle-mediated transport ARCN1B; RALAB; PPP6R3; PUM1; AP4B1; DTNBP1; CX27.5; CD163; MYO6B; AP1S3A
    trans-Golgi Network Vesicle Budding TCEAL4; TGOLN2; SNX9A; PICALMB; CPD; BLOC1S4; CLINT1; CNO; SH3D19; FTH1B

    dnase2 has several biochemical functions, for example, DNA binding, deoxyribonuclease II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by dnase2 itself. We selected most functions dnase2 had, and list some proteins which have the same functions with dnase2. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HELT; THAP3; SOX21B; UBN2A; FAM170A; KDM2B; TAF4B; ESR2; ZNF167; FOXG1A
    deoxyribonuclease II activity DNASE2; DNASE2B; DNASE2A

    dnase2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dnase2 here. Most of them are supplied by our site. Hope this information will be useful for your research of dnase2.

    RUVBL2; RUVBL1; cona_canen

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