DNASE2B
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Official Full Name
deoxyribonuclease II beta
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Overview
The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. -
Synonyms
DNASE2B; deoxyribonuclease II beta; deoxyribonuclease-2-beta; DLAD; Deoxyribonuclease 2 beta; Deoxyribonuclease 2 beta precursor; DNase 2 like acid DNase; DNASE 2B; DNase II beta; DNase II like acid DNase; DNASE2; DNase2 like acid DNase; DnaseIIb; EC 3.1.22.1; Endonuclease DLAD; Lysosomal DNase II; UOX; DNase2-like acid DNase; DNase II-like acid DNase;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
DNASE2B involved in several pathways and played different roles in them. We selected most pathways DNASE2B participated on our site, such as Lysosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNASE2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | NAGA;ATP6AP1B;ARSG;CLN5;AP3M2;ATP6V0B;MFSD8;LAPTM4B;ENTPD4 |
DNASE2B has several biochemical functions, for example, deoxyribonuclease II activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNASE2B itself. We selected most functions DNASE2B had, and list some proteins which have the same functions with DNASE2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| deoxyribonuclease II activity | DNASE2;DNASE2A;DNASE2B |
DNASE2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNASE2B here. Most of them are supplied by our site. Hope this information will be useful for your research of DNASE2B.
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